Profiling phenolic glycosides in Populus deltoides and Populus grandidentata by leaf spray ionization tandem mass spectrometry

Snyder, Dalton T.; Schilling, Marita; Hochwender, Cris G.; Kaufman, Arlen D.

doi:10.1039/c4ay02639j

Cited by 15 publications

(16 citation statements)

References 52 publications

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“…Leaf spray ionization methods have been used for performing direct analysis of steviol glycosides from stevia leaves [47], phenolic glycosides [48], rapid identification of molecular changes in tulsi (Ocimum sanctum Linn) upon ageing [49], rapid detection of urushiol allergens of toxicodendron genus [50], polyhydroxylated alkaloids in mulberry [51], and pesticide residues [52]. Leaf spray also be used for in situ chemical analysis of raw herbs [53], and distinction of coffee origin [54], phytochemicals in petals [55], and Chinese and Japanese star anise [56].…”

Section: Leaf Spraymentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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Paper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations. _________________________________________________________________________________ AbstractPaper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations.

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Section: Leaf Spraymentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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“…15 Furthermore, LS-MS has also demonstrated excellent sensitivity for the direct identification of chemical species on the surface of leaves of plants such as Populus deltoids, Populus grandidentata, 11 Hibiscus moscheutos, Hibiscus syriacus 16 and Illicium anisatum. 17 In the present work, indigenous Brazilian Hippeastrum aulicum was submitted to a classical phytochemical procedure assisted by CGC-MS, PS-MS and LS-MS. Thirty-one compounds were identified, including the new compound haemanthamine N-oxide, which was completely characterized by mono (1D) and bidimensional (2D) nuclear magnetic resonance (NMR) experiments.…”

Section: Introductionmentioning

confidence: 99%

“…The difference between paper spray and leaf spray is that the latter uses the sample itself (a plant tissue) for generating ions in gaseous phase. Ions can be generated in plant tissue without adding a solvent, 11 due to the natural juice present in fruit and vegetables. However, mass spectra with more intense signals and an improved signal/noise ratio can be obtained when a solvent is added.…”

Section: Introductionmentioning

confidence: 99%

Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb. (Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS‑MS and LS-MS)

Bessa

Andrade

Domingos

et al. 2016

J. Braz. Chem. Soc.

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Amaryllidaceae alkaloids are well-known isoquinolines which have demonstrated a wide range of biological activities such as antiviral, anticancer, acetylcholinesterase inhibition, antimalarial, among others. Mass spectrometry (MS) studies based on capillary gas chromatography (CGC), paper spray (PS), and leaf spray (LS) ionization were carried out for alkaloid investigation of the native Brazilian species Hippeastrum aulicum, along with nuclear magnetic resonance (NMR) techniques. Thirty-one alkaloids were identified including the new compound haemanthamine N-oxide. The results from PS-and LS-MS techniques were consistent with those observed in CGC-MS analysis. To the best of our knowledge, it is the first study combining NMR, CGC-MS and the ambient ionization-mass spectrometry (PS-and LS-MS) on Amaryllidaceae plants.

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“…Examples include determination of protein/peptide modification sites (e.g. phosphorylation, methylation, and glycosylation), as well as detection of phosphopeptides, identification of cross‐linked peptides, determination of glycosylated compounds, characterization of alkaloids, phospholipids and other phytochemicals in plants, analysis of physiological metabolic products, and determination of pharmaceutical residues in water …”

mentioning

confidence: 99%