Profiling of gut microbial dysbiosis in adults with myeloid leukemia

Yu, Dandan; Yu, Xinhua; Ye, Aifang; Xu, Chi; Li, Xiaolong; Wang, Geng; Zhu, Li

doi:10.1002/2211-5463.13193

Cited by 22 publications

(16 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, we further performed FMT in AML mice and found that AML-FMT aggravated the progression of AML compared with that in Con-FMT mice. A recent study by Yu et al 33 reported that the bacterial diversity was increased and no depletion of Faecalibacterium was found in AML, which is different from our results. These differences may be due to the regional and gender diversities which have been reported by other studies 34 – 37 .…”

Section: Discussioncontrasting

confidence: 99%

Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

et al. 2022

View full text Add to dashboard Cite

The gut microbiota has been linked to many cancers, yet its role in acute myeloid leukaemia (AML) progression remains unclear. Here, we show decreased diversity in the gut microbiota of AML patients or murine models. Gut microbiota dysbiosis induced by antibiotic treatment accelerates murine AML progression while faecal microbiota transplantation reverses this process. Butyrate produced by the gut microbiota (especially Faecalibacterium) significantly decreases in faeces of AML patients, while gavage with butyrate or Faecalibacterium postpones murine AML progression. Furthermore, we find the intestinal barrier is damaged in mice with AML, which accelerates lipopolysaccharide (LPS) leakage into the blood. The increased LPS exacerbates leukaemia progression in vitro and in vivo. Butyrate can repair intestinal barrier damage and inhibit LPS absorption in AML mice. Collectively, we demonstrate that the gut microbiota promotes AML progression in a metabolite-dependent manner and that targeting the gut microbiota might provide a therapeutic option for AML.

show abstract

Section: Discussioncontrasting

confidence: 99%

Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Ji et al [ 31 ] found significant enrichment of Clostridium_sensu_stricto_1 in a model of necrotic enterocolitis in neonatal mice. It was also found to be significantly enriched in IBS syndrome [ 32 ] and leukemia [ 33 ]. This is the first report of Clostridium_sensu_stricto_1 in cholestasis.…”

Section: Discussionmentioning

confidence: 99%

The difference of gut microbiome in different biliary diseases in infant before operation and the changes after operation

et al. 2022

View full text Add to dashboard Cite

Background Evidence supports an association between cholestatic liver disease and changes in microbiome composition. Nevertheless, the identification of this special type of biliary atresia from non-biliary atresia cholestasis is still a major clinical difficulty. The purpose of this study is to compare the differences in the composition of gut microbiome between infants with biliary atresia and infant with non-biliary atrestic cholestasis, to find new ways to identify and diagnose these two diseases early, to understand the influence of the presence or absence of bile on the composition of the gut microbiome in infants with cholestasis. Methods Using 16S rDNA gene sequencing technology to analyze the intestinal flora of the participants. Results In terms of diversity, there is an obvious structural separation in the intestinal microbiota of the BA group and the CD group, and this structural separation also exists in the comparison between the two groups before surgery. Taxonomic analysis demonstrated that the two groups showed an increase in Proteobacteria and Firmicutes before surgery, and the relative abundance of potential pathogens such as Shigella, Streptococcus, Klebsiella, etc. increased, potential probiotics such as Bifidobacteria and Lactobacillus decreased, but the relative abundance of each genus was different between groups. It was found that Enterococcus, Ralstonia, Nitriliruptoraceae, etc. were differentially enriched in the BA group, the CD group are mainly enriched in Veillonella, Clostridium_sensu_stricto_1 and Lactobacillus. Functional analysis of the groups showed that the BA group mainly focused on the processes of energy release processes, and the CD group mainly focused on the biosynthesis of amino-acids to consume energy. Conclusions The composition of intestinal flora is different between biliary atresia and non-biliary atretic cholestasis. Enterococcus, Ralstonia, etc. may become biomarkers for the identification and diagnosis of both.

show abstract

“…Recently, Yu and co-authors [75] observed a higher relative abundance of Actinobacteria, Acidobacteria, and Chloroflexi in the gut microbiota of myeloid leukemia compared to healthy controls; this observation confirms an alteration of the microbiota in tumor conditions. This enrichment is in line with our experimental findings, not only about Chloroflexi, but also regarding the presence of Actinobacteria in CRC biopsies (Fig.…”

Section: Discussionmentioning

confidence: 58%

Preliminary Analysis of the Presence of Bacterial Azurin Coding Gene in CRC Patients and Correlation with the Microbiota Composition

Iozzo¹,

Vitali²,

Chiellini³

et al. 2022

Front. Biosci. (Landmark Ed)

View full text Add to dashboard Cite

Background: Azurin, a bacterial cupredoxin firstly isolated from the bacterium Pseudomonas aeruginosa, is considered a potential alternative therapeutic tool against different types of cancer. Aims: In this work we have explored the relationship possibly existing between azurin and colorectal cancer (CRC), in light of the evidence that microbial imbalance can lead to CRC progression. Methodology/Results: To this aim, the presence of azurin coding gene in the DNA extracted from saliva, stool, and biopsy samples of 10 CRC patients and 10 healthy controls was evaluated by real-time PCR using primers specifically designed to target the azurin coding gene from different bacterial groups. The correlation of the previously obtained microbiota data with real-time PCR results evidenced a "preferential" enrichment of seven bacterial groups in some samples than in others, even though no statistical significance was detected between controls and CRC. The subset of azurin gene-harbouring bacterial groups was representative of the entire community. Conclusions: Despite the lack of statistical significance between healthy and diseased patients, HTS data analysis highlighted a kind of "preferential" enrichment of seven bacterial groups harbouring the azurin gene in some samples than in others.

show abstract

Profiling of gut microbial dysbiosis in adults with myeloid leukemia

Cited by 22 publications

References 29 publications

Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

The difference of gut microbiome in different biliary diseases in infant before operation and the changes after operation

Preliminary Analysis of the Presence of Bacterial Azurin Coding Gene in CRC Patients and Correlation with the Microbiota Composition

Contact Info

Product

Resources

About