Profiling of compounds and degradation products from the postharvest treatment of pears and apples by ultra-high pressure liquid chromatography quadrupole-time-of-flight mass spectrometry

Picó, Yolanda; Farré, Marinel.la; Segarra, Ramón; Barceló, Damià

doi:10.1016/j.talanta.2009.11.070

Cited by 42 publications

(15 citation statements)

References 30 publications

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“…During MFE the software annotates the detected ions to create molecular features (MF). According to the known degradation and detoxification pathways of imazalil Gilbert-López et al 2007, Picó et al 2010, Thurman et al 2005) the intermediates and by-products still possess the chlorine containing residue, therefore searching for chlorinated molecules may give a hint to find imazalil related compounds.…”

Section: Data Mining Strategy: Seeking For Chlorine Containing Metabomentioning

confidence: 99%

“…Previous studies described the existence of a degradation product of IMA arising from a -CH 3 loss (i.e., α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol; IMA-M; C 11 H 10 N 2 OCl 2 +H + ; m/z 257.0248) eluting earlier on RP columns than IMA does due to its more hydrophilic properties Gilbert-López et al, 2007, Picó et al, 2010, Thurman et al 2005.…”

Section: Metabolite Studymentioning

confidence: 99%

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Follow-up of the fate of imazalil from post-harvest lemon surface treatment to a baking experiment

Vass

Korpics

Dernovics

2015

Food Additives & Contaminants: Part A

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Imazalil is one of the most widespread fungicides used for the post-harvest treatment of citrus species. The separate use of peel during food preparation and processing may hitherto concentrate most of the imazalil into food products, where specific maximum residue limits hardly exist for this fungicide. In order to monitor comprehensively the path of imazalil, our study covered the monitoring of the efficiency of several washing treatments, the comparison of operative and related sample preparation methods for the lemon samples, the validation of a sample preparation technique for a fatty cake matrix, the preparation of a model cake sample made separately either with imazalil containing lemon peel or with imazalil spiking, the monitoring of imazalil degradation into α-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol because of the baking process, and finally the mass balance of imazalil throughout the washing experiments and the baking process. Quantification of imazalil was carried out with an LC-ESI-MS/MS set-up, while LC-QTOF was used for the monitoring of imazalil degradation. Concerning the washing, none of the addressed five washing protocols could remove more than 30% of imazalil from the surface of the lemon samples. The study revealed a significant difference between the extraction efficiency of imazalil by the EN 15662:2008 and AOAC 2007.1 methods, with the advantage of the former. The use of the model cake sample helped to validate a modified version of the EN 15662:2008 method that included a freeze-out step to efficiently recover imazalil (>90%) from the fatty cake matrix. The degradation of imazalil during the baking process was significantly higher when this analyte was spiked into the cake matrix than in the case of preparing the cake with imazalil-containing lemon peel (52% vs. 22%). This observation calls the attention to the careful evaluation of pesticide stability data that are based on solution spiking experiments.

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Section: Data Mining Strategy: Seeking For Chlorine Containing Metabomentioning

confidence: 99%

Section: Metabolite Studymentioning

confidence: 99%

Follow-up of the fate of imazalil from post-harvest lemon surface treatment to a baking experiment

Vass

Korpics

Dernovics

2015

Food Additives & Contaminants: Part A

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“…Over the last few years, in many papers UHPLC fingerprints of herbal products were developed rather than the conventional HPLC approach [100][101][102][103][104][105][106][107][108][109][110][111][112]. Comparative studies between HPLC and UHPLC analyses on Hoodia, Cocoa, and Niu Huang Jie Du Pill samples reported a decreased analysis time by a factor up to eight without loss of information [102,111,112].…”

Section: Ultra-high Performance Liquid Chromatographymentioning

confidence: 99%

Chromatographic separation techniques and data handling methods for herbal fingerprints: A review

Tistaert

Dejaegher

Heyden

2011

Analytica Chimica Acta

324

275

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“…Except for astaxanthin, there are still some other active ingredients in Haematococcus pluvialis. Owing to their difficult separation and purification, few active ingredients have been obtained from Haematococcus pluvialis.The nitrification mechanism of ethoxyquinoline (EQ), photolysis of 8-nitro-EQ, and the antioxidant function of EQ in food additives have been studied [8][9][10][11][12], and the mass spectrometry data of some EQ metabolites from the post-harvest treatment of pears and apples have been reported [13]. However, no reports on the EQ-dimer (1) and 8-nitro-EQ (2) from Haematococcus pluvialis have been found in previous references.…”

mentioning

confidence: 99%

“…The molecular structures of 1 and 2 were deduced by 1 H NMR, 13 C NMR, gHSQC, and gHMBC. For the detailed NMR assignments of 1 and 2, see Table 1.…”

mentioning

confidence: 99%

Two Ethoxyquinoline Metabolites from the Alga Heamatococcus pluvialis

Hong

Zhu

et al. 2014

Chem Nat Compd

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Haematococcus pluvialis has received considerable scientific and biotechnological attention in recent years as a rich source of the natural antioxidant astaxanthin [1,2]. The correlative researches involved in Haematococcus pluvialis have focused mainly on the extraction, separation, and purification of the active ingredient, astaxanthin [3][4][5], as well as the application of astaxanthin in human health [6,7]. Except for astaxanthin, there are still some other active ingredients in Haematococcus pluvialis. Owing to their difficult separation and purification, few active ingredients have been obtained from Haematococcus pluvialis.The nitrification mechanism of ethoxyquinoline (EQ), photolysis of 8-nitro-EQ, and the antioxidant function of EQ in food additives have been studied [8][9][10][11][12], and the mass spectrometry data of some EQ metabolites from the post-harvest treatment of pears and apples have been reported [13]. However, no reports on the EQ-dimer (1) and 8-nitro-EQ (2) from Haematococcus pluvialis have been found in previous references.In our previous work, the extraction, separation, and purification of astaxanthin [14] and stigmasterol [15] from Haematococcus pluvialis have been reported. In this work, two EQ oxidation metabolites 1 and 2 from Haematococcus pluvialis were separated and purified for the first time, and their molecular structures were confirmed by systemic spectroscopy characterization.

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Profiling of compounds and degradation products from the postharvest treatment of pears and apples by ultra-high pressure liquid chromatography quadrupole-time-of-flight mass spectrometry

Cited by 42 publications

References 30 publications

Follow-up of the fate of imazalil from post-harvest lemon surface treatment to a baking experiment

Follow-up of the fate of imazalil from post-harvest lemon surface treatment to a baking experiment

Chromatographic separation techniques and data handling methods for herbal fingerprints: A review

Two Ethoxyquinoline Metabolites from the Alga Heamatococcus pluvialis

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