Profil des utilisateurs d’anti-inflammatoires non stéroïdiens

Lugardon, Stéphanie; Roussel, Henri; Bourrel, Robert; Sciortino, V.; Montastruc, Jean‐Louis; Lapeyre‐Mestre, Maryse

doi:10.2515/therapie:2006029

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…The characteristics of NSAID prescriptions are close to the ones found in a monthly prevalence descriptive study leaded in the same area in 2006 [9]. First prescriptions of NSAIDs among hypertensive patients do not differ from NSAIDs prescriptions in general population, as the more frequently prescribed NSAIDs are in both studies ibuprofen, ketoprofen, diclofenac and piroxicam.…”

Section: Discussionsupporting

confidence: 73%

Laboratory Monitoring of Patients Treated with Antihypertensive Drugs and Newly Exposed to Non Steroidal Anti-Inflammatory Drugs: A Cohort Study

et al. 2012

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Background Drug-Drug Interactions between Non Steroidal Anti-Inflammatory Drugs (NSAIDs) and Angiotensin Converting Enzyme Inhibitors (ACEIs), Angiotensin Receptor Blocker (ARBs) or diuretics can lead to renal failure and hyperkalemia. Thus, monitoring of serum creatinine and potassium is recommended when a first dispensing of NSAID occur in patients treated with these drugs. Methods We conducted a pharmacoepidemiological retrospective cohort study using data from the French Health Insurance Reimbursement Database to evaluate the proportion of serum creatinine and potassium laboratory monitoring in patients treated with ACEI, ARB or diuretic and receiving a first dispensing of NSAID. We described the first dispensing of NSAID among 3,500 patients of a 4-year cohort (6,633 patients treated with antihypertensive drugs) and analyzed serum creatinine and potassium laboratory monitoring within the 3 weeks after the first NSAID dispensing. Results General Practitioners were the most frequent prescribers of NSAIDs (85.5%, 95% CI: 84.3–86.6). The more commonly prescribed NSAIDs were ibuprofen (20%), ketoprofen (15%), diclofenac (15%) and piroxicam (12%). Serum creatinine and potassium monitoring was 10.7% (95% CI: 9.5–11.8) in patients treated by ACEIs, ARBs or diuretics. Overall, monitoring was more frequently performed to women aged over 60, treated with digoxin or glucose lowering drugs, but not to patients treated with ACEIs, ARBs or diuretics. Monitoring was more frequent when NSAIDs' prescribers were cardiologists or anesthesiologists. Conclusion Monitoring of serum creatinine and potassium of patients treated with ACEIs, ARBs or diuretics and receiving a first NSAID dispensing is insufficiently performed and needs to be reinforced through specific interventions.

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Section: Discussionsupporting

confidence: 73%

Laboratory Monitoring of Patients Treated with Antihypertensive Drugs and Newly Exposed to Non Steroidal Anti-Inflammatory Drugs: A Cohort Study

et al. 2012

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“…In addition, over half of the prospective studies relied on self-reported data on NSAID use, prone to exposure misclassification, while studies exploring the associations between NSAID use and breast cancer risk using medico-administrative healthcare databases [ 8 – 17 ] had very limited data on potential confounding factors and were not able to evaluate whether the associations differed by specific breast cancer subtypes. Furthermore, there is a lack of epidemiological studies considering the use of other drugs as potential confounders/effect modifiers even though NSAIDs are frequently used concomitantly with other drugs such as proton pump inhibitors (PPIs) [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women

et al. 2020

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Background Although anti-inflammatory agents could theoretically have anticancer properties, results from cohort studies on nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer (BC) risk are inconsistent. Methods We investigated the association between NSAID use and BC incidence in the French E3N prospective cohort, which includes 98,995 women born between 1925 and 1950 and insured by a health insurance plan that covers mostly teachers. Self-reported information on lifestyle and medical history has been collected biennially by questionnaires and matched with data from a drug reimbursement database covering the period 2004–2014. Women who self-reported current NSAID use in the 2000 or 2002 questionnaires or with at least two reimbursements in any previous 3-month period were defined as exposed to NSAIDs. Multivariable Cox regression models were used to estimate hazard ratios (HRs) for the association of NSAID use with BC risk. Results In the current analysis, 62,512 postmenopausal women were followed between 2004 and 2014 (9 years on average, starting at a mean age of 63 years; 2864 incident BC). In multivariable models, there was no statistically significant association between NSAID use and BC risk [HR = 1.00 (0.92–1.08), compared with non-exposed women]. The NSAID-BC associations did not differ by NSAID types, BC subtypes, risk factors, and comorbidities, nor by duration and dose of use. However, a statistically significant interaction was observed by proton pump inhibitor (PPI) drug use (Pinteraction = 0.01) whereby a decreased risk of BC with NSAID use was only observed among women who also used PPI before. Conclusion Only women who used NSAIDs after having used PPI had a lower risk of BC. This result is novel and requires replication in other studies.

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Pharmacoepidemiological research using French reimbursement databases: yes we can!

Martin-Latry

Bégaud

2010

Pharmacoepidemiology and Drug

125

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Profil des utilisateurs d’anti-inflammatoires non stéroïdiens

Cited by 8 publications

References 9 publications

Laboratory Monitoring of Patients Treated with Antihypertensive Drugs and Newly Exposed to Non Steroidal Anti-Inflammatory Drugs: A Cohort Study

Laboratory Monitoring of Patients Treated with Antihypertensive Drugs and Newly Exposed to Non Steroidal Anti-Inflammatory Drugs: A Cohort Study

Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women

Pharmacoepidemiological research using French reimbursement databases: yes we can!

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