Profil spermiologique des hommes infertiles au Mali

Traoré, Mahamadou; Touré, Amadou; Sissoko, Sibiri; Samake, N’Dia Fatoumata

doi:10.1007/bf03040718

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…In Mali, 57.2% of the study population had only one wife, the others were polygamous. This finding sustains the hypothesis men would seek the solution of their infertility in the marriage of a new wife, sometimes supported by their family [30].…”

Section: Discussionsupporting

confidence: 79%

Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting

Ngalle¹,

Donfack²,

Mpah³

et al. 2020

IJCU

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Background: Male infertility is defined as a lack of pregnancy for a couple after 12 months of regular and normal sexual intercourse without contraception with the cause being clearly from the male origin. Contrary to popular belief, the prevalence of male infertility is similar to that of female infertility and sometimes even higher. However, data on the subject in Cameron are scarce and nonexistent in the city of Douala. This motivated the realization of this study in two centers in the city of Douala. The objective was to describe the epidemiological profile of male infertility. Methods: We conducted a crosssectional study among patients who consulted for infertility in two hospital centers in Douala from January 2014 to October 2019. A consecutive sample of all eligible cases was considered for this study. Data were analyzed using Statistical Package for Social Sciences (SPSS Inc, Chicago, Illinois, USA) V. 20.0 and EPI-INFO V. 3.5 software. Analyzed variables included sociodemographic data (age, marital status, educational level, profession, region, alcohol, smoking habit and mean infertility duration) and other causes of infertility (obesity, history of testes infection, STI, testes traumatism, varicocele or varicocele surgery, herniorrhaphy, genetic or malformative disease). Results: We included 137 patients' records. The frequency of male infertility for patients consulting in urology was 5.6%. Their average age was 35.4±7.4 years. The average number of sexual intercourses per week was 2.7±0.97. Those patients were mainly from an intellectual profession (40.2%), married (71.5%) with a higher education level (67.2%). Almost 60% of the studied population had alcohol consumption. Primary infertility accounted for 65.7% of the study population and the average duration of infertility was 5.9±5.3 years. The main factors for infertility were respectively history of sexually transmitted infections (STI) in 59 (43.1%) and childhood mumps in 42 (32.7%) cases. Furthermore, herniorrhaphy (16.1%) and varicocelectomy (10.9%) were the most representative surgical background. Conclusion: Male infertility is not uncommon in urological consultation with primary infertility been more frequent. Risk factors of infertility in our setting included a history of STI, mumps, and surgery.

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Section: Discussionsupporting

confidence: 79%

Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting

Ngalle¹,

Donfack²,

Mpah³

et al. 2020

IJCU

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“…This proportion is lower compared to the findings of Mahamadou Traoré et al in Mali (44%). 27 The difference is explained by the normal minimum value of the volume of sperm considered, this was 2ml in the study conducted in Mali and 1.5 ml in ours.…”

Section: Discussioncontrasting

confidence: 50%

Is thyroid stimulating hormone titration mandatory in the routine work-up of African males from infertile couples?

Ngowa

Tchawe

Voundi

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: The impact of thyroid hormones on male reproductive function is still insufficiently understood. The objectives of this study were to determine the frequency of thyroid dysfunction in men from infertile couples and to establish an association between TSH (thyroid stimulating hormone) values and sperm parameters.Methods: We conducted a cross-sectional analytical study on a consecutive series of men managed for couple infertility in two reference hospitals of Yaoundé from November 2017 to May 2018. For each participant, a questionnaire was administered, TSH was assayed using electro-chemo-luminescence and sperm analyzed. Statistical methods used were the Mann-Whitney test and the Spearman correlation coefficient with a significance threshold of 5%.Results: Overall, 123 men were recruited. The median age was 44 years old [38-50 years]; 60 (48.79%) patients had couple infertility lasting between 1 and 5 years. Primary infertility of the couple was the most common (82 cases, 66.70%). After sperm analysis, 86 patients (70%) had one or more anomalies. TSH titration revealed 03 (2.44%) cases of subclinical hyperthyroidism, 05 (4.06%) subclinical hypothyroidism and 115 (93.50%) euthyroidism. Significant associations were found between TSH and sperm parameters in the group of patients with thyroid dysfunction, but none in the euthyroid group.Conclusions: Frequency of dysthyroidism is low among African males from infertile couples. We noted significant correlations between TSH values and sperm parameters. The low frequency of thyroid dysfunction would be against a TSH titration in the routine work-up of these patients.

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“…Couple infertility is a global phenomenon that affects approximately 15% of the adult population. Male infertility is a new problem in Africa because in the past, sterility was said to concern only women [1] . However, within the couple, the male’s responsibility in the inability to procreate is also as important as that of women because the incidence of this is approximately 50% [2] .…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of mitochondrial DNA genes involved in asthenozoospermia in infertile patients of Côte d’Ivoire

Ayekoue

N’zi

Ako

et al. 2023

Reproductive and Developmental Medicine

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Objective: The relationship between mitochondrial DNA (mtDNA) polymorphisms and abnormalities in sperm quality has been the subject of several studies, with the objective of improving the treatment of male infertility. This study, which contributes to the identification of genetic markers of sperm abnormalities, was conducted to study mtDNA mutations in the asthenozoospermia profile. Methods: This case-control study included 30 patients with asthenozoospermia and 28 with normospermia after spermogram and spermocytogram analyses. After the extraction of total DNA from the spermatozoa of 58 ejaculates from these individuals using the phenol-chloroform method, the amplification of genes of interest in mtDNA using specific primers was performed by conventional polymerase chain reaction, and sequencing was used to detect mutations. Results: Male patients with asthenozoospermia in the tertiary sector had significantly more mutant- than wild-type (P = 0.0005) MT-CO II genes. Similarly, for the same gene, males with asthenozoospermia and primary infertility had significantly more mutants than the wild-type (P = 0.001). Sequencing revealed 29 mutations that were observed only with asthenozoospermia, which could be the basis for low sperm mobility. Conclusion: This study identified several mutations in mtDNA genes that could be considered genetic markers of asthenozoospermia if confirmed in a deeper study.

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Profil spermiologique des hommes infertiles au Mali

Cited by 4 publications

References 6 publications

Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting

Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting

Is thyroid stimulating hormone titration mandatory in the routine work-up of African males from infertile couples?

Polymorphism of mitochondrial DNA genes involved in asthenozoospermia in infertile patients of Côte d’Ivoire

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