Profile of children with cerebral palsy spectrum disorder and a normal MRI study

Springer, Arielle; Holzinger, Sasha Dyck; Andersen, John; Buckley, David; Kirton, Adam; Koclas, Louise; Pigeon, Nicole; Rensburg, Esias van; Wood, Ellen; Oskoui, Maryam; Shevell, Michael

doi:10.1212/wnl.0000000000007726

Cited by 21 publications

(15 citation statements)

References 38 publications

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“…Motor disorders in CP according to GMFCS and BFMF did not correlate significantly with MRI imaging. However, the non-significant association in our research is not difficult to explain, as previous research found a similar inconsistent association of motor function and brain MRI ( 16 ).…”

Section: Discussioncontrasting

confidence: 80%

The applicability of magnetic resonance imaging classification system (MRICS) for cerebral palsy and its association with perinatal factors and related disabilities in a Croatian population-based sample

Kojundžić

Mršić²,

Jelovina³

et al. 2021

Croat Med J

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Aim To investigate the association of cerebral palsy motor disorders, perinatal factors, and related disabilities with brain magnetic resonance imaging classification score (MRICS)-based groups in a population-based sample. Methods The study enrolled children with cerebral palsy born from 2003 to 2015 treated at Split University Hospital who underwent brain MRI scanning. Perinatal data (plurality, birth weight, gestational age, and Apgar score) were collected from hospital records. Motor disorders of cerebral palsy (gross and fine motor function) and the related disabilities (intellectual status, speech and eating ability, epilepsy, vision and hearing status) were evaluated with neurological status assessment. Neuroimaging findings were presented as MRICS-based groups. Results Of 115 enrolled children, an abnormal finding on brain MRI was confirmed in 95%, including white matter injury (66%), maldevelopments (13.9%), gray matter injury (9.6%), and miscellaneous findings (6.1%). Gross and fine motor function were not significantly associated with MRICS-based group. All related disabilities and perinatal factors, except Apgar score, were significantly associated with MRICS-based group. Conclusion Brain MRICS-based groups were associated with perinatal risk factors and related disabilities of cerebral palsy, but not with common motor disorders. MRI classification score is a reliable diagnostic tool, which strongly correlates with perinatal factors and related disabilities of cerebral palsy.

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Section: Discussioncontrasting

confidence: 80%

The applicability of magnetic resonance imaging classification system (MRICS) for cerebral palsy and its association with perinatal factors and related disabilities in a Croatian population-based sample

Kojundžić

Mršić²,

Jelovina³

et al. 2021

Croat Med J

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“…Two of the three infants with a normal sMRI developed spastic diplegia. A recent CP registry study found that infants with these CP subtypes were twice as likely to have normal sMRI scans 39 . Our results suggest that DWMA is pathologic and deserves further testing in larger studies to externally validate its prognostic value for the early detection of minor motor impairments and CP.…”

Section: Discussionmentioning

confidence: 99%

Novel diffuse white matter abnormality biomarker at term-equivalent age enhances prediction of long-term motor development in very preterm children

Parikh

Harpster

et al. 2020

Sci Rep

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Our objective was to evaluate the independent prognostic value of a novel MRI biomarker—objectively diagnosed diffuse white matter abnormality volume (DWMA; diffuse excessive high signal intensity)—for prediction of motor outcomes in very preterm infants. We prospectively enrolled a geographically-based cohort of very preterm infants without severe brain injury and born before 32 weeks gestational age. Structural brain MRI was obtained at term-equivalent age and DWMA volume was objectively quantified using a published validated algorithm. These results were compared with visually classified DWMA. We used multivariable linear regression to assess the value of DWMA volume, independent of known predictors, to predict motor development as assessed using the Bayley Scales of Infant & Toddler Development, Third Edition at 3 years of age. The mean (SD) gestational age of the cohort was 28.3 (2.4) weeks. In multivariable analyses, controlling for gestational age, sex, and abnormality on structural MRI, DWMA volume was an independent prognostic biomarker of Bayley Motor scores ($$\beta $$ β = −12.59 [95% CI −18.70, −6.48] R2 = 0.41). Conversely, visually classified DWMA was not predictive of motor development. In conclusion, objectively quantified DWMA is an independent prognostic biomarker of long-term motor development in very preterm infants and warrants further study.

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“…While early identification of CP can be reliably achieved through the combination of neuroimaging and motor assessments, TMS may contribute additional diagnostic and prognostic information [18]. For example, though approximately 90% of children with CP have atypical neuroimaging findings, a remaining 10% display typical findings which potentially impedes early diagnosis [19]. If identified in infancy, the absence of an MEP from the MAH may elucidate the timing and mechanism of atypical CST organization, as well as potential prognosis of anticipated functional outcomes based upon known MEP and motor outcomes in older children with CP.…”

Section: Introductionmentioning

confidence: 99%

Motor Evoked Potentials as Potential Biomarkers of Early Atypical Corticospinal Tract Development in Infants with Perinatal Stroke

Kowalski

Nemanich

Nawshin

et al. 2019

JCM

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Diagnosis of cerebral palsy (CP) after perinatal stroke is often delayed beyond infancy, a period of rapid neuromotor development with heightened potential for rehabilitation. This study sought to assess whether the presence or absence of motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) could be an early biomarker of atypical development within the first year of life. In 10 infants with perinatal stroke, motor outcome was assessed with a standardized movement assessment. Single-pulse TMS was utilized to assess presence of MEPs. Younger infants (3–6 months CA, n = 5, 4/5 (80%)) were more likely to present with an MEP from the more-affected hemisphere (MAH) compared to older infants (7–12 months CA, n = 5, 0/5, (0%)) (p = 0.048). Atypical movement was demonstrated in the majority of infants with an absent MEP from the MAH (5/6, 83%) compared to those with a present MEP (1/4, 25%) (p = 0.191). We found that age influences the ability to elicit an MEP from the MAH, and motor outcome may be related to MAH MEP absence. Assessment of MEPs in conjunction with current practice of neuroimaging and motor assessments could promote early detection and intervention in infants at risk of CP.

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Profile of children with cerebral palsy spectrum disorder and a normal MRI study

Cited by 21 publications

References 38 publications

The applicability of magnetic resonance imaging classification system (MRICS) for cerebral palsy and its association with perinatal factors and related disabilities in a Croatian population-based sample

The applicability of magnetic resonance imaging classification system (MRICS) for cerebral palsy and its association with perinatal factors and related disabilities in a Croatian population-based sample

Novel diffuse white matter abnormality biomarker at term-equivalent age enhances prediction of long-term motor development in very preterm children

Motor Evoked Potentials as Potential Biomarkers of Early Atypical Corticospinal Tract Development in Infants with Perinatal Stroke

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