Abstract-The present study aimed to explore the factors responsible for declining students' interest towards chemistry. In this casual comparative study, the researchers collected data, through a questionnaire, from 600 science students of different secondary schools of government, semi-government, and private sectors of Lahore, Pakistan. The data analysis included mean, standard deviation (SD), percentages, correlation, t-test, and ANOVA. The results showed that students had less interest in chemistry, and the problem is more pronounced in 10 th grade students. The most prominent area of students' interest was chemistry experiments. The students in public schools were more interested in chemistry courses as compared to their peers enrolled in private schools. Moreover, the researchers found that older students were less interested in chemistry courses as compared to younger students. Among major factors, Personal Traits and Choices showed distinct role in developing students' interest towards chemistry, while Professional Scope and Role of Teacher declined students' interest. However, awareness and interest about The Professional Scope of Chemistry courses may be developed through seminars and career counselling. Also, teachers should have trainings in teaching chemistry courses to develop students' interest.Index Terms-Declining interest in chemistry, personal traits and choices, professional scope, role of teacher.