Profiles of plasma estrogens, progesterone and their metabolites after oral or vaginal administration of estradiol or progesterone

Nahoul, K; Dehennin, L.; Jondet, M.; Roger, M

doi:10.1016/0378-5122(93)90064-o

Cited by 125 publications

(56 citation statements)

References 46 publications

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“…In Donor Egg IVF recipients, exogenous progesterone is used for reproducing the endometrial luteal phase-transformative changes [3]. Available progesterone preparations include oral-, vaginal-, oil-based intramuscular (IM) formulations and now aqueous subcutaneous (SC) Progesterone [4][5][6][7][8]. Oral preparations, however, are of limited use in fertility management because of poor bioavailability [7].…”

Section: Discussionmentioning

confidence: 99%

Has ART Finally Got a Patient-Friendly Progesterone?

Allahbadia

2015

J Obstet Gynecol India

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Section: Discussionmentioning

confidence: 99%

Has ART Finally Got a Patient-Friendly Progesterone?

Allahbadia

2015

J Obstet Gynecol India

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“…Oral or topical hormone medications with estrogens or gestagens were terminated at least 5 days before blood was taken [14][15][16]. Women with hormonal implants were excluded.…”

Section: Methodsmentioning

confidence: 99%

A Significant Correlation between Melatonin Deficiency and Endometrial Cancer

Grin

Grünberger

1998

Gynecol Obstet Invest

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Endometrial cancer is the most common pelvic genital cancer in women. Its incidence is increasing. Unlike the successful screening method for cervical cancer, there is no such equivalent procedure for the early diagnosis of endometrial cancer. Screening procedures currently being tested are too insensitive and nonspecific while diagnostics are either too complex or invasive. In Austria, a multicenter study was begun to search for parameters appropriate for a screening program. 138 women were selected based on anamnestic, serologic and cytologic risk factors. 68 women were diagnosed with endometrial cancer, 70 patients had abnormal bleeding. There were no significant differences in age and menopausal status. Secondary diseases including diabetes mellitus, hypertonia and adipositas were evenly distributed in both groups. In addition to the routine hormone analyses, we tested the patients’ plasma for differences in melatonin levels. We found a significant correlation (p < 0.001) between melatonin plasma levels and the presence of endometrial cancer. The mean plasma melatonin value was 6.1 pg/ml in the cancer-positive group and 33.2 pg/ml in the cancer-negative control group resulting in a 6-fold difference between the two groups. We conclude that decreasing melatonin plasma levels may be an indicator of endometrial cancer and that this may therefore be used as a reliable screening parameter.

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“…Reduction of the particle size of progesterone (micronization) enhances bioavailability. However, the micronized form did not provide adequate concentrations throughout the day [4], and the absorption is still erratic [5]. The advantages of the transvaginal route are lack of side effects such as local pain, avoidance of first-pass hepatic metabolism, rapid absorption, high bioavailability and local endometrial effect (first-pass uterine effect) [1,6,7].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Natural Progesterone Vaginal Suppository

Corleta

Capp

Ferreira

2004

Gynecol Obstet Invest

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Natural and synthetic progesterone have been used to treat luteal insufficiency, premenstrual syndrome, and in infertile patients. The transvaginal route has advantages, such as lack of local pain, avoidance of first-pass hepatic metabolism, rapid absorption, high bioavailability and local endometrial effect. The aim of this study was to evaluate the pharmacokinetic of natural progesterone administered as vaginal suppositories of 25, 50 or 100 mg. Thirty-five healthy ovulating patients, 31.54 ± 1.29 (mean ± SEM) years old, in the follicular phase of the menstrual cycle (between days 7 and 10) participated in the study. They were separated in three groups and received vaginal suppositories containing either 25, 50 or 100 mg of natural progesterone. Progesterone serum concentration reached maximal levels within 2 or 3 h after the administration and was similar for the three groups (7.27 ± 2.8 ng/ml; 8.84 ± 3.14 ng/ml; 9.82 ± 9.8 ng/ml, respectively). This study demonstrated that vaginally administered progesterone could reach levels that are similar to those obtained in ovulatory and luteal phases. The progesterone regimen for adequate endometrial protection and in vitro fertilization (IVF) programs still remains to be studied.

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Profiles of plasma estrogens, progesterone and their metabolites after oral or vaginal administration of estradiol or progesterone

Cited by 125 publications

References 46 publications

Has ART Finally Got a Patient-Friendly Progesterone?

Has ART Finally Got a Patient-Friendly Progesterone?

A Significant Correlation between Melatonin Deficiency and Endometrial Cancer

Pharmacokinetics of Natural Progesterone Vaginal Suppository

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