2005
DOI: 10.1016/j.bbr.2005.02.010
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Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance

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Cited by 45 publications
(35 citation statements)
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“…Both subunits are closely linked with cognition and performances in spatial memory tasks [20,21,22,23], a form of cognition specifically altered in human and AD mouse models [24,25]. In line with our results, age-related cognitive deficits in the hippocampus-dependent Morris Water Maze spatial task are reduced in Pdyn KO mice [26]. Future studies will be necessary to determine the exact mechanism of the interactions of dynorphins with the glutamatergic system and to evaluate whether expression of these peptides correlated with memory impairments in AD mouse models and patients suffering from the disease.…”
Section: Discussionsupporting
confidence: 79%
“…Both subunits are closely linked with cognition and performances in spatial memory tasks [20,21,22,23], a form of cognition specifically altered in human and AD mouse models [24,25]. In line with our results, age-related cognitive deficits in the hippocampus-dependent Morris Water Maze spatial task are reduced in Pdyn KO mice [26]. Future studies will be necessary to determine the exact mechanism of the interactions of dynorphins with the glutamatergic system and to evaluate whether expression of these peptides correlated with memory impairments in AD mouse models and patients suffering from the disease.…”
Section: Discussionsupporting
confidence: 79%
“…These effects appear to be relevant for processing of information associated with learning and memory. Behavioral data obtained with synthetic dynorphins and with prodynorphin deficient mice support this notion (Kameyama et al, 1994;Ukai et al, 1996;Hiramatsu et al, 1998Wall and Messier, 2000;Nguyen et al, 2005).…”
Section: Introductionmentioning
confidence: 67%
“…Consistently, prodynorphin knockout mice demonstrated diminished age-associated impairment in spatial water maze performance suggesting adverse actions of endogenous dynorphins. Endogenous dynorphins are upregulated with age and, consistently, less impairment was observed in aged prodynorphin-deficient mice (Nguyen et al, 2005).…”
Section: Discussionmentioning
confidence: 88%
“…For example, chronic exposure to MOR agonists negatively impacts hippocampal function, defined here as hippocampal-dependent behaviors, while blockade of MOR and other opiate receptors enhances hippocampal function Newsom, 1989, Spain andNewsom, 1991). Supporting the role for MOR in hippocampal function, transgenic mice that lack MOR or endogenous MOR ligands have altered behavior in hippocampal-dependent tasks (Jamot et al, 2003, Jang et al, 2003, Nguyen et al, 2005, Sanders et al, 2005. These studies encourage more detailed exploration of how MOR regulates hippocampal structure and function.…”
Section: Introductionmentioning
confidence: 94%