This study aimed to determine the factors associated with nursing professionalism among Korean nursing students. This cross‐sectional study was carried out using a convenient sample comprising 247 students enrolled in a four‐year Bachelor of Science Nursing program from September 6–27, 2021. A self‐reported structured questionnaire was employed to explore the relationships among ego‐resilience, self‐leadership, clinical learning environment, academic satisfaction, clinical competency, and nursing professionalism by utilizing structural equation modeling. The modified model exhibited good fit indices. Learning‐related factors, including clinical learning environments, academic satisfaction, and clinical competency, directly affected nursing professionalism. Self‐leadership and the clinical learning environment were indirectly associated with nursing professionalism via both academic satisfaction and clinical competency. Regarding ego‐resilience, it only indirectly affected nursing professionalism via academic satisfaction. Creating a student‐centered learning environment may be vital to improve students' major and clinical performance, thereby boosting nursing professionalism. Furthermore, nurse educators should consider individual psychological aspects of students when designing the nursing curriculum to foster nursing professionalism. Longitudinal studies are needed to determine if our model is available to explain the development of professionalism among nursing students.