Profil épidémiologique, moléculaire et pronostic du cancer du sein au sud de la République du Bénin

Gnangnon, Freddy Houéhanou Rodrigue; Takin, Romulus; Gbéssi, Dansou Gaspard; Ahomadegbé, C.; Amidou, Salimanou Ariyoh; Denakpo, Justin Lewis; Méhinto, Delphin Kuassi; Houinato, Dismand

doi:10.1016/j.respe.2020.03.077

Cited by 4 publications

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“…In our study, only a few cases (7.33%) had a family history of breast cancer. Our result is slightly higher than that of Mihret et al in Ethiopia recently in 2021 which had found a proportion of 5.2% of family history of breast cancer [34] and significantly lower than that reported in Benin by Gnangnon et al 2020 with a frequency of 11.8% [35] . This proportion of 7.33% of cases of family history discovered in this study will certainly constitute the future fields of research to be treated in the future; otherwise, there is currently no evidence to link the etiology of this family history to our breast cancer cases.…”

Section: Discussioncontrasting

confidence: 85%

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Malanda

Boumba

Malonga

2021

Int J Health Sci Res

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Introduction: Breast cancer is a heterogeneous disease with a variety of morphological, molecular, treatment response and clinical outcome characteristics. The objective of this work was to assess the epidemiological, histological, immunohistochemical and molecular subtypes of breast cancer in women in the Republic of Congo. Material and Methods: We carried out a cross-sectional descriptive study which took place from January 1, 2014 to December 31, 2020. The study focused on 150 cases of breast cancer in patients diagnosed at the University Hospital of Brazzaville (CHU-B). The epidemiological, clinical, histological, immunohistochemical and molecular subtypes were the variables studied. Results: The mean age was 48.09 ± 13.87 years with the extremes of 22 years and 80 years. The study of the profession; the most represented in our study was that of the cultivator 20.67%. A predominance of breast cancer localization was observed in the left breast in 47.33%. The frequency of a family history was 7.33% or 11 cases. The most frequently represented histologic type was 62% invasive non-specific type carcinoma (CITNS). The most represented histological grade was Scarff Bloom Richardson grade II (51.33%), followed by grade III 24% and grade I in 12% of cases. Regarding the results of IHC; of the 150 cases, 102 (68%) had positive hormone receptors (HR +). The ORs were positive in 102 cases (68%) while the PRs were positive in 98 cases (65.33%). The Her2 oncogene was over expressed in 38 cases (25.3%). The Ki-67 proliferation index was known for the 150 cases, including 77 (51.33%) less than 15% and 73 (48.67%) greater than or equal to 15%. The distribution of molecular subtypes was 46% luminal A, 22% triple negative, 17% luminal B and 10% Her2 +. Tumors of unknown molecular profile were 5%. The correlation was found between molecular subtype and histological type. This result was statistically significant (p <0.05). For the rest. There was no correlation between age and SBR grade (p> 0.05). The correlation was found between molecular subtype and histological type. This result was statistically significant (p <0.05). For the rest. There was no correlation between age and SBR grade (p> 0.05). The correlation was found between molecular subtype and histological type. This result was statistically significant (p <0.05). For the rest. There was no correlation between age and SBR grade (p> 0.05). Conclusion: It should be noted that the association between histological and immunohistochemical diagnosis can help determine the phenotype of breast cancer, with the aim of guiding treatment and therefore improving response to treatment. Key words: Epidemiology, Histology, Immunohistochemistry, molecular subtypes, breast cancer, Republic of Congo.

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Section: Discussioncontrasting

confidence: 85%

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Malanda

Boumba

Malonga

2021

Int J Health Sci Res

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“…In our study, the 5-year overall survival rate was 47%. Similar rates were reported by Gnangnon et al [53] in southern Benin, Zingué et al [54] in Cameroon, and Galukande et al [55] [51]. Our survival rate is however much lower than those found in developed countries.…”

Section: Breast Cancer Survival and Prognosis Analysissupporting

confidence: 89%

Epidemiology, Diagnosis and Survival of Breast Cancer: Data from the Population-Based Cancer Registry of the City of Parakou from 2017 to 2021

Brun¹,

Imorou²,

Togbenon³

et al. 2023

OJPathology

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Background: Breast cancer mortality remains high in the majority of developing countries. The Ministry of Health has established two population-based cancer registries in Benin: the first one in Cotonou in 2014 and the second one in Parakou in 2017. However, there is a scarcity of data on breast cancer survival and prognosis in Benin Republic. Objective: This study sought to investigate epidemiological, diagnostic, and survival aspects of breast cancer in Parakou, based on data from its population-based cancer registry from 2017 to 2021. Method: For descriptive and analytical purposes, we used a retrospective cohort design. From January 24, 2022 to August 31, 2022, data were collected in all health facilities covered by the Parakou population-based cancer registry using an individual questionnaire. Survival and prognosis analysis were performed using KAPLAN MEIER method and David COX proportional hazard model respectively. Result: A total of 81 patients have been included in this study. The incidence rate of breast cancer in Parakou was 17.5 per 100,000 person-years with a mortality rate of 2.76 per 100,000 person-years. The median age at diagnosis was 44.

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“…Le carcinome infiltrant de type non spécifique représente le type histologique des cancers du sein retrouvé dans la littérature [9,11,12]. L'immunohistochimie constitue une base pronostique et thérapeutique dans la prise en charge des cancers mammaires.…”

Section: Données Cliniquesunclassified

“…Son inaccessibilité géographique et financière justifie le taux faible de réalisation dans notre contexte [3,11]. Le cancer mammaire triple négatif prédominerait chez le sujet africain [11,12]. Ce sous-type est associé à une forte probabilité de mutation du gène BRCA, et à un mauvais pronostic [11].…”

Section: Données Cliniquesunclassified

Breast Cancer in Bobo-Dioulasso, Burkina Faso: Management OutcomesLe Cancer du Sein �Bobo-Dioulasso, Burkina Faso : R閟ultats de la Prise en Charge

Konkobo¹,

Dieudonn�Hien²,

B閘emlilga³

et al. 2022

Oncologie

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Introduction : La prise en charge du cancer du sein en Afrique subsaharienne est confrontée à des difficultés diagnostiques et thérapeutiques. Objectif : Décrire le profil clinique, thérapeutique et évolutif du cancer du sein au Burkina Faso. Patients et méthodes : Il s'agit d'une étude de cohorte rétrospective du 1er Juillet 2015 au 31 Décembre 2021 au CHU Sourô Sanou à Bobo Dioulasso, 2ème ville du Burkina Faso. Elle a porté sur les données cliniques, thérapeutiques et évolutives des cancers du sein, confirmés à l'histologie. Résultats : Nous avons colligé 368 cas de cancer du sein dont 8 cas chez l'homme (2%). L'âge moyen des patients était de 46,6 ± 12,1 ans [15-90]. Le délai moyen de consultation était de 23,9 ± 15,9 mois [2-60 mois]. Les tumeurs T4 étaient observées dans 77% (n = 283). Le carcinome infiltrant de type non spécifique prédominait (94,6%). Après le bilan d'extension, sur 326 patients les stades III et IV présentaient une fréquence de 45,7% (n = 149) et 41% (n = 134). Les données de l'examen immuno-histochimique notaient le sous-type triple négatif chez 18 patients sur 34 réalisations. La prévalence du VIH parmi les cas de cancer du sein était élevée (3%). La chirurgie a été réalisée chez 203 patients (55%). Il s'agissait d'une chirurgie curative chez 138 patients (37,5%). Parmi eux, 116 avaient reçu une chimiothérapie néo-adjuvante. La chirurgie a été radicale type mastectomie selon Madden dans 34,2% (n = 126/368), et conservatrice dans 3,3% des cas (12/368). La mastectomie de propreté a été faite chez 65 patients (17,7%). La radiothérapie a été réalisée dans 4,9% (n = 18) des cas. La survie globale à 3 ans et à 5 ans était de 50% et 22% respectivement. Les stades avancés étaient associés à une survie faible (p = 0,0001). Conclusion : Le cancer du sein est fréquent. L'âge jeune, le stade avancé et le sous-type triple négatif caractérisent le cancer du sein dans notre contexte. La survie est corrélée au stade et reste faible. Mots clésBurkina Faso ; cancer du sein ; stade ; survie ; traitement

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Profil épidémiologique, moléculaire et pronostic du cancer du sein au sud de la République du Bénin

Cited by 4 publications

References 0 publications

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Epidemiology, Diagnosis and Survival of Breast Cancer: Data from the Population-Based Cancer Registry of the City of Parakou from 2017 to 2021

Breast Cancer in Bobo-Dioulasso, Burkina Faso: Management OutcomesLe Cancer du Sein �Bobo-Dioulasso, Burkina Faso : R閟ultats de la Prise en Charge

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