Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons

Kullmann, Jan A.; Neumeyer, Alexander; Gurniak, Christine B.; Friauf, Eckhard; Witke, Walter; Rust, Marco B.

doi:10.1038/embor.2011.211

Cited by 33 publications

(39 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…57 Pfn1 ablation in brain inhibits radial migration of cerebellar granular neurons and causes cerebellar hypoplasia in mouse. 58 All of these studies point to a general pro-migratory function of Pfn1.…”

Section: Context-specific Effect Of Pfn1 In Cell Motilitymentioning

confidence: 99%

Molecular insights on context-specific role of profilin-1 in cell migration

Ding

Bae

Roy

2012

Cell Adhesion & Migration

View full text Add to dashboard Cite

Section: Context-specific Effect Of Pfn1 In Cell Motilitymentioning

confidence: 99%

Molecular insights on context-specific role of profilin-1 in cell migration

Ding

Bae

Roy

2012

Cell Adhesion & Migration

View full text Add to dashboard Cite

“…We found no change in the expression of Shh , considered to be the main driver of granule cell proliferation; however, given the lack of changes in cell proliferation, this is not surprising. Additional factors known to be involved in granule cell-Bergman glia interactions, including profilin1 [47] , cell adhesion molecule L1 (L1-CAM; [48] ), and α-dystroglycan [48] should be examined in future studies.…”

Section: The Effect Of Iugr On Molecular Factors That Regulate Granulmentioning

confidence: 99%

Intrauterine Growth Restriction Alters the Postnatal Development of the Rat Cerebellum

et al. 2017

View full text Add to dashboard Cite

Intrauterine growth restriction (IUGR) is a major cause of antenatal brain injury. We aimed to characterize cerebellar deficits following IUGR and to investigate the potential underlying cellular and molecular mechanisms. At embryonic day 18, pregnant rats underwent either sham surgery (controls; n = 23) or bilateral uterine vessel ligation to restrict blood flow to fetuses (IUGR; n = 20). Offspring were collected at postnatal day 2 (P2), P7, and P35. Body weights were reduced at P2, P7, and P35 in IUGR offspring (p < 0.05) compared with controls. At P7, the width of the external granule layer (EGL) was 30% greater in IUGR than control rats (p < 0.05); there was no difference in the width of the proliferative zone or in the density of Ki67-positive cells in the EGL. Bergmann glia were disorganized at P7 and P35 in IUGR pups, and by P35, there was a 10% decrease in Bergmann glial fiber density (p < 0.05) compared with controls. At P7, trophoblast antigen-2 (Trop2) mRNA and protein levels in the cerebellum were decreased by 88 and 40%, respectively, and astrotactin 1 mRNA levels were increased by 20% in the IUGR rats (p < 0.05) compared with controls; there was no difference in ASTN1 protein. The expressions of other factors known to regulate cerebellar development (astrotactin 2, brain-derived neurotrophic factor, erb-b2 receptor tyrosine kinase 4, neuregulin 1, sonic hedgehog and somatostatin) were not different between IUGR and control rats at P7 or P35. These data suggest that damage to the migratory scaffold (Bergmann glial fibers) and alterations in the genes that influence migration (Trop2 and Astn1) may underlie the deficits in postnatal cerebellar development following IUGR.

show abstract

“…37 Nestin-cre mediated deletion occurs in all brain cells and starts around embryonic day 10.5, at the onset of brain development. Mutant mice are viable and show a cerebellar hypoplasia, aberrant organization of cerebellar cortex layers, and ectopic cerebellar granule neurons (CGN).…”

Section: Profilin1 Is Important For Glial Cell Binding and Radial Migmentioning

confidence: 99%

Role of the actin-binding protein profilin1 in radial migration and glial cell adhesion of granule neurons in the cerebellum

Rust

Kullmann

Witke

2012

Cell Adhesion & Migration

Self Cite

View full text Add to dashboard Cite

Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons

Cited by 33 publications

References 28 publications

Molecular insights on context-specific role of profilin-1 in cell migration

Molecular insights on context-specific role of profilin-1 in cell migration

Intrauterine Growth Restriction Alters the Postnatal Development of the Rat Cerebellum

Role of the actin-binding protein profilin1 in radial migration and glial cell adhesion of granule neurons in the cerebellum

Contact Info

Product

Resources

About