Concerns regarding compassion fatigue and burn-out in veterinary practice are steadily increasing. Burn-out is defined as the state in which a person feels emotionally, physically and mentally exhausted. Work-related stress can have a significant impact on our quality of life and unfortunately lead to burn-out, moral distress and compassion fatigue. As veterinary professionals are exposed to ethical dilemmas and stressful situations daily, it is important that they are aware of the signs of burn-out and how it can be managed.