Profiles of maternal origin factors during transition from embryonic diapause to implantation in roe deer

Korzekwa, Anna; Kotlarczyk, Angelika M.; Zadroga, Anna

doi:10.1111/asj.13289

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Studies focusing on plasma or endometrial hormone concentrations in the roe deer found little to no changes prior to implantation (Drews et al, 2019; Flint et al, 1994; Hoffmann et al, 1978; Korzekwa et al, 2019; Lambert et al, 2001; Sempéré, 1977; van der Weijden et al, 2019). In addition, corpora lutea remain active during the diapause period (Hoffmann et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Endometrial extracellular matrix components do not change over the course of embryonic diapause and reactivation in the roe deer (Capreolus capreolus)

Rüegg

Kowalewski

Ulbrich

2023

Reprod Domestic Animals

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Embryo implantation is a critical step for successful pregnancy establishment as it requires the synchronization and interaction of the developing blastocyst and the endometrium. A large percentage of unsuccessful pregnancies can be attributed to implantation failure. In cattle, around 30% of losses are thought to occur during the peri-implantation period (Wiltbank et al., 2016). Embryo implantation involves major changes within the endometrium relating to the type of placentation. In species undergoing invasive forms of implantation, including rodents, lagomorphs humans, or dogs [reviewed in (Carter, 2020) and (Kowalewski et al., 2021)], the embryo erodes the uterine epithelium and connective tissue, and thereby, comes into more intimate contact with maternal uterine structures.In ruminants, suidae and equidae, non-invasive appositioning of the embryo to the uterine epithelium gives rise to a synepitheliochorial or epitheliochorial placenta [reviewed in (Chavatte-Palmer & Tarrade, 2016)]. In any case, remodelling of the endometrial tissue to allow conceptus attachment is required. The modification of the extracellular matrix (ECM) is crucial for altering the tissue architecture (Lu et al., 2011). Moreover, the property of the ECM contributes to the distribution of growth factors and other signalling molecules (Kirkpatrick et al., 2004). Co-occurring changes in cell morphology are mediated through the cytoskeleton, which is connected to the ECM through integrin receptors and linker proteins (Whitby et al., 2020). Not surprisingly, changes in expression and/or

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Section: Discussionmentioning

confidence: 99%

Endometrial extracellular matrix components do not change over the course of embryonic diapause and reactivation in the roe deer (Capreolus capreolus)

Rüegg

Kowalewski

Ulbrich

2023

Reprod Domestic Animals

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“…Similarly, Anuradha and Krishna [62] demonstrated PRL participation during delayed embryonic development, regulating the progesterone and estradiol levels associated with luteotropic function in Cynopterus sphinx (short-nosed fruit bat). Korzekwa et al [63] showed increased progesterone and PRL serum levels, determined by ELISA and mRNA upregulation of the long PRLr isoform, in endometrial tissue during the switch from diapause to placentation in Capreolus capreolus (Roe deer). According to recent studies, PRLr content quantified by PCR is lower during diapause than during reactivation in Mustela vison (mink), the primary animal model used to evaluate diapause, uterus [64].…”

Section: Diapause: a Stage Of Embryo Development When Pluripotency Is...mentioning

confidence: 99%

Prolactin from Pluripotency to Central Nervous System Development

Martínez-Alarcón¹,

García‐López²,

Mora³

et al. 2021

Neuroendocrinology

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Prolactin (PRL) is a versatile hormone that exerts more than 300 functions in vertebrates, mainly associated with physiological effects in adult animals. Although the process that regulates early development is poorly understood, evidence suggests a role of PRL in the early embryonic development regarding pluripotency and nervous system development. Thus, PRL could be a crucial regulator in oocyte preimplantation and maturation as well as during diapause, a reversible state of blastocyst development arrest that shares metabolic, transcriptomic, and proteomic similarities with pluripotent stem cells in the naïve state. Thus, we analyzed the role of the hormone during those processes, which involve the regulation of its receptor and several signaling cascades (Jak/Mapk, Jak/Stat, and PI3k/Akt), resulting in either a plethora of physiological actions or their dysregulation, a factor in developmental disorders. Finally, we propose models to improve the knowledge on PRL function during early development.

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Preimplantation development in ungulates: a ‘ménage à quatre’ scenario

2020

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In ungulates, early embryonic development differs dramatically from that of mice and humans and is characterized by an extended period of pre- and peri-implantation development in utero. After hatching from the zona pellucida, the ungulate blastocyst will stay free in the uterus for many days before implanting within the uterine wall. During this protracted peri-implantation period, an intimate dialog between the embryo and the uterus is established through a complex series of paracrine signals. The blastocyst elongates, leading to extreme growth of extra-embryonic tissues, and at the same time, the inner cell mass moves up into the trophoblast and evolves into the embryonic disc, which is directly exposed to molecules present in the uterine fluids. In the peri-implantation period, uterine glands secrete a wide range of molecules, including enzymes, growth factors, adhesion proteins, cytokines, hormones, and nutrients like amino and fatty acids, which are collectively referred to as histotroph. The identification, role, and effects of these secretions on the biology of the conceptus are still being described; however, the studies that have been conducted to date have demonstrated that histotroph is essential for embryonic development and serves a critical function during the pre- and peri implantation periods. Here, we present an overview of current knowledge on the molecular dialogue among embryonic, extraembryonic, and maternal tissues prior to implantation. Taken together, the body of work described here demonstrates the extent to which this dialog enables the coordination of the development of the conceptus with respect to the establishment of embryonic and extra-embryonic tissues as well as in preparation for implantation.

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Profiles of maternal origin factors during transition from embryonic diapause to implantation in roe deer

Cited by 3 publications

References 33 publications

Endometrial extracellular matrix components do not change over the course of embryonic diapause and reactivation in the roe deer (Capreolus capreolus)

Endometrial extracellular matrix components do not change over the course of embryonic diapause and reactivation in the roe deer (Capreolus capreolus)

Prolactin from Pluripotency to Central Nervous System Development

Preimplantation development in ungulates: a ‘ménage à quatre’ scenario

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