Profiling of benzimidazoles and related metabolites in pig serum based on SiO2@NiO solid-phase extraction combined precursor ion scan with high resolution orbitrap mass spectrometry

Zheng, Feng; Xiao, Hua-Ming; Zhu, Quan-Fei; Yu, Quan; Feng, Yun

doi:10.1016/j.foodchem.2019.01.071

Cited by 20 publications

(2 citation statements)

References 18 publications

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“…They can effectively prevent and cure a variety of crop diseases caused by fungi and are widely used in food animals (including pigs, horses, cattle, and sheep). Excessive or illegal use of benzimidazole drugs can lead to the accumulation of benzimidazole and its metabolites in animals, which can threaten human health through the food chain, and thus cause human adverse reactions such as diarrhea, anemia, and necrotizing lymphadenopathy [2][3][4][5]. Studies have shown that benzimidazole drugs and their metabolites can be teratogenic and mutagenic.…”

Section: Introductionmentioning

confidence: 99%

Determination of benzimidazole pesticide residues in soil by ultrasound‐assisted supramolecular solvent microextraction

Yang

Guan

et al. 2023

Separation Science Plus

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The objective of this study was to develop a simple, rapid, and efficient pretreatment method using a supramolecular solvent as the extractant combined with high‐performance liquid chromatography‐ultraviolet to detect benzimidazole residues in environmental soil. The supramolecular solvent was composed of long‐chain alcohols, tetrahydrofuran, and water in proportion, showing excellent solubility and polarity range, so a supramolecular solvent microextraction method was established. The optimum method was identified by optimizing the types of long‐chain alcohols, the alcohol/tetrahydrofuran ratio, the pH, the amount of extractant, and the extraction time. The detection limits were 12.1–39.9 μg/kg with a relative standard deviation between 1.2% and 3.2% (n = 6). The recoveries ranged between 56.6% and 86.1%, and the linear relationship was good. The correlation coefficient (r2) was 0.9843 ‐ 0.9998. This method was then used to measure five benzimidazoles (thiabendazole, albendazole sulfone, ophendazole, albendazole, and fendazole) in soil samples.

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Section: Introductionmentioning

confidence: 99%

Determination of benzimidazole pesticide residues in soil by ultrasound‐assisted supramolecular solvent microextraction

Yang

Guan

et al. 2023

Separation Science Plus

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“…Авторами [16] виявлено, що саме бензімідазоли з гетероциклічними замісниками в 2 положенні демонструють найкращу антипаразитарну активність. Для покращення розуміння дії препаратів обговорюваної серії досліджується їх метаболізм в організмах свійських тварин [17]. Останні біологічно-орієнтовані роботи продемонстрували високу активність похідних бензімі-Новітні 2-тіазол-5-іл-бензімідазоли: синтез та визначення їх потенціалу ... дазолу щодо ферменту PDE10A [18][19], що обумовило високий інтерес до них як до ліків ще й від захворювань ЦНС.…”

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New 2-thiazol-5-yl-benzimidazoles: synthesis and determining of their potential as chemosensor reagents for polyvalent metal ions

Tarasenko,

Chumak,

Kolomoitsev

et al. 2022

Chemical Series

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Thiabendazole and its analogues are widely used and reasonably well studied in terms of their biological activity, while their potential as chemosensory compounds with optical detection and sensitivity to metal ions remains unexplored. On the other hand, the introduction of a thiazole ring into the heteroaromatic system of benzimidazole significantly expands the directions of practical application of benzimidazole derivatives. Thus, one of the important structural features of the benzimidazole-thiazole system is the presence of a chelate cavity. It is a potential center of complexation with metal ions, which, with their bright fluorescence, create additional opportunities for their use as luminescent probes and chemosensors. Considering the affinity of the sulfur atom for polyvalent heavy metals, sensors based on these compounds can be used in medically and environmentally oriented analysis of toxic metal compounds. In this publication, we focus on the synthesis of various 2- and 4-substituted 2-thiazol-5-yl-benzimidazoles, as well as the determination of their spectral-fluorescence properties. Therefore, we started from 2,4-dihalogen 5-formyl thiazoles, the methods of synthesis of which are well known. Their modification in 2nd position we have described in previous works. To obtain the target products, the Weidenhagen method was chosen, which consists in the reaction of o-phenylenediamine with an aromatic or aliphatic aldehyde under oxidation conditions. For creating such conditions copper acetate was used. The possibility of coordination of metal ions by the obtained compounds was established using electronic absorption and fluorescence spectroscopy. It was found that these compounds selectively form complexes with Cd2+ and Mg2+ ions. Our qualitative studies allow us to make conclusion that the benzimidazole-thiazole fragment is a promising coordination site for metal ions, which can be used in the design of fluorescent probes for the determination of Cd2+ and Mg2+ ions.

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Simultaneous detection of thiabendazole and carbendazim in foods based on two-color upconversion and magnetic separation nanoparticles fluorescence immunoassay

Wang

Zhu

Zhao

et al. 2021

Eur Food Res Technol

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Profiling of benzimidazoles and related metabolites in pig serum based on SiO2@NiO solid-phase extraction combined precursor ion scan with high resolution orbitrap mass spectrometry

Cited by 20 publications

References 18 publications

Determination of benzimidazole pesticide residues in soil by ultrasound‐assisted supramolecular solvent microextraction

Determination of benzimidazole pesticide residues in soil by ultrasound‐assisted supramolecular solvent microextraction

New 2-thiazol-5-yl-benzimidazoles: synthesis and determining of their potential as chemosensor reagents for polyvalent metal ions

Simultaneous detection of thiabendazole and carbendazim in foods based on two-color upconversion and magnetic separation nanoparticles fluorescence immunoassay

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