Profilin-mediated food-induced allergic reactions are associated with oral epithelial remodeling

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Section: Discussionmentioning

confidence: 99%

Persistent regulatory T‐cell response 2 years after 3 years of grass tablet SLIT: Links to reduced eosinophil counts, sIgE levels, and clinical benefit

Varona

Ramos

Escribese

et al. 2018

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“…The protocol was approved by the Committees of Research and Ethics from the participant Hospitals. These patients had been deeply studied for oral mucosa remodeling in a previous study . From these, six subjects were nonallergic and used as controls.…”

Section: Methodsmentioning

confidence: 99%

“…Profilin has proved to be a clinically relevant aeroallergen able to induce strong T‐cell proliferation . Recently, it has been proved that evolution toward severity in the profilin food allergy model is associated with a progressive rise in effector cell sensitivity, immune cells infiltration in the epithelia, and structural remodeling of the oral mucosa . This provides evidence that oral mucosa may play a key role in both food allergic reactions and respiratory‐to‐food allergy evolution.…”

Section: Introductionmentioning

confidence: 99%

Multi‐omics analysis points to altered platelet functions in severe food‐associated respiratory allergy

Obeso

Mera-Berriatua

Rodríguez-Coira

et al. 2018

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115

“…As endogenous profilins are involved in complex networks of molecular interactions, external profilins might interfere with their proper functions. Exogenous profilins might gain access into the system in individuals with impaired epithelial barrier integrity . Exogenous profilins from pathogens are also able to trigger innate immune receptors as was shown for the soluble Toxoplasma gondii profilin that binds to and induces signaling through the murine TLR11 and TLR12 …”

Section: Functional Biology Of Proteins Present In Seeds and Peanutsmentioning

confidence: 96%

The functional biology of peanut allergens and possible links to their allergenicity

Ozias‐Akins

Breiteneder

2019

Peanut is one of the most common food triggers of fatal anaphylaxis worldwide although peanut allergy affects only 1%‐2% of the general population. Peanuts are the source of highly potent allergenic proteins. It is emerging that the allergenicity of certain proteins is linked to their biological function. Peanut is an unusual crop in that it flowers aboveground but produces its seed‐containing pods underground. This so‐called geocarpic fruiting habit exposes pods and seeds during their development to soilborne pathogens and pests. Pest damage can also open routes of entry for opportunistic fungi such as Aspergillus . Although seed proteins have primary functions in nutrient reservoirs, lipid storage bodies, or the cytoskeleton, they have also evolved to act as part of the plant's defense system to enhance fitness and survival of the species. When interacting with pathogens or pests, these proteins modify and damage cells' membranes, interact with immune receptors, and modulate signaling pathways. Moreover, following exposure, the immune system of predisposed individuals reacts to these proteins with the production of specific IgE. This review explores the evolutionary biology of peanut and its seed proteins and highlights possible links between the proteins' biological function and their allergenicity.