This Design-Based Research (DBR) study was conducted over a two-year period, and investigated the transformative learning of six high school computer science teachers through the application of professional development (PD) training with a focus on Culturally Responsive Computing (CRC). Findings reveal ways in which teachers’ understanding and enactment of CRC in their classrooms led to increased student engagement, knowledge of diverse learning needs, and improved access to cultural resources to specifically meet girls’ needs. The authors discovered positive effects on the teachers’ strategies in the classroom, especially in terms of understanding how historically marginalized students benefit from instruction that considers their cultural practices and gender identities.