Profile and Potential Significance of Dendritic Cells in Head and Neck Squamous Cell Carcinoma

Abstract

Background/Aim: The aim of the study was the analysis of immunohistochemical expression of S100 protein and CD1a by dendritic cells (DCs) from head and neck squamous cell carcinoma (HNSCC), correlation with the histological grade, as well as analysis of the potential significance of antigen-presenting cells according to tumor location. Patients and Methods: Samples were collected from 50 patients with HNSCC, conventionally stained with hematoxylin and eosin for pathological diagnosis and grade, followed by immunohistochemical evaluation with S100 protein and CD1a expression. Results: The correlation of S100 expression in DCs with histological grading was significant (p=0.049). We also observed a correlation between CD1a expression and histological grading (p=0.016). DCs density was predominantly intratumoral for both CD1a (63% of cases) and S100 protein expression (25% of cases). Conclusion: Our results demonstrated the association of DCs with histological grade. Their intratumoral infiltration suggests their potential antitumor role.

Chemoradiotherapy and Lymph Node Metastasis Affect Dendritic Cell Infiltration and Maturation in Regional Lymph Nodes of Laryngeal Cancer

“…In a previous study conducted in our laboratory, CD1a-DCs were found to be associated with unfavorable clinical outcomes in patients with advanced laryngeal cancer who had undergone total laryngectomy as the initial treatment [23]. However, only a small number of studies have focused on DC infiltration into laryngeal cancer tissue, but the results differed [24][25][26][27][28][29]; thus, the role of DC infiltration in laryngeal cancer remains unclear.…”