Profile of Acute Coronary Syndrome In Young People: A Hospital Based Observational Study in Western Nepal

Paudel, Naba R.; Alurkar, Vijay Madhav; Jha, Girija Shankar; Kafle, Ramchandra; Sapkota, Subash; Lamsal, Lekhnath

doi:10.3126/bjhs.v3i1.19759

Cited by 5 publications

(8 citation statements)

References 18 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Smoking was seen as commonest risk factor out of the other conventional risk factors in other studies too. [14][15][16]21 This was followed by hypertension (52%), Dyslipidemia (50%), Diabetes (18%) and Obesity ( and India 22 showed 55 % and 48 % respectively which is similar to our study. We had patients with higher dyslipidemics than other studies like INTERHEART South Asian Cohort 20 and a study form Bangladesh.…”

Section: Procedures Cag Pci (N=588) Totalsupporting

confidence: 88%

“…The patients with young ACS comprises from 8-13% around the globe including Nepal. [10][11][12][13][14][15][16] The most common risk factor in patients with ACS was smoking (71%). Smoking was seen as commonest risk factor out of the other conventional risk factors in other studies too.…”

Section: Procedures Cag Pci (N=588) Totalmentioning

confidence: 99%

“…9 Roughly two-thirds of patients with MI have NSTEMI; the rest have STEMI. 10 Meanwhile, we have limited data on the nature and distribution of ACS in Nepal [11][12][13][14][15][16] and moreover no data is available in this part of country.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Profile and Outcomes of Patients Undergoing Percutaneous Coronary Intervention: A 5 Year Experience

Paudel

2021

J Coll Med Sci-Nepal

Self Cite

View full text Add to dashboard Cite

Introduction: Ischemic Heart Disease is the leading cause of mortality and morbidity in the world. Among the ACS, the mortality rate is highest for ST Elevation Myocardial Infarction. Primary Percutaneous Coronary Intervention has emerged as the therapy of choice with better outcomes. In this study we have studied the profile and outcomes of patients with coronary artery diseases in our part of world. Methods: A retrospective, cross-sectional study was done in the department of medicine (cardiology unit) of Manipal Teaching Hospital, Pokhara. All the cases undergone PCI were taken and analyzed accordingly for the clinical profile and outcomes within the hospital stay from April 2015 to March 2020 (5 years). The data was collected in a preformed proforma and was entered in excel sheet and analyzed using SPSS software version 21. Various statistical tools were used accordingly and p values were considered significant at a predetermined alpha level of 5%. Results: The total number of procedures done for coronary arteries in Cath lab for 5 years were 2602 of which 2014 were angiographies and 588 were percutaneous coronary interventions/ angioplasties. The male-female ratio was 2.01. Out of 588 angioplasties, 326 were primary. Fifty-five percent of patients undergone angioplasties were age more than 65. Twelve percent of patients with acute coronary syndromes were young (less than 40 years of age). Smoking was the commonest risk factor (71%) followed by hypertension (52%), Dyslipidemia (50%) and Diabetes (18%). Anterior wall myocardial infarction involving left anterior descending artery was the commonest presentation. Right radial artery was the preferred route for procedure (69%) followed by right femoral artery (22%). Fourteen patients (2.3% of total, 5.0% in Primary) died. Most of the deaths were patients having anterior wall STEMI involving LAD with high TIMI scores (>6) (P: 0.0003). Conclusions: Ischemic heart disease is the commonest cause of mortality worldwide. In our study population, there was male preponderance. ST Elevated MI was the most common presentation of acute coronary syndrome and almost 85% cases posted for primary angioplasty. LAD was the most common artery causing IHD and also was significantly associated with high TIMI score and mortality. ACS in young is alarmingly increasing in this part of world probably associated with increased rates of smoking in younger population.

show abstract

Section: Procedures Cag Pci (N=588) Totalsupporting

confidence: 88%

Section: Procedures Cag Pci (N=588) Totalmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Profile and Outcomes of Patients Undergoing Percutaneous Coronary Intervention: A 5 Year Experience

Paudel

2021

J Coll Med Sci-Nepal

Self Cite

View full text Add to dashboard Cite

show abstract

“…These findings are similar to a few other studies even in patients with young acute coronary syndromes where smoking was found to be the major risk factor along with hypertension, diabetes, and dyslipidemia. [16][17][18][19] There was a significant association between smoking (OR: 11.5, p:0.005), hypertension (OR:8.5, p: 0.002), and diabetes (OR: 10, p: 0.001). Similar results are seen in other studies too and there are studies where smoking and diabetes are commonly associated with multivessel diseases.…”

Section: Resultsmentioning

confidence: 99%

Study to Evaluate Coronary Artery Disease Prevalence and Risk Factors in Heart Failure Patients with Reduced Ejection Fraction

Paudel

Thapa

2022

Nep J Med Sci

View full text Add to dashboard Cite

Introduction: Even though heart failure (HF) is a major global health problem, studies on the prevalence and etiology of HF in Nepal are scant. The aim of this study was to assess the prevalence and risk factors of coronary artery disease (CAD) in HF with reduced ejection fraction (HFrEF) using invasive coronary angiography (CAG). Methods: This was a prospective, cross-sectional, descriptive observational study conducted from July 2020 to September 2021. All consecutive patients with HFrEF who met the inclusion criteria underwent CAG at Manipal Teaching Hospital were evaluated and analyzed using various statistical tools. Results: Total 108 patients with a male to female ratio of 2.02:1 were assessed. The mean age of patients was 63+6.08 years. The prevalence of CAD was 72% of which 42% were having significant CAD (stenosis >50%) with 45%, 32% and 23% having triple (TVD), double (DVD) and single vessel disease (SVD) respectively Smoking was the commonest risk factor (61%) followed by hypertension (52%), dyslipidemia (27%) and diabetes (22%). The prevalence of CAD increased with increase in the number of risk factors. There was significant association of smoking (OR: 11.5, P: 0.005), hypertension (OR: 8.5, P: 0.002) and diabetes (OR: 10, P: 0.001) for occurrence of significant CAD. Conclusion: In our study, otherwise unexplained HFrEF showed overall 72% of CAD with 42% having significant CAD (stenosis >50%). Conventional risk factors like smoking, hypertension and diabetes were significantly associated with development of CAD.

show abstract

“…were hypertensive with 14 % diabetic and diabetes was associated with multivessel disease and poor prognosis [26].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular risk factors and clinical pattern in young Nepalese population with acute coronary syndrome presenting to a tertiary care center of Nepal

Sahi¹,

Gajurel²,

Khanal³

et al. 2020

J Cardiovasc Med Cardiol

View full text Add to dashboard Cite

Background and objectives: Cardiovascular disease is a major health problem reaching epidemic proportions. Although Acute Coronary Syndrome (ACS) is an uncommon entity in the young, it constitutes a rising burden in the socioeconomic status of the country because of its impact on the economically productive age group. Early identifi cation and control of the cardiovascular risk factors helps to prevent cases of Myocardial Infarction (MI) in young resulting in reduced health burden. Therefore, we aimed to assess clinical pattern and the prevalence of cardiovascular risk factors in the young and economically productive population of an underdeveloped country to lower the socioeconomic burden. Methods: A total of 60 patients presenting at the cardiology department of Manmohan Cardiothoracic Vascular and Transplant Center were included in our study after fulfi lling the inclusion criteria. ACS was diagnosed by cardiac enzymes, electrocardiography, and echocardiography and coronary intervention was done in the cardiac catheterization room. Patients were followed up at 1 and 3-months and reassessed clinically and by echocardiography. Results: Mean age of presentation was 38.55 + 4.98 (SD) years. Over three-fourth of the patients were male (80%) and nearly three-quarter experienced ST-elevated MI (73%). Smoking was the most prevalent risk factor (67%), followed by dyslipidemia (40%), diabetes (32%), hypertension (30%), and obesity (13%). Most of the patients presented with single-vessel disease (65%), followed by double-vessel disease (18%), triple-vessel disease (12%), left main disease (3%), and minor coronary artery disease (2%). Conclusions: ACS in underdeveloped country is more common in male and single-vessel disease is the most common clinical pattern of ACS and smoking the most prevalent risk factor.

show abstract

Profile of Acute Coronary Syndrome In Young People: A Hospital Based Observational Study in Western Nepal

Cited by 5 publications

References 18 publications

Clinical Profile and Outcomes of Patients Undergoing Percutaneous Coronary Intervention: A 5 Year Experience

Clinical Profile and Outcomes of Patients Undergoing Percutaneous Coronary Intervention: A 5 Year Experience

Study to Evaluate Coronary Artery Disease Prevalence and Risk Factors in Heart Failure Patients with Reduced Ejection Fraction

Cardiovascular risk factors and clinical pattern in young Nepalese population with acute coronary syndrome presenting to a tertiary care center of Nepal

Contact Info

Product

Resources

About