Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event: Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Milman, Anat; Andorin, Antoine; Gourraud, Jean‐Baptiste; Postema, Pieter G.; Sacher, Frédéric; Mabo, Philippe; Kim, Sunghwan; Juang, Jimmy J.M.; Maeda, Shingo; Takahashi, Yoshihide; Kamakura, Tsukasa; Aiba, Takeshi; Conte, Giulio; Sarquella‐Brugada, Georgia; Leshem, Eran; Rahkovich, Michael; Hochstadt, Aviram; Mizusawa, Yuka; Arbelo, Elena; Huang, Zhengrong; Denjoy, Isabelle; Giustetto, Carla; Wijeyeratne, Yanushi D.; Napolitano, Carlo; Michowitz, Yoav; Brugada, Ramón; Casado-Arroyo, Rubén; Champagne, Jean; Calò, Leonardo; Tfelt-Hansen, Jacob; Priori, Silvia G.; Takagi, Masahiko; Veltmann, Christian; Delise, Pietro; Corrado, Domenico; Behr, Elijah R.; Gaïta, Fiorenzo; Yan, Gan‐Xin; Brugada, Josép; Leenhardt, Antoine; Wilde, Arthur A.M.; Brugada, Pedro; Kusano, Kengo; Hirao, Kazuyuki; Nam, Gi‐Byoung; Probst, Vincent; Belhassen, Bernard

doi:10.1016/j.hrthm.2018.01.014

Cited by 65 publications

(35 citation statements)

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“…Western and Asian countries 1,13,14 . The present study sought to compare the clinical, electrocardiographic (ECG), electrophysiologic (EP) and genetic characteristics of White and Asian patients participating in SABRUS.…”

Section: Sabrus Is a Multicenter Survey Of First Aes Documented In 67mentioning

confidence: 99%

Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome

et al. 2019

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Background There is limited information on ethnic differences between patients with Brugada syndrome (BrS) with arrhythmic events (AEs). Objectives To compare clinical, electrocardiographic (ECG), electrophysiologic (EP) and genetic characteristics between White and Asian BrS-patients with AE. Methods SABRUS is a multicenter survey from Western and Asian countries, gathering 678 BrSpatients with first documented AE. After excluding patients with other (n=14; 2.1%) or unknown (n=30; 4.4%) ethnicity, 364 (53.7%) Whites and 270 (39.8%) Asians comprised the study group. Results There was no difference in AE age onset (41.3±16.1 years in Whites vs. 43.3±12.3 years in Asians, P=0.285). Higher proportions of Whites were observed in pediatric and elderly populations. Asians were predominantly males (98.1% vs. 85.7% in Whites, P<0.001) and frequently presented with aborted cardiac arrest (ACA) (71.1% vs. 56%, P<0.001). Asians tended to display more spontaneous type 1 BrS-ECG (71.5% vs. 64.3%, P=0.068). Family history of sudden cardiac death (FHSCD) was noted more in Whites (29.1% vs. 11.5%, P<0.001), with higher rate of SCN5A mutation carriers (40.1% vs. 13.2% in Asians, P<0.001), as well as more fever-related AEs (8.5% vs. 2.9%, 0.011). No difference was observed between the two groups regarding prior history of syncope and ventricular arrhythmia inducibility. Conclusions There are important differences between Asian and White BrS-patients. Asian patients present almost exclusively as male adults, more often with ACA and spontaneous type 1 BrS-ECG. However, they have less FHSCD and markedly lower SCN5A mutation rates. The striking difference in SCN5A mutation rates should be tested in future studies.

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Section: Sabrus Is a Multicenter Survey Of First Aes Documented In 67mentioning

confidence: 99%

Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome

et al. 2019

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“…[5][6][7][8] We recently reported the results of a multicenter international survey on AE in BrS (SABRUS) on a large cohort of 678 BrS-patients with their first ever documented AE, including 59 females. 9,10 The present study sought to compare males and females in the SABRUS patient population.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients

et al. 2018

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“…Electrocardiographic indices may be of predictive value but are limited by the dynamic nature of conduction or repolarization abnormalities (Tse et al, 2017;Deliniere et al, 2019). Although BrS is found to be associated with genetic mutations, notably in the SCN5A gene, the low prevalence of genetic testing (∼25%) and heterogeneity in patients' genetic profile restricts its application in risk stratification (Milman et al, 2018;.…”

Section: Introductionmentioning

confidence: 99%

Outcomes in Brugada Syndrome Patients With Implantable Cardioverter-Defibrillators: Insights From the SGLT2 Registry

Lee¹,

Zhou

et al. 2020

Front. Physiol.

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Background and Objectives: Brugada syndrome (BrS) is a cardiac ion channelopathy with characteristic electrocardiographic patterns, predisposing affected individuals to sudden cardiac death (SCD). Implantable cardioverter-defibrillator (ICD) is used for primary or secondary prevention in BrS, but its use remains controversial amongst low-risk asymptomatic patients. The present study aims to examine indicators for ICD implantation amongst BrS patients with different disease manifestations. Methods: This study included BrS patients who received ICDs between 1997 and 2018. The cohort was divided into three categories based on presentations before ICD implantation: asymptomatic, syncope, ventricular tachycardia/ventricular fibrillation (VT/VF). Univariate and multivariate Cox-regression analysis were performed to identify independent predictors of appropriate and inappropriate shock delivery. Results: A total of 136 consecutive patients were included with a median follow-up of 95 (IQR: 80) months. Appropriate shocks were delivered in 34 patients (25.0%) whereas inappropriate shocks were delivered in 24 patients (17.6%). Complications occurred in 30 patients (22.1%). Type 1 Brugada pattern were found to be an independent predictor of appropriate shock delivery, whilst the presence of other arrhythmia was predictive for both appropriate and inappropriate ICD shock delivery under multivariate Cox regression analysis. Conclusion: ICD therapy is effective for primary and secondary prevention of SCD in BrS. Whilst appropriate shocks occur more frequently in BrS patients presenting with VT/VF, they also occur in asymptomatic patients. Further research in risk stratification can improve patient prognosis while avoid unnecessary ICD implantation.

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Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event: Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Cited by 65 publications

References 22 publications

Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome

Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome

Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients

Outcomes in Brugada Syndrome Patients With Implantable Cardioverter-Defibrillators: Insights From the SGLT2 Registry

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