Profile of collagen prolines level of anterior rectus sheath tissue in indirect inguinal hernia: A cross-sectional study

Darmadi, Suluh; Warsinggih,; Mappincara,; Hendarto, Joko; Labeda, Ibrahim; Lusikooy, Ronald Erasio; Sampetoding, Samuel; Dani, Muhammad Iwan; Kusuma, Muhammad Ihwan; Uwuratuw, Julianus Aboyaman; Syarifuddin, Erwin

doi:10.1016/j.amsu.2021.102546

Cited by 2 publications

(4 citation statements)

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“…The composition of collagen appears to affect changes in fascial and systemic tissues. Changes in collagen are also observed in patients with hernial recurrence; the amino acids that make up the main component of collagen are glycine, hydroxyproline, proline, and alanine [ 2 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…An inguinal hernia is a protrusion of the contents of the abdominal cavity through the inguinal canal due to a defect in the abdominal wall [ 1 , 2 ]. The stability of the abdominal wall depends on the integrity of muscle and fascial tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Another study found that in patients with direct inguinal hernia, the anterior rectus sheath above the defect was thinner than normal [ 4 ]. There was a decrease in the proliferation of fibroblasts and collagen and hydroxyproline content was as high as 19.2% [ 2 , 7 , 8 ]. Studies on the transverse fascia of patients with hernias have also found abnormalities in the collagen content.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between glycine levels in collagen in the anterior rectus sheath tissue and the onset of indirect inguinal hernia: A cross-sectional study

Fajar

Syarifuddin

Hendarto

et al. 2022

Annals of Medicine &Amp; Surgery

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Introduction An inguinal hernia is a protrusion of abdominal-cavity contents through the inguinal canal. Protection against an inguinal hernia depends on the integrity of fascial tissue, which is maintained by collagen. Collagen is a structural protein consisting of amino acids, the most common of which is glycine. This study aimed to determine the relationship between glycine and the appearance of lateral inguinal hernias. To this end, the researchers examined the profile of collagen and glycine levels in the tissue of the sheath of the rectus femoris in patients with lateral inguinal hernia (indirect inguinal hernia). Methods The study used a cross-sectional design to determine glycine levels in rectus anterior sheath tissue in patients with indirect inguinal hernia. Examination of collagen glycine levels was conducted using the ELISA (Enzyme-Linked immunosorbent assay) method. Data were analyzed using the Statistical Package for the Social Science (SPSS) program. An ANOVA test, Pearson's correlation test, and Spearman's correlation test were also performed. A p-value <0.05 was said to be significant. Results Across 72 samples, the mean body mass index (BMI) was 22.5 kg/m2 and, the mean clinical onset was 28.02 months. Correlation tests showed a correlation between glycine levels and clinical onset (p = 0.026). The ANOVA test showed a difference between glycine levels with age group (p = 0.025) and BMI (p = 0.015). The correlation between glycine levels and clinical-grade (p = 0.416) was not statistically significant. Conclusion There is a significant relationship between glycine levels and age, BMI, and clinical onset of indirect inguinal hernia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The relationship between glycine levels in collagen in the anterior rectus sheath tissue and the onset of indirect inguinal hernia: A cross-sectional study

Fajar

Syarifuddin

Hendarto

et al. 2022

Annals of Medicine &Amp; Surgery

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“…The study was carried out from August 2021 to October 2021. Our work is reported following the criteria of Strengthening the Reporting of Cohort Studies [9], [10].…”

Section: Methodsmentioning

confidence: 99%

Relationship of Gastroesophageal Flap Valve with Gastroesophageal Reflux Disease Assessed Based on GerdQ Scores and Endoscopic Images

Neilufar

Akil²,

Daud³

et al. 2022

Open Access Maced J Med Sci

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Background: Gastroesophageal reflux disease (GERD) is a condition where reflux of stomach contents causes troublesome symptoms or complications. The gastroesophageal flap valve (GEFV) is one of the protective structures against esophageal reflux. This study aimed to determine the relationship between GEFV, measured by Gastroesophageal Reflux Disease Questionnaire (GerdQ) scores, and the endoscopic features of GERD patients. Method: This observational cross-sectional study was performed at Wahidin Sudirohusodo Hospital Makassar from August 2021 to October 2021. The participants were GERD patients who met the inclusion criteria. They were diagnosed using GerdQ scores and endoscopic features based on the Los Angeles criteria. The GEFV was assessed using retroflection endoscopy according to Hill’s criteria. Data analysis used SPSS version 25. The Kolmogorov–Smirnov test was used to assess data normality, along with the Chi-square test and calculation of odds ratio (OR). The results of the statistical tests were significant if p<0.05. Results: This study included 100 GERD patients: 49 men and 51 women. They had a mean age of 40.5±12.8 years and a mean body mass index of 22.4±3.8 kg/m2. Abnormal GEFV was a risk for a GerdQ score of ≥8 compared to <8 (OR 4.56; 95% CI 1.53–13.52). Both normal and abnormal GEFV in esophagitis reflux were higher than in non-erosive reflux disease (p=0.943). Conclusion: Abnormal GEFV was a risk factor for GERD based on a GerdQ score of 8, at 4.56 times higher than with normal GEFV. No statistically significant relationship existed between GEFV and endoscopic images.

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Profile of collagen prolines level of anterior rectus sheath tissue in indirect inguinal hernia: A cross-sectional study

Cited by 2 publications

References 25 publications

The relationship between glycine levels in collagen in the anterior rectus sheath tissue and the onset of indirect inguinal hernia: A cross-sectional study

The relationship between glycine levels in collagen in the anterior rectus sheath tissue and the onset of indirect inguinal hernia: A cross-sectional study

Relationship of Gastroesophageal Flap Valve with Gastroesophageal Reflux Disease Assessed Based on GerdQ Scores and Endoscopic Images

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