2020
DOI: 10.1007/s12672-020-00379-1
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Progesterone and Breast Cancer: an NCI Workshop Report

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Cited by 15 publications
(14 citation statements)
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References 67 publications
(77 reference statements)
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“…E2 and P4 in combination may also increase risk, whereby E2 induces PR expression allowing P4 to agonize the receptor and induce proliferation of mammary stem and progenitor cells, thus promoting tumor progression (Brisken et al 2015). Notably, the interaction between E2 and P4 (and ER/ PR) in mammary tumor etiology is complex and still being elucidated (Sathyamoorthy and Lange 2020). Although E2 and P4 can be tumor promoting, their administration to nulliparous rodents at concentrations high enough to differentiate the mammary gland, which mimics the effects of pregnancy, has been shown to reduce mammary tumor incidence (Sivaraman et al 1998).…”
Section: Introductionmentioning
confidence: 99%
“…E2 and P4 in combination may also increase risk, whereby E2 induces PR expression allowing P4 to agonize the receptor and induce proliferation of mammary stem and progenitor cells, thus promoting tumor progression (Brisken et al 2015). Notably, the interaction between E2 and P4 (and ER/ PR) in mammary tumor etiology is complex and still being elucidated (Sathyamoorthy and Lange 2020). Although E2 and P4 can be tumor promoting, their administration to nulliparous rodents at concentrations high enough to differentiate the mammary gland, which mimics the effects of pregnancy, has been shown to reduce mammary tumor incidence (Sivaraman et al 1998).…”
Section: Introductionmentioning
confidence: 99%
“…Many reviews have addressed in detail the different stages of the mammary gland (MG) development [42][43][44], and many others have focused in the role of progesterone (Pg) and PR in the normal and neoplastic MG [45][46][47][48][49][50][51][52][53]. Briefly, the MG develops after birth to generate a rudimentary duct tree.…”
Section: Pr and Mammary Gland Developmentmentioning
confidence: 99%
“…Over the last 20 years, the role of the microenvironment in tumorigenesis of thyroid cancer has been well-defined [ 15 ]. The components of the thyroid cancer microenvironment (stromal cells, ST, and extracellular matrix components (ECM)) surround and support cancer cells, interacting with them by direct cell-cell and cell-extracellular matrix components interaction.…”
Section: The Thyroid Cancer Microenvironmentmentioning
confidence: 99%
“…MMP-9 expression is upregulated in PTC and might be a prognostic indicator for more advanced-stage cancer [ 139 , 140 , 141 , 142 ]. The prognostic role of other components of the extracellular matrix of thyroid cancer tangentially involved in angiogenetic processes, such as macrophages and T lymphocytes, is yet to be clarified [ 15 ].…”
Section: Angiogenesis and Prognosismentioning
confidence: 99%