Nurse practitioners (NPs), as key healthcare professional, play a critical role in the provision and coordination of care, prevention of adverse events, health service throughput, and patient outcomes. Patient experience is considered as one of the pillars of quality in healthcare, along with patient safety and clinical outcomes. Based on the aforementioned, nurse practitioners have a vital role in providing clinical nursing care to patients within or outside of the immediate medical imaging (MI) working environment. Their evolving role expansion in medical imaging is documented in the literature. The purpose of this chapter is to create further awareness of the nurse practitioner in medical imaging.