Profile of patients with pulmonary non-tuberculous mycobacterial disease mimicking pulmonary tuberculosis

Drug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome

“…We had used the MIC breakpoints for drugs INH (0.2 μg/ml), RIF (1.0 μg/ml), and EMB (5.0 μg/ml) in the PST method for the isolates initially and published it earlier. [ 15 ] The resistance pattern evaluated showed a higher number of patients with INH resistance (20) followed by EMB resistance (10). For extended DST (for antibiotics other than INH, RIF, and EMB), the interpretations from the Sensititre testing method were used.…”

“…The procedures of sample collection and sample processing have been published elsewhere. [ 15 ] In brief, three consecutive sputum samples were collected and processed by N-acetyl-L-cysteine-sodium citrate-NaOH (NALC-NaOH)[ 16 ] method for smear and culture of AFB. The growth was subjected to a rapid immunochromatographic test (ICT, TBC ID, Becton Dickinson, Sparks, MD, USA) for differential identification of MTB as per standard protocol.…”

“…[ 13 14 ] We recently reported a profile of NTMs that were isolated from a cohort of adults with symptomatic pulmonary disease. [ 15 ] In this cohort, M. kansasii was isolated from sputum specimens in 46.8% (22/47) of patients with presumptive pulmonary tuberculosis (TB). In this study, we aimed to determine the drug susceptibility pattern of the M. kansasii strains using SLOWMYCO Sensititre plates (TREK DIAGNOSTIC Systems Ltd., UK) and correlate it with the clinical outcome.…”

Non-tuberculous Mycobacteria Infection: A Neglected Disease in Bangladesh

“…Compared to Pakistan and Bangladesh, where there have been few publications on NTM, numerous studies have been published from India. [25][26][27][28][29][30][31] In northern India, pulmonary NTM is predominantly caused by M. intracellulare and MAC, followed by M. abscessus; whereas extrapulmonary disease is mostly caused by M. abscessus. 26 However, in a study conducted by Maurya et al, M. fortuitum was found to be the most common organism isolated from extrapulmonary samples in northern India, followed by M. intracellulare, and M. abscessus.…”

“…28 In the south Indian state of Tamil Nadu, Gomathy et al found M. kansasii as the most abundant isolate among patients with pulmonary NTM, followed by M. intracellulare and M. abscessus. 29 A retrospective analysis of clinical specimens in Chennai established M. chelonae as the most abundant NTM species, followed by M. fortuitum. 30 Another retrospective study in India, conducted on 877 patients with suspected TB, observed an NTM prevalence of 3.8%, which included 19 pulmonary and 15 extrapulmonary cases of NTM.…”