Profiles of current COVID-19 vaccines

Heinz, Franz X.; Stiasny, Karin

doi:10.1007/s00508-021-01835-w

Cited by 41 publications

(95 citation statements)

References 87 publications

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“…The COVID-19 has caused huge impacts on all of people’s lives and healthcare systems. There is no specific cure method for the disease, although several kinds of vaccines are meanwhile available [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of COVID-19 pandemic on outpatient appointments of rheumatic patients in a non-outbreak area of China

Xie

Wang

et al. 2021

Wien Klin Wochenschr

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Summary Background Coronavirus disease 2019 (COVID-19) infection has caused huge impacts on all of people’s lives and health systems. In response to the COVID-19 pandemic, China was the first country to impose lockdown. We aimed to study the influence of COVID-19 on the outpatient visits of rheumatic patients in a non-outbreak area of China. Methods We selected three provincial or ministerial hospitals in Jinan, and collected the outpatient appointments data in rheumatology and immunology departments during the Shandong Province first-level public health emergency response period from 25 January 2020 to 8 March 2020. Results In the early stage, the number of outpatient appointments in the rheumatology and immunology departments of the three provincial or ministerial hospitals were significantly reduced, and gradually restored in the late stage. It showed that in the face of major infectious diseases, strict quarantine measures with the cooperation of the public not only controls the epidemic in a short time, but also lifts the quarantine measures and opens general outpatient clinics in hospitals as soon as possible, thus minimizing the impact on other patients. Interpretation The impact on the western hospital was greater than that on the Chinese medicine hospital, and the impact on the back-up designated hospitals for COVID-19 was the greatest. Online appointment can reduce the risk of infection in outpatients, but not completely solve the follow-up problem of rheumatic patients. Telemedicine provides a new solution for both management of rheumatic patients and control of COVID-19.

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Section: Introductionmentioning

confidence: 99%

Impact of COVID-19 pandemic on outpatient appointments of rheumatic patients in a non-outbreak area of China

Xie

Wang

et al. 2021

Wien Klin Wochenschr

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“…As stated elsewhere, the interaction between the RBD of the spike (S) protein and the hACE-2 augments the viral fusion into the host [ 34 ]. The positions of the amino acid residues within the S protein are also important since their mutations may lead to the generation of SARS-CoV-2 variants [ 34 , 35 ]. Within the S protein, the extracellular N-terminus domain, the S1 subunit, the S2 subunit, the fusion peptide (FP), the heptapeptide repeat sequence 1 (HR1), the HR2 sequence, a transmembrane (TM) domain spanning across the viral membrane, and an intracellular C-terminal domain have been studied well [ 27 , 36 ].…”

Section: Major Drugs and Their Effectiveness Against Sars-cov-2mentioning

confidence: 99%

“…Within the S protein, the extracellular N-terminus domain, the S1 subunit, the S2 subunit, the fusion peptide (FP), the heptapeptide repeat sequence 1 (HR1), the HR2 sequence, a transmembrane (TM) domain spanning across the viral membrane, and an intracellular C-terminal domain have been studied well [ 27 , 36 ]. Indeed, the RBD within the S1 subunit binds to the hACE2 receptor; and FP mediates the anchoring of the target membrane [ 27 , 35 , 36 ]. Thus, the S1 and FP sites are of great interest for the study of the drug/vaccine development as they serve as potential targets.…”

Section: Major Drugs and Their Effectiveness Against Sars-cov-2mentioning

confidence: 99%

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A Review on the Effectivity of the Current COVID-19 Drugs and Vaccines: Are They Really Working Against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants?

Noor

2021

Curr Clin Micro Rpt

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Purpose of Review In order to eradicate the COVID-19 pandemic, scientists around the world have been working very hard for a year or more with the motto of designing effective drugs and vaccines against the severe acute respiratory coronavirus 2 (SARS-CoV-2). Along with the positive results with the antiviral drugs and a few commercialized vaccines, the unresponsiveness as well as some side effects of such therapies have also been noticed, possibly due to the emergence of the SARS-CoV-2 variants. Therefore, current review summarized the actual effectiveness of the antivirals and vaccines which are in current use for the treatment of the COVID-19 patients. Recent Findings So far, some drugs have been found with hopeful results among which remdesivir and arbidol are with momentous clinical progress. Besides drug designing, vaccine development has been a major effort whereby the mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) vaccines showed the required efficacy and have been approved by the US Food and Drug Administration (USFDA). Summary While a number of existing/repurposed/repositioned or new drugs and the currently used commercial vaccines against SARS-CoV-2 apparently seem to be effective against COVID-19 mitigation, the new variants of the virus as well as the recently increased cases raised the doubt about the usefulness of these agents. Current review figured out the efficacy of different drugs and vaccines in terms of their action potential against SARS-CoV-2 and further recommended some useful measures which may be useful for future remedies.

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“…Currently, there are several vaccines approved by distinct regulatory bodies for mass vaccination. WHO issued Pfizer, Astrazenca/Oxford and Ad26.CoV2.S vaccines, working with partners for safe and effective vaccine equity for billions of people [78].…”

Section: 4present Containment Strategies Of All Outbreaksmentioning

confidence: 99%

Parallel Outbreaks of Deadly Pathogens (SARS-CoV-2, H5N8, EVD, Black fungi) around the World in 2021: Priorities for Achieving Control with Socio-Economic and Public Health Impact

Khan¹,

Nt²,

Nn³

et al. 2021

Preprint

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Concurrent waves of Coronavirus disease, Ebola virus disease, avian influenza A and black fungus are jeopardizing the lives in some parts of Africa and Asia. From this point of view, this review aims to summarize both socio-economic and public health implications of these parallel outbreaks along with their best possible management approaches. Various online databases were used to collect the necessary information regarding these outbreaks. Based on the reports published and analyses done so far, the long-lasting damages caused by these simultaneous outbreaks on global socio-economical and public health status can be conceived from the past experiences of outbreaks, especially the COVID-19 pandemic. Moreover, prolonged restrictions by the local government may lead to food insecurity, global recession, and an enormous impact on the mental health of people of all ages, specifically in developing countries. Such overwhelming effects already have been reported to be declining national growth of the economy as well as increasing political insecurity and shortage of basic needs. Although various actions have already been taken including vaccination, clinical management, and further research, social distancing, and lockdown, etc. to improve the situation, the emerging variants and associated genetic mutations may make the containment difficult worsening the situation again. Considering the current mutational dynamics of the pathogens and the past experiences, perpetual preparedness along with updated clinical management backed by epidemiological studies and innovating scientific effort are inevitable to combat the simultaneous waves of multiple infectious diseases.

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Profiles of current COVID-19 vaccines

Cited by 41 publications

References 87 publications

Impact of COVID-19 pandemic on outpatient appointments of rheumatic patients in a non-outbreak area of China

Impact of COVID-19 pandemic on outpatient appointments of rheumatic patients in a non-outbreak area of China

A Review on the Effectivity of the Current COVID-19 Drugs and Vaccines: Are They Really Working Against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants?

Parallel Outbreaks of Deadly Pathogens (SARS-CoV-2, H5N8, EVD, Black fungi) around the World in 2021: Priorities for Achieving Control with Socio-Economic and Public Health Impact

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