2015
DOI: 10.1016/j.cimid.2015.05.003
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Profile of cytokines in the lungs of BALB/c mice after intra-nasal infection with Histoplasma capsulatum mycelial propagules

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Cited by 13 publications
(18 citation statements)
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“…Those genotypes could be associated with more virulent/pathogenic variants that could reflect in different disease phenotypes. Recently, studies of host-pathogen interactions using a small set of Histoplasma isolates (NAm1, NAm2, Panama and LAm A species) revealed significant differences in fungal burden, disease kinetics, disease symptoms, and cytokine response [ 97 , 98 ].…”
Section: Resultsmentioning
confidence: 99%
“…Those genotypes could be associated with more virulent/pathogenic variants that could reflect in different disease phenotypes. Recently, studies of host-pathogen interactions using a small set of Histoplasma isolates (NAm1, NAm2, Panama and LAm A species) revealed significant differences in fungal burden, disease kinetics, disease symptoms, and cytokine response [ 97 , 98 ].…”
Section: Resultsmentioning
confidence: 99%
“…Limited data from human studies have identified polymorphisms in the IL-10 gene associated with increased susceptibility to invasive candidiasis [83], whereas polymorphisms in the IL-10 promoter have been associated with either resistance or susceptibility to invasive pulmonary aspergillosis [84]. In murine studies, IL-10 expression also occurs in response to murine infection with C. albicans [85], H. capsulatum [86] and A. fumigatus [87] and the absence of IL-10 is associated with improved fungal clearance. In particular, intravenous infection with C. albicans is quickly cleared in IL-10 −/− mice compared to wild-type mice, which is attributed to more efficient fungal killing by neutrophils [85].…”
Section: Immunoregulatory Signaling Pathwaysmentioning
confidence: 99%
“…Furthermore, Sepúlveda et al ( 2014 ) compared H. capsulatum strains with distinct genotype and virulence and noted that strain G-217B exhibited delayed response to the virulence effect, as in macrophage damage and cytokine production when compared to other strains. Likewise, Sahaza et al ( 2015 ) highlighted that lung inflammatory responses, in regard to cytokine profile and lung-granuloma formation, varied in intensity and time when two different virulent H. capsulatum strains from distinct phylogenetic species, EH-46 (LAm A) and G-217B (NAm 2), were used. Our data corroborated those reported by Sepúlveda et al ( 2014 ) and Sahaza et al ( 2015 ), as strain G-217B showed delayed infection potential against host cells.…”
Section: Discussionmentioning
confidence: 99%
“…Likewise, Sahaza et al ( 2015 ) highlighted that lung inflammatory responses, in regard to cytokine profile and lung-granuloma formation, varied in intensity and time when two different virulent H. capsulatum strains from distinct phylogenetic species, EH-46 (LAm A) and G-217B (NAm 2), were used. Our data corroborated those reported by Sepúlveda et al ( 2014 ) and Sahaza et al ( 2015 ), as strain G-217B showed delayed infection potential against host cells.…”
Section: Discussionmentioning
confidence: 99%