Progesterone and cyclic adenosine monophosphate down‐regulate CD90 in the stromal cells of human decidua. In vitro evidence and in situ findings

Vinketova, Kameliya; Karagyozov, Iliya I.; Koleva, Vesselina; Hristov, Michael; Mourdjeva, Milena; Sperandio, Markus; Oreshkova, Tsvetelina

doi:10.1111/aji.13043

Cited by 1 publication

(1 citation statement)

References 51 publications

(108 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cells maintain the growth, invasiveness, and metastatic properties of tumors [ 22 , 23 ]. Differentiation of tumor stem cells and mesenchymal stromal cells induces decrease of CD90 [ 22 , 24 , 25 ], whereas inflammatory cytokines trigger shedding of CD90 from the membrane of CD90-expressing cells [ 26 ]. In vivo , soluble CD90 (sCD90) is reported in serum, cerebral spinal fluid, wound fluid, and synovial fluid.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Soluble CD90: Potential for Diagnostic Significance in Endometriosis Patients

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background. Endometriosis is a chronic and debilitating gynecologic disorder, driven by endocrine and immune dysfunctions, which lead to poor endometrial differentiation and attenuated fertility. Escape from immune surveillance and involvement of inflammatory mechanisms appear to be factors in disease progression. Current diagnostic guidelines for endometriosis still lack an efficient biomarker. Here, we report a study on two previously unexplored factors as potential biomarkers for endometriosis. Methods. A case-control study was performed to evaluate the diagnostic potential of serum CD90 and CD83 levels in endometriosis patients (cases validated by surgical and histological examination) compared to healthy controls. Serum was collected from age-matched females and analyzed by ELISA. Results. Comparison of endometriosis patients to the control group showed significantly elevated levels of serum CD90 ( 1160 ± 856 pg/mL vs. 334 ± 228 pg/mL; ∗ ∗ ∗ ∗ p < 0.0001 ). A threshold value of 479.4 pg/mL was defined based on the control results, and the diagnostic efficiency of the test was estimated. The obtained sensitivity (70.4%), specificity (92.9%), positive predictive value (90.5%), and negative predictive value (76.5%) rated the test as one with promising diagnostic potential. In contrast, the analysis of serum CD83 levels showed comparable values in both groups, suggesting no association with patient status. Conclusion. Elevated soluble CD90 in human serum is associated with endometriosis, which suggests its putative clinical significance as a biomarker in screening and/or diagnosis of the disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of Soluble CD90: Potential for Diagnostic Significance in Endometriosis Patients

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Progesterone and cyclic adenosine monophosphate down‐regulate CD90 in the stromal cells of human decidua. In vitro evidence and in situ findings

Abstract: DSCs in early pregnancy show different levels of CD90 expression, suggesting different DSC differentiation and selective interactions with cells during decidual morphogenesis.

Cited by 1 publication

References 51 publications

Evaluation of Soluble CD90: Potential for Diagnostic Significance in Endometriosis Patients

Evaluation of Soluble CD90: Potential for Diagnostic Significance in Endometriosis Patients

Contact Info

Product

Resources

About