Profile of nonmotor symptoms and the association with the quality of life of Parkinson's disease patients in Nigeria

Arabambi, Babawale; Oshinaike, Olajumoke; Ogun, SA

doi:10.4103/nmj.nmj_119_19

Cited by 4 publications

(14 citation statements)

References 35 publications

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“…The majority of the participants had H & Y stage 1 to 3; indicating mild to moderate disease stage in PD patients in Addis Ababa. This results were consistent with global and regional reports( 11 , 12 ). These results highlights the burden of disease most of our PD patients were suffering from; and further support the need to optimize our care to diagnose and manage PD much earlier.…”

Section: Discussionsupporting

confidence: 93%

“…The non-motor symptoms have tendency to manifest years before the motor features appears; and often associated with increased disability and low quality of life in PD patients ( 9 , 10 ). According to recent reports: neuropsychiatric, gastrointestinal symptoms, and cognitive impairments were the commonest NMSs features reported by African PD patients ( 11 – 14 ). Understanding the non-motor phenotypes of patients with PD in Ethiopia will contribute to the ongoing PD-specific clinical care improvement effort in Ethiopia; and also, it will contribute to the global effort, which aims in understanding the phenotypical and genotypic variation observed between PD patients with different ethnicity, especially those with African ancestors.…”

Section: Introductionmentioning

confidence: 98%

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Non-Motor Symptoms and Associated Factors in Parkinson’s Disease Patients in Addis Ababa, Ethiopia: A Multicenter Cross-Sectional Study

Ayele

Zewde

Tafesse

et al. 2021

Ethiop J Health Sci

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BACKGROUND: Non-motor symptoms (NMSs) of Parkinson’s disease (PD) were often overlooked and less studied. Little is known about NMSs in Ethiopia. The aim of the study was to determine the prevalence of NMSs and associated factors.METHODS: A multi-center cross-sectional observational study was conducted. NMS questionnaire was used to screen for the NMSs. Both descriptive and analytical statistics were used to analyze the data.RESULTS: Total of 123 PD patients with median of 4 years were investigated. The mean age of PD patients was 62.9 years. The mean age of PD onset was 58.3 years. In 23.6% the age of onset was below age 50. Males accounted 72.4%. Majority of the patients were on Levodopa alone and 31.7% were on levodopa plus trihexyphenidyl. Longer duration of illness was associated with frequent occurrence of NMSs. Constipation was the commonest NMS (78%), followed by urinary urgency (67.5%) and nocturia (63.4%). An unexplained pain was reported by 45.5%, cognitive impairment (45.5%), and sleep disturbance was reported by 45.5% of the study participants. Neurophysciatric symptoms were reported by small proportion of the patients. Lower monthly earning was associated with swallowing problem, unexplained weight change, and lighheadness.CONCLUSION: The prevalence of NMS was high among PD patients in Ethiopia. Constipation was the commonest NMS. Longer duration of illness was associated with frequent occurrence of NMSs. Lower monthly earning was associated with swallowing problem, unexplained weight change, and lighheadness.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Non-Motor Symptoms and Associated Factors in Parkinson’s Disease Patients in Addis Ababa, Ethiopia: A Multicenter Cross-Sectional Study

Ayele

Zewde

Tafesse

et al. 2021

Ethiop J Health Sci

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“…Furthermore, the frequency of constipation, urinary urgency, and nocturia was significantly higher among Parkinson's disease patients compared to the healthy control group. This is congruent to previous reports ( 5 , 7 , 10 , 16 , 18 , 27 ). According to a previous similar study by Biniyam et al, the prevalence of constipation and urinary urgency was 78% and 67.5% respectively ( 15 ).…”

Section: Discussionsupporting

confidence: 93%

“…Patients with PD should be screened regularly for an orthostatic hypotension during their routine follow up evaluation. OH, is defined as sustained decrease in systolic blood pressure (SBP) ≥ 20 mmHg and/or diastolic blood pressure (DBP) 10 mmHg within 3 min of standing ( 2 , 10 , 14 , 16 – 18 ).…”

Section: Introductionmentioning

confidence: 99%

Frequency and Factors Associated with Orthostatic Hypotension in Individuals with Parkinson’s Disease: A Case-Control Observational Study

Mengesha

2022

Ethiop J Health Sci

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BACKGROUND: Orthostatic hypotension (OH) is a common and considered the most incapacitating non-motor symptom of Parkinson’s disease (PD). Little is known about OH in Ethiopian PD patients. The objectives of the present study were to determine the frequency and factors associated with OH in individuals diagnosed with PD compared to a healthy control. Methods: A multi-center case-control observational study was conducted. A total of 53 PD cases and 53 age and sex matched healthy controls were included. Both descriptive and Chi-square proportional statistical analysis were used. RESULTS: The mean age distribution was comparable between the two study groups (61.9 vs. 59.9 years). Distribution of male gender was comparable between PD and control groups (71.7% vs. 67.9%). Nearly all the individuals diagnosed with PD were on levodopa treatment, and close to half of them were on anticholinergic drugs. Hypertension was the commonest comorbid disorder in both groups. The prevalence of orthostatic hypotension was higher in PD patients (22.6%) compared to the control group (9.4%). The proportion of constipation (p=0.007), urinary urgency (p=0.007), and nocturia (p<0.0001) was significantly higher among Parkinson’s disease patients compared to the healthy control group. Falls and excessive sweating were only reported by PD patients. CONCLUSION: The present study shows the frequency of orthostatic hypotension in Ethiopian Parkinson’s disease patients is comparable to other regions. The presence of constipation, urinary urgency, and nocturia was associated with Parkinson’s disease compared to the control group.

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“…Four studies involved centres in China (Lee et al , 2015) [40] [41] [42] and two in Korea[43] [44] Two studies were conducted in India [45] [46]. In addition, one study was conducted in each of the following countries: United Kingdom (UK) [47], Spain [48], Egypt [49], Nigeria [50]), Singapore [51], Taiwan [52], Malaysia[53], Estonia [37], [38]Slovakia[54]Turkey [55], Iran[56]and Mexico ([57] Studies characteristics were included in table 1 .…”

Section: Resultsmentioning

confidence: 99%

Ethnicity as a predictor of nonmotor symptoms impact on quality of life in patients with Parkinson’s disease: A systematic review

Aldeen,

Houlden,

Rizig

2023

Preprint

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BackgroundParkinson’s disease (PD) is a chronic progressive hypokinetic movement disorder characterised by rigidity, tremor, and bradykinesia in addition to multiple non-motor features. It is increasingly recognised that NMS have a substantial impact on the quality of life (QoL) of people with PD, more than motor features. The prevalence and types of these NMS vary among PD patients from different ethnic groups. Ethnicity has been postulated as a determinant of PD symptoms and quality of life of people with PD. There is paucity of data on the effect of ethnicity on (QoL) of people with PD.AimThe aim of this review is to critically evaluate the literature to (1) identify the variability of NMS that affect QoL of people with PD from different ethnicities, and (2) to examine if ethnicity could determine the impact of these NMS on the QoL of people with PD.MethodsThis review was conducted according to recommendations in preferred reporting Items for Systematic Review and Meta-Analysis (PRISMA). Search was conducted in three databases (PubMed, Ovid Embase and Scopus) in the period between March & July 2023. NMS were assessed by four scales: NMSS, NMQT, MDS-UDPRS I, and HADS. QoL was assessed by PDQ39. Ethnicity has been defined based on the country where the study has been conducted. A best-evidence synthesis was used to summarise the demographics, study designs, NMS features in each ethnic group. The impact of NMS features on QoL in different ethnic groups was assessed by comparing the power of correlations measures between NMS domains and QoL in all studies.ResultsTwenty-one studies with 4246 patients were deemed suitable to be included. Patients in the selected studies were grouped to eight ethnic populations: Caucasian, East Asian, Indian, North African, West African, Hispanic, Mediterranean, and Middle Eastern ethnicities. Heterogeneous protocols and varied statistical methodologies were used in most studies to assess the relation between NMS and QoL of people with PD. Overall depression, fatigue, and sleep and memory problems are the symptoms with the most significant impact on QoL of majority of ethnic populations. Other NMS including cardiovascular, gastrointestinal and urinary Symptoms exhibited a variability in their impact on QoL in different ethnic groups.ConclusionOur study demonstrates that ethnicity may have a significant impact on the correlation between NMS and QoL of patients with PD. There is deficiency in studies assessing the impact of PD NMS on QoL in Africans, Latin Americans, and Middle Eastern populations. Ethnicity is poorly defined and frequently unaddressed in PD studies. Large multicentre, multinational multi-ethnic studies using rigorous unified protocols are required to properly evaluate the effect of ethnicity on PD NMS. Identification of these variabilities is crucial to aid efficient health policy planning based on each population needs and optimize use of local resources.

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Profile of nonmotor symptoms and the association with the quality of life of Parkinson's disease patients in Nigeria

Cited by 4 publications

References 35 publications

Non-Motor Symptoms and Associated Factors in Parkinson’s Disease Patients in Addis Ababa, Ethiopia: A Multicenter Cross-Sectional Study

Non-Motor Symptoms and Associated Factors in Parkinson’s Disease Patients in Addis Ababa, Ethiopia: A Multicenter Cross-Sectional Study

Frequency and Factors Associated with Orthostatic Hypotension in Individuals with Parkinson’s Disease: A Case-Control Observational Study

Ethnicity as a predictor of nonmotor symptoms impact on quality of life in patients with Parkinson’s disease: A systematic review

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