Proerectile effects of apomorphine in mice

Rampin, Olivier; Jerome, Nathalie; Suaudeau, Charles

doi:10.1016/s0024-3205(03)00122-x

Cited by 42 publications

(24 citation statements)

References 22 publications

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“…The size and direction of the acute behavioral changes are in agreement with previous reports, as observed in rats (Bitran and Hull, 1987;Hsieh et al, 2004;Hull et al, 1986;Paglietti et al, 1978;Tagliamonte et al, 1974), mice (Rampin et al, 2003) and men (Hagemann et al, 2003;Montorsi et al, 2003). Melis and Argiolas (1995), reviewing the available data, described the changes observed as an indication , deep and superficial layers of the prelimbic cortex (C and D) and the nucleus accumbens core and shell (E and F) of male rats that remained in the home-cage ("non-sex") or underwent a 30-min sexual behavior test with a receptive female ("sex").…”

Section: Behavioral Effects Of Apomorphinesupporting

confidence: 92%

“…Apomorphine is a mixed dopamine receptor agonist (D 2 N D 1 N D 4 ), inducing changes in male sexual behavior in the rat (Bitran and Hull, 1987;Giuliano et al, 2002;Hsieh et al, 2004;Hull et al, 1986;Malmnas, 1973;Paglietti et al, 1978;Pehek et al, 1989;Tagliamonte et al, 1974) and mice (Rampin et al, 2003). In reviewing the available data, Melis and Argiolas (1995), described the changes observed as indicative for a lowered ejaculatory threshold.…”

Section: Introductionmentioning

confidence: 99%

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Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Olivier

Jong

Dederen

et al. 2007

European Journal of Pharmacology

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Apomorphine is a non-selective dopaminergic receptor agonist. Because of its pro-erectile effects, apomorphine is clinically used for treatment of erectile dysfunction. We investigated the effects of subcutaneous apomorphine administration (0.4 mg/kg rat) on sexual behavior and matinginduced Fos-expression following acute (day 1) or chronic apomorphine treatment (days 8 and 15) in sexually experienced male rats. Consistent facilitatory effects of apomorphine were observed in the reduced numbers of mounts and intromissions over time and an increased ejaculation frequency on day 1. The first post-ejaculatory interval, however, was lengthened, while other behavioral parameters were unaffected. Fosimmunoreactivity induced by acute apomorphine administration (barrel cortex, paraventricular hypothalamic nucleus, central amygdala and locus coeruleus) was strongly reduced after chronic administration. After mating, induction of Fos-immunoreactivity was observed in well-known areas like medial preoptic nucleus and the posterodorsal medial amygdaloid area. Apomorphine, however, reduced mating-induced Fosimmunoreactivity in the nucleus accumbens shell and prevented its occurrence in its core area. This remarkable apomorphine effect was not observed in any other brain area. We conclude that the behavioral (pro-erectile) effects of apomorphine are consistent over time, and that the diminished accumbens-Fos-immunoreactivity and the elongated post-ejaculatory interval may reflect a decreased response to remote cues from the estrus female.

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Section: Behavioral Effects Of Apomorphinesupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Olivier

Jong

Dederen

et al. 2007

European Journal of Pharmacology

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“…Administration of several DA antagonists (clozapine, haloperidol, pimozide, or SCH 23390) also inhibited anticipatory sexual behavior, as sexually experienced male rats receiving drugs displayed fewer anticipatory level changes, before the introduction of a sexually receptive female [19], in a bilevel chamber that is used as an assay of sexual motivation [20]. Finally, it appears that central, not peripheral, DA receptors facilitate erectile function, because erections and erection-like responses elicited by systemically administered apomorphine were blocked by haloperidol (a centrally active DA antagonist) but not domperidone (a peripherally active DA antagonist) in mice [21] and rats [22]. Together, these and other pharmacological experiments indicate that increased DA activity enhances male sexual behavior.…”

Section: Dopamine Antagonistsmentioning

confidence: 99%

Dopamine, the medial preoptic area, and male sexual behavior

Domínguez

Hull

2005

Physiology & Behavior

248

190

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“…The latency to the first grooming erection, and the time spent in erection after each mount with intromission were measured in experiment 2. Erection was scored when the male stood on its hindlimbs, bent its body forward, head down to reach the penis, and performed genital grooming while displaying hip movements, as previously described (Rampin et al, 2003;Rampin et al, 2006).…”

Section: Male-typical Behaviorsmentioning

confidence: 99%

Conditional Inactivation of Androgen Receptor Gene in the Nervous System: Effects on Male Behavioral and Neuroendocrine Responses

Raskin¹,

Gendt²,

Duittoz³

et al. 2009

J. Neurosci.

192

221

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Testosterone (T) profoundly influences central sexual differentiation and functions. In the brain, T signals either directly through androgen receptor (AR) or indirectly through estrogen receptor (ER) following aromatization into E2 (17-␤-estradiol).As T, through AR, also controls peripheral male sexual differentiation, the relative contribution of central AR in T-mediated regulation of behavioral and neuroendocrine responses still remains unclear. To address this question, we generated, by using Cre-loxP technology, mice selectively lacking AR expression in the nervous system. The mutant male urogenital tract was normally developed, and mice were able to produce offspring. Nonetheless, sexual motivation and performance as well as aggressive behaviors were affected. Only a low percentage of males displayed a complete sexual behavior and offensive attacks. The latency to show masculine behaviors was increased and copulation length prolonged. Erectile activity during mating was also altered. These alterations occurred despite increased levels of T and its metabolites, and an unaffected number of ER␣-immunoreactive cells. Olfactory preference and neuronal activation, mapped by Fos immunoreactivity, following exposure to estrus female-soiled bedding were also normal. At comparable T levels, greater differences in masculine behaviors were observed between gonadectomized control and mutant males. AR invalidation in the nervous system also disrupted the somatotropic axis since mutant males exhibited growth retardation and decreased serum levels of insulin-like growth factor I. Our findings show that central AR is required in T-induced regulation of male-typical behaviors and gonadotrope and somatotropic axes. This genetic model offers a unique opportunity in the understanding of AR's role in cerebral functions of T.

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Proerectile effects of apomorphine in mice

Cited by 42 publications

References 22 publications

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Dopamine, the medial preoptic area, and male sexual behavior

Conditional Inactivation of Androgen Receptor Gene in the Nervous System: Effects on Male Behavioral and Neuroendocrine Responses

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