This paper is about women entrepreneurs in Macedonia, conditions for female entrepreneurship, perspectives for development and an array of problems that women entrepreneurs are facing. In order to gain a better picture of current motives, problems and perspectives of Macedonian women in entrepreneurship, a survey was conducted during the period of December 2011 -March 2012, to complement secondary sources. Respondents were asked about motives for starting a business, the size of the business they run, revenues, their family status, management problems, and necessary capabilities as perceived by them. We used Global Entrepreneurship Monitor (GEM) reports to compare the indicators of entrepreneurial activity between Republic of Macedonia and other countries in the region.