2019
DOI: 10.1111/xen.12567
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Profiling natural serum antibodies of non‐human primates with a carbohydrate antigen microarray

Abstract: Background: Engineering of α-Galactosyltransferase gene-knockout pigs circumvented hyperacute rejection of pig organs after xenotransplantation in non-human primates. Overcoming this hurdle revealed the importance of non-α-Gal carbohydrate antigens in the immunobiology of acute humoral xenograft rejection. Methods: This study analyzed serum from seven naïve cynomolgus monkeys (blood type O/B/AB = 3/2/2) for the intensity of natural IgM and IgG signals using carbohydrate antigen microarray, which included histo… Show more

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Cited by 5 publications
(9 citation statements)
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“…The details of signal intensities are shown in S1 Table . The distribution of anti-carbohydrate antibody signal intensity in the sera was mostly similar to that of naïve sera in the previous report [ 18 ], but blood group A antigens (BG-A5-16, and BG-A-19) were listed in the posttransplant IgM and IgG repertoires with a wide distribution ( Fig 1 ).…”
Section: Resultssupporting
confidence: 81%
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“…The details of signal intensities are shown in S1 Table . The distribution of anti-carbohydrate antibody signal intensity in the sera was mostly similar to that of naïve sera in the previous report [ 18 ], but blood group A antigens (BG-A5-16, and BG-A-19) were listed in the posttransplant IgM and IgG repertoires with a wide distribution ( Fig 1 ).…”
Section: Resultssupporting
confidence: 81%
“…We have previously performed a detailed analysis for natural IgM and IgG antibody levels of naïve cynomolgus macaques ( Macaca fascicularis ) of Mauritian origin [ 18 ]. Five male monkeys with a median age of 5.3 years (range: 4.4–5.8) and a median weight of 5.0 kg (4.4–7.6) with blood type O ( n = 2), B ( n = 2), and AB ( n = 1) were recipients of adult porcine islet xenografts.…”
Section: Methodsmentioning
confidence: 99%
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