Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats

Tang, Hongsheng; Fang, Hua; Wang, Jun; Sayeed, Iqbal; Wang, Xiaojing; Chen, Zhengjia; Yousuf, Seema; Atif, Fahim; Stein, Donald G.

doi:10.1016/j.yhbeh.2013.06.009

Cited by 55 publications

(43 citation statements)

References 71 publications

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“…83 A significant reduction in phosphorylation of nuclear factors, which in turn stimulate downstream genes involved in the inflammatory cascade, were shown to be reduced by vitamin D treatment post-TBI. 85 In separate studies, Tang et al 86 and Cekic et al 87 demonstrated that vitamin D deficiency was associated with more adverse pathophysiological outcomes following TBI. Of note, an estimated 40% of adolescents have insufficient vitamin D. 88 Further, in a clinical sample, Hua et al 89 …”

Section: Vitamin Dmentioning

confidence: 99%

Nutrition as Medicine to Improve Outcomes in Adolescents Sustaining a Sports-related Concussion

Casazza¹,

Swanson²

2017

Exploratory Research and Hypothesis in Medicine

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Recognition and diagnosis of sports-related concussion (SRC) among adolescents has significantly increased. In, fact, among high school adolescents, SRC incidence has more than doubled from 2007 to 2014, with recent estimates at approximately 2 per 100 athletes. SRC-related research has also increased; recognition of symptoms that may prolong recovery have been examined, potential biomarkers have been scrutinized, return-to-learn and return-to-play protocols have been developed and honed. However, to date, clinicians and researchers have struggled to find effective interventions to mitigate the significant symptoms after SRC and shorten recovery times. Despite the understood role of the brain as the primary regulator of metabolism, and the well-established metabolic impairments evoked after a concussion, nutrition is often ignored as a core complement to the recovery and rehabilitation process. In this article, we will identify deficiencies and/or inadequacies in nutrients post-concussion and provide support for potential exacerbation of injury and delayed recovery due to inadequate intake of nutrients prior to sustaining an SRC. Additionally, we will discuss the effect of derangement of the metabolic cascade post-concussion, and identify key nutrients, that if supplemented immediately post-injury, could increase neuroprotection, and improve recovery outcomes. Animal and cell culture studies have provided substantial evidence for not only the interrelationship of nutrient adequacy and the adaptation in the metabolic cascade post-concussion on neuroprotection, but also key nutrients that if supplemented immediately post-injury could enhance standard of care with minimal risk.

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Section: Vitamin Dmentioning

confidence: 99%

Nutrition as Medicine to Improve Outcomes in Adolescents Sustaining a Sports-related Concussion

Casazza¹,

Swanson²

2017

Exploratory Research and Hypothesis in Medicine

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“…To control for effects following injections and/or pump implantation, all animals were injected, anesthetized, and implanted with osmotic pumps. Three behavioral metrics were evaluated at 4,6,8,11,17,24, and 28 days post-injury: a bilateral tactile adhesive removal task as a sensory assessment, and both a forelimb asymmetry task and foot placing task as motor assessments.…”

Section: Concurrent Targeted Therapy Combination: Probenecid and N-acmentioning

confidence: 99%

“…Unexpectedly, we observed first that VDH deficiency alone for 3 weeks in middle-aged male rats did not significantly reduce baseline behavioral functions or aggravate impaired cognitive outcomes during long-term functional assessment. 17 We speculate that a much longer period of chronic VDH deficiency in older animals might be needed to produce significant impairments in the recovery process as measured over long-term assessment and that species differences could also play a role.…”

mentioning

confidence: 94%

“…Importantly, we concluded that for VDH supplementation, the severity of the VDH deficiency, dosing, duration of treatment, and appropriate drug/dose combinations may not be linear, and this idea will require a more thorough study. 17 Extrapolating these pre-clinical data to patients will clearly be more complex because dietary factors, combined morbidities, sex differences, exercise, and climate, among others, may have to be taken into consideration in the planning of clinical trials with agents whose mechanistic and functional actions could be affected by any of these factors.…”

mentioning

confidence: 99%

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Combination Therapies for Traumatic Brain Injury: Retrospective Considerations

MarguliesSusan

AndersonGail

AtifFahim

et al. 2016

Journal of Neurotrauma

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Patients enrolled in clinical trials for traumatic brain injury (TBI) may present with heterogeneous features over a range of injury severity, such as diffuse axonal injury, ischemia, edema, hemorrhage, oxidative damage, mitochondrial and metabolic dysfunction, excitotoxicity, inflammation, and other pathophysiological processes. To determine whether combination therapies might be more effective than monotherapy at attenuating moderate TBI or promoting recovery, the National Institutes of Health funded six preclinical studies in adult and immature male rats to evaluate promising acute treatments alone and in combination. Each of the studies had a solid rationale for its approach based on previous research, but only one reported significant improvements in long-term outcomes across a battery of behavioral tests. Four studies had equivocal results because of a lack of sensitivity of the outcome assessments. One study demonstrated worse results with the combination in comparison with monotherapies. While specific research findings are reported elsewhere, this article provides an overview of the study designs, insights, and recommendations for future research aimed at therapy development for TBI.

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“…3 and progesterone was also observed in the prevention of glutamateinduced cell death in primary cortical neurons in vitro as well as in vivo after brain injury in rats [435][436][437] .…”

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confidence: 99%

Mapping the effects of vitamin D in multiple sclerosis

Rolf¹

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Columbus (1451Columbus ( -1506 on one of his four voyages Er zijn verrassend veel parallellen te trekken tussen onderzoek doen en een van mijn favoriete vrijetijdsbestedingen, namelijk koken. Alles begint met een inspiratie, nieuwsgierigheid en een idee. Dan volgt de planning en de uitvoering en na (lang…) wachten kun je het resultaat proeven. Het blijft altijd spannend of het gelukt is en of het wel lekker is. Als het lekker is, dan smaakt het vaak ook naar meer! Zo niet, dan moet je het recept aanpassen, of crucialer, iets heel anders verzinnen...De weg naar een goed gelukt gerecht is, althans voor mij, minstens zo belangrijk: watertandend recepten zoeken en menu's samenstellen, op zoek gaan naar de juiste producten, lekker creatief combineren en (al of niet met succes) uitproberen. Dat kon ook in de voor mij nieuwe keuken van de wetenschap, en wel in een restaurant met een excellente ambiance. Verder is de diversiteit aan smaken, waar ik bij eten zo van houd, zeker ook terug te vinden in de verschillende hoofdstukken.Of kookkunsten gewaardeerd worden is vervolgens een kwestie van smaak, maar ook van kennis. De fijnproevers zullen zich op de details storten en boeren die het niet kennen zullen het niet eten, maar voor iedereen die aan tafel schuift: hopelijk is datgene wat in dit boekje geserveerd wordt smakelijk en levert het gespreksstof op voor het natafelen! Abbreviations and glossary & G L O S S A R Y AB BR EVI ATI ONS 23General IntroductionHistorical explorers discovered new land around the world, and with every journey more details have been added to global maps. For multiple sclerosis research, explorers of the 20 th century put vitamin D on the map, and from 2008 onwards, our research team in Maastricht has tried to add more details to this area. Today, vitamin D in multiple sclerosis is still an active area of research. Many reviews concentrate on the role of vitamin D in multiple sclerosis, illustrated by clinical and immunological studies. Also in this thesis two reviews elaborate on this topic. Therefore, the introduction to this thesis is restricted to the essential players, i.e. multiple sclerosis, its immune pathogenesis, and vitamin D, followed by the outline of the thesis.Multiple sclerosis (MS) is the most common disabling neurological disease among young people. Initial symptoms generally occur in the age of 20-40 years and MS affects women 2-3 times more often compared to men [1][2] . Currently, almost 1 in 1000 people suffers from MS in the Netherlands [3] . MS is characterized by inflammation and neurodegeneration of the central nervous system (CNS; brain and spinal cord). Though, it is still a matter of debate whether it is neurodegenerative or inflammatory from onset [1,4] . Most accepted, however, is the thought that inflammatory processes lead to damage of the fatty myelin sheaths covering the neuronal axons, which normally support fast transduction of signals, and this process is called demyelination. The inflammation can be accompanied by axonal injury and over time this result...

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Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats

Cited by 55 publications

References 71 publications

Nutrition as Medicine to Improve Outcomes in Adolescents Sustaining a Sports-related Concussion

Nutrition as Medicine to Improve Outcomes in Adolescents Sustaining a Sports-related Concussion

Combination Therapies for Traumatic Brain Injury: Retrospective Considerations

Mapping the effects of vitamin D in multiple sclerosis

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