The analysis of yield data of eighteen accessions of "egusi" melon across four environments was determined. Genotype main effects and genotype x environment interaction (GGE biplot) method has been described as a very efficient tool for the analyses of multi-environment yield trial of crop varieties, especially where there exists a genotype x environment interaction. Thus, eighteen accessions of "egusi" melon (Citrullus lanatus) were evaluated in four environments in Southwest Nigeria. Strong genotype x environment interaction was confirmed. Among the accessions, DL99/75, DL 99/76 and DD98/506 performed best in Abeokuta 2 environment while L1, DD98/4, DD98/3, 131DA and L4 performed best in Abeokuta 1, Ilaro 1 and Ilaro 2. Accession DD98/550, DD98/7, DD98/533, DD98/511, DD95/549, L3, DL99/71, V2, L2 and L6 did not perform well in all the environments. GGE biplot also ranked the accessions in their order of greater value. Accession DL99/75 was ranked first followed by DD98/506 and the least performed accession was DD98/511.