“…Although previous studies have implicated YAP in the progression of arthritis, there are still some important connections that need to be established, such as changes in YAP activity across different species of FLSs, the correlation between altered YAP activity and abnormal proliferation of FLSs, and the mechanisms by which upstream pro-inflammatory factors regulate YAP. SAV1, a known tumor suppressor in various cancer types, exhibits downregulation in cancerous tissues or cells, thereby promoting tumor progression, cancer aggressiveness, and unfavorable prognosis 8 , 12 . However, SAV1 downregulation has not been investigated in RA, with the mechanism of expression and regulation of SAV1 in many diseases including RA remaining ambiguous.…”