Profiling Proteasome Activities in Peripheral Blood – A Novel Biomarker Approach

doi:10.33696/immunology.4.147

Cited by 2 publications

(2 citation statements)

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“…The underlying mechanism requires further investigation. However, it is appreciated that the catalytic subunits of the immunoproteasome are differentially regulated under inflammatory and stress conditions [ 21 , 47 ]. To this end, we recently demonstrated in a large population-based cohort that the activity of the catalytic subunits of the proteasome in peripheral blood cells are differentially regulated depending on sex and age and chronic inflammatory diseases [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Antiviral CD8⁺T-cell immune responses are impaired by cigarette smoke and in COPD

et al. 2023

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BackgroundVirus infections drive COPD exacerbations and progression. Anti-viral immunity centers on the activation of virus-specific CD8+T cells by viral epitopes presented on MHC class I molecules of infected cells. These epitopes are generated by the immunoproteasome, a specialized intracellular protein degradation machine, which is induced by anti-viral cytokines in infected cells.MethodsWe here analysed the effects of CS on cytokine and virus-mediated induction of the immunoproteasomein vitro,ex vivoandin vivousing RNA and Western blot analyses. CD8+T cell activation was determined in co-culture assays with CS-exposed Influenza A virus (IAV)-infected cells. Mass-spectrometry-based analysis of MHC class I-bound peptides uncovered the effects of CS on inflammatory antigen presentation in lung cells. IAV-specific CD8+T cell numbers were determined in peripheral patients’ blood using tetramer-technology.ResultsCS impaired the induction of the immunoproteasome by cytokine signaling and viral infection in lung cellsin vitro,ex vivoandin vivo. CS also altered the peptide repertoire of antigens presented on MHC class I under inflammatory conditions. Importantly, MHC class I-mediated activation of IAV-specific CD8+T cells was dampened by CS. COPD patients exhibited reduced numbers of circulating IAV-specific CD8+T cells compared to healthy controls and asthmatics.ConclusionOur data indicate that cigarette smoke interferes with MHC class I antigen generation and presentation and thereby contributes to impaired activation of CD8+T cells upon virus infection. This adds important mechanistic insight on how cigarette smoke mediates increased susceptibility of smokers and COPD patients to viral infections.

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Section: Discussionmentioning

confidence: 99%

Antiviral CD8⁺T-cell immune responses are impaired by cigarette smoke and in COPD

et al. 2023

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“…Minerals are essential for maintaining a healthy musculoskeletal system, as they are involved in muscle contraction, nerve conduction, and bone formation [19]. Low levels of minerals such as calcium, magnesium, iron, potassium, and zinc have been linked to increased risk of sarcopenia.…”

Section: Mineralsmentioning

confidence: 99%

Exploring the Potential of Treating Sarcopenia through Dietary Interventions

Srivastava,

Pandey,

Singh

et al. 2024

Journal of Food Biochemistry

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Sarcopenia, the age-related loss of muscle mass and function, is a growing concern as the global population continues to age. It is associated with physical disability, decreased quality of life, and increased risk of falls and fractures. Nutritional interventions have been suggested to be effective in the prevention and treatment of sarcopenia. According to cross-sectional studies, the prevalence of sarcopenia in people with heart failure (HF) is 38% for men and 32% for women, contributing to cardiac fragility, a lower quality of life, and an increased risk of death. A rising number of research studies have been performed to investigate the role of certain nutrients on muscle mass or function, as appropriate nutrition is crucial for muscle maintenance. The goal of this systematic review is to outline the present evidence for exercise and nutritional interventions as potential contributors to the treatment of sarcopenia and frailty (decreased muscle mass and physical function), as well as the threat of underlying cardiac metabolic comorbidity in individuals who have heart failure (HF), cancer, CVDs, and other health problems. The biochemical properties of natural foods play a crucial role in the prevention and treatment of sarcopenia. This review explores the effectiveness of nutritional interventions for the prevention and treatment of sarcopenia.

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Profiling Proteasome Activities in Peripheral Blood – A Novel Biomarker Approach

Cited by 2 publications

References 78 publications

Antiviral CD8⁺T-cell immune responses are impaired by cigarette smoke and in COPD

Antiviral CD8⁺T-cell immune responses are impaired by cigarette smoke and in COPD

Exploring the Potential of Treating Sarcopenia through Dietary Interventions

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Profiling Proteasome Activities in Peripheral Blood – A Novel Biomarker Approach

Cited by 2 publications

References 78 publications

Antiviral CD8+T-cell immune responses are impaired by cigarette smoke and in COPD

Antiviral CD8+T-cell immune responses are impaired by cigarette smoke and in COPD

Exploring the Potential of Treating Sarcopenia through Dietary Interventions

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Antiviral CD8⁺T-cell immune responses are impaired by cigarette smoke and in COPD

Antiviral CD8⁺T-cell immune responses are impaired by cigarette smoke and in COPD