2016
DOI: 10.1016/j.chroma.2016.03.019
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Profiling of urinary amino-carboxylic metabolites by in-situ heptafluorobutyl chloroformate mediated sample preparation and gas chromatography–mass spectrometry

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Cited by 49 publications
(30 citation statements)
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“…Several methods have been used for EMA analysis. LOD values for these methods were reported between 0.0044 and 0.016 mg/L for GC–MS , LC–MS , and IC . These LOD values are lower than those obtained in this study.…”
Section: Resultscontrasting
confidence: 79%
“…Several methods have been used for EMA analysis. LOD values for these methods were reported between 0.0044 and 0.016 mg/L for GC–MS , LC–MS , and IC . These LOD values are lower than those obtained in this study.…”
Section: Resultscontrasting
confidence: 79%
“…Thirteen of nineteen AAs were earlier identified and quantified in SRM 1950 by GC–MS as propyl esters of propyloxycarbonyl derivatives (Table ), and their certified and reference values are provided in the Certificate of Analysis . The remaining six AA determined in the present study were also identified earlier by GC–MS as alkoxycarbonyl derivatives in the samples of human plasma , human urine , uremia , human hair , and food samples (Table ). EI mass spectra for the derivatives of the six AA are depicted in Figure .…”
Section: Discussionsupporting
confidence: 64%
“…The identified derivatives and their GCRI values are listed in Table 3. The GCRI data T A B L E 4 Nineteen amino acids identified as alkyl esters of alkoxycarbonyl derivatives in some biological and food samples as methyl esters of methoxycarbonyl derivatives [55], as ethyl esters of ethoxycarbonyl derivatives [7,17,20,54], as propyl esters of propyloxycarbonyl derivatives [14,51], as tert-butyldimethylsilyl esters of ethoxycarbonyl derivatives [52], and as heptafluorobutyl esters of heptafluorobutyloxycarbonyl derivatives [53] Human urine…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, TCA avoids catechol group oxidation in this study. A more complicated method was elaborated by Husek et al for the determination of 56 amino acids and their conjugates, 84 organic acids, 9 biogenic amines and 4 other polar analytes in 25 µL of human urine samples [47]. They applied liquid-liquid microextraction (LLME) with a tris(3-hydroxypropyl)phosphine (THP) reducing agent and re-extraction into an isooctane with HCl prior to in-situ derivatization of amino-carboxylic metabolites with 1,1,1,2,2,3,3-heptafluorobutyl chloroformate reagent (HFBCF) and GC–MS separation.…”
Section: Sample Preparationmentioning
confidence: 99%
“…In these methods, the analytes were mainly ionized using electron ionization (EI) [47,73,74]. The chromatograms were extracted in both SIM [33,45,47,66], SRM [74] and MRM mode [67,73]. For example, GC-EI-MS supported by SPE and derivatization was applied for the quantification of DA, HVA, L-DOPA, NM, E, NE, DOPAC, VMA, 5-HT and 5-HIAA in human urine samples.…”
Section: Analytical Strategies Of Ba Determinations Based On Separmentioning
confidence: 99%