2023
DOI: 10.1016/j.arcmed.2022.12.007
|View full text |Cite
|
Sign up to set email alerts
|

Profiles of Expression of SAV1 in Normoxia or Hypoxia Microenviroment are Associated with Breast Cancer Prognosis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
5
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(5 citation statements)
references
References 23 publications
0
5
0
Order By: Relevance
“…In our study, we observed no significant association between the SAV1 mRNA expression levels and the clinicopathological features of the CRC patients, and the SAV1 mRNA and protein levels were not significantly correlated with the patients' overall survival. In contrast, SAV1 mRNA upregulation in breast cancer was associated with a better survival probability [14], and the elevated expression of the SAV1 protein in pancreatic ductal adenocarcinoma was a significant favorable prognostic factor of overall survival [13].…”
Section: Discussionmentioning
confidence: 98%
See 2 more Smart Citations
“…In our study, we observed no significant association between the SAV1 mRNA expression levels and the clinicopathological features of the CRC patients, and the SAV1 mRNA and protein levels were not significantly correlated with the patients' overall survival. In contrast, SAV1 mRNA upregulation in breast cancer was associated with a better survival probability [14], and the elevated expression of the SAV1 protein in pancreatic ductal adenocarcinoma was a significant favorable prognostic factor of overall survival [13].…”
Section: Discussionmentioning
confidence: 98%
“…Matsuura et al [15] found that SAV1 downregulation at the protein level was correlated with tumor grade occurring preferentially in high-grade clear cell renal cell carcinoma. An in silico analysis by de Amorim et al [14] indicated SAV1 upregulation at the mRNA and protein levels in the early stages of breast cancer. In our study, we observed no significant association between the SAV1 mRNA expression levels and the clinicopathological features of the CRC patients, and the SAV1 mRNA and protein levels were not significantly correlated with the patients' overall survival.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Accumulating evidence has depicted that aberrant activation of Yes-associated protein (YAP), a downstream transcriptional co-activator of the Hippo pathway, stimulates cell proliferation, leading to tissue or organ hyperplasia and tumorigenesis 7 . Under normal physiological conditions, activation of upstream Salvador homolog1 (SAV1) 8 , mammalian Ste20-like 1 and 2 (MST1/2) 7 , large tumor suppressor 1 and 2 (Lats1/2) 9 , and MOB kinase activator 1 (MOB1) in the Hippo pathway promotes YAP phosphorylation and degradation. The inhibition of Hippo signaling promotes YAP's nuclear translocation, where it binds to TEA domain transcription factor1/4 (TEAD1/4) to induce the transcription of genes involved in proliferation and migration, such as connective tissue growth factor (CTGF) and cysteine-rich inducer of angiogenesis 61 (Cyr61) 9 .…”
Section: Introductionmentioning
confidence: 99%
“…Although previous studies have implicated YAP in the progression of arthritis, there are still some important connections that need to be established, such as changes in YAP activity across different species of FLSs, the correlation between altered YAP activity and abnormal proliferation of FLSs, and the mechanisms by which upstream pro-inflammatory factors regulate YAP. SAV1, a known tumor suppressor in various cancer types, exhibits downregulation in cancerous tissues or cells, thereby promoting tumor progression, cancer aggressiveness, and unfavorable prognosis 8 , 12 . However, SAV1 downregulation has not been investigated in RA, with the mechanism of expression and regulation of SAV1 in many diseases including RA remaining ambiguous.…”
Section: Introductionmentioning
confidence: 99%