Profound peripheral T-lymphocyte depletion and activation in disseminated tuberculosis

Rodrigues, Denise; Salomão, Reinaldo; Kallas, Esper G.

doi:10.1590/s1413-86702006000100012

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Cellular immune responses especially those produced by T lymphocytes play an important role in controlling the replication of Mycobacterium tuberculosis (MTB) as well as neutrophils play a role in naive immunity to MTB. Lymphopenia, neutrophilia and monocytosis are the most common hematological abnormalities in TB (8,9) . The neutrophil-lymphocyte ratio (NLR) is an inflammatory marker that can be used to estimate various clinical conditions including cancer and coronary heart disease and also shows differences based on the type of infection.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Acid-Fast Bacilli in Tuberculosis

2021

IJFMT

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Background: Tuberculosis (TB) is one of the top 10 causes of death in the world and the most common cause of death with single infectious agent. The neutrophil-lymphocyte ratio is a cheap and fast marker of inflammation that has been widely studied in TB. The aimed of this study was to investigate Neutrophillymphocyte ratio (NLR) in TB with positive Acid-Fast Bacilli (AFB) and negative AFB. Methods: This was a retrospective study that included TB patients data from the medical records in two hospitals in Palu, Indonesia. A total of 150 TB patients were involved in this study consisting with positive and negative AFB TB suspect. Neutrophil, lymphocyte and NLR data were compared with the Mann-Whitney test. Results:The study shows a significant difference of neutrophils and lymphocytes percentage between positive AFB TB patients (80 subjects, 53.3%) and negative AFB TB patients (70 subjects, 46.7%) with (p < 0.001) as well as NLR (p < 0.001). The percentage of Neutrophils was significantly higher in positive AFB TB compared to negative AFB tuberculosis (81.18 ± 8.52 vs. 55.02 ± 9.80), lymphocyte percentage were found to be significantly lower in positive AFB TB compared with negative AFB TB (12.72 ± 7.51 vs 28.69 ± 12.01). Additionally, NLR were significantly higher in positive AFB TB compared with negative AFB TB (10.20 ± 9.53 vs 2.47 ± 1.56). Conclusion: There is a significant increase in the number of neutrophils, a decrease in lymphocytes and an increase in NLR among positive AFB TB compared with negative AFB TB.

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Section: Introductionmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Acid-Fast Bacilli in Tuberculosis

2021

IJFMT

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“…предлагают использовать процент «наивных» СD4-лимфоцитов в качестве нового маркера для определения более раннего момента показаний к началу АРВТ [11]. Изме-нение фенотипа CD8-лимфоцитов (экспрессия CD38) имеет большую значимость для оценки прогрессирования ВИЧ-инфекции [6,9,10].…”

Section: Introductionunclassified

Comparative Study of “Klim-Test” Monoclonal Antibodies for Phenotyping of Peripheral Blood Cells With Monoclonals From Foreign Producers

Popova¹,

Серебровская²,

Ivanova³

et al. 2014

Med.Imm.Rus

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Bacterial dissemination in Mycobacterium tuberculosis by CD+ T-cells & proinflammatory cytokines

Davuluri,

Singh,

Chauhan

2023

Indian Journal of Medical Research

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Background & objectives: As CD4+ and CD8+ T lymphocyte numbers decline, the conventional, localized forms of tuberculosis shift to the atypical, disseminated forms. Variations in lymphocyte and immune cell expression levels affect how tuberculosis manifests in disseminated forms. Understanding the relationship between lymphocyte counts (CD4+ and CD8+) and pro-inflammatory cytokines such as tumour necrosis factor-alpha, interleukin-12 and interferon, we may therefore be able to shed light on how infections spread and suggest potential biomarkers for these immune factors. Methods: In this study, 15 guinea pigs were infected with Mycobacterium tuberculosis (M.tb) H37Rv strain and grouped into three groups of five each for further investigation. Serum samples and bronchoalveolar lavage (BAL) fluid were examined for the expression of pro-inflammatory cytokines and T-cell subsets in guinea pigs infected with pulmonary tuberculosis and disseminated tuberculosis. Results: We found that M.tb escapes macrophages due to pro-inflammatory cytokine dysregulation. Despite the protective immunity created by T-cells and cytokines, M.tb bacilli may spread to other organs due to inflammation induced by these immune components. A high number of T-cells and stimulated cytokine production are involved in triggering inflammation after necrotic tissue develops and tuberculosis spreads. Interpretation & conclusions: Our findings imply that increased bacilli in the spleen at the 8th wk of infection may be caused by the overexpression of CD4+ T-cell lymphocyte subsets and cytokines that generated inflammation during the 4th wk of infection. This is a pilot study with a small sample size and less assertive inference. Larger studies would be helpful to validate the results of the present investigation.

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Profound peripheral T-lymphocyte depletion and activation in disseminated tuberculosis

Cited by 3 publications

References 11 publications

Neutrophil Lymphocyte Ratio and Acid-Fast Bacilli in Tuberculosis

Neutrophil Lymphocyte Ratio and Acid-Fast Bacilli in Tuberculosis

Comparative Study of “Klim-Test” Monoclonal Antibodies for Phenotyping of Peripheral Blood Cells With Monoclonals From Foreign Producers

Bacterial dissemination in Mycobacterium tuberculosis by CD+ T-cells & proinflammatory cytokines

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