Progesterone elevation on the day of oocyte retrieval and live birth rate after <i>in vitro</i> fertilisation treatment

Fernandez, M.; Lleó, Cristina Álvarez; Mirasol, Esteban González; Serra, Maria Resta; Garrido, C.; Toledo, María Sánchez; Recover, Antonio Amezcua

doi:10.1080/01443615.2021.1983780

Cited by 7 publications

(8 citation statements)

References 25 publications

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“…Pregnancy rates were not affected; however, there were more miscarriages (25.7% versus 43.8%) and a lower live birth rate (28.0% versus 23.1%) in the P4 rise group, which is not statistically significant. 23 There was no statistically significant difference found in demographic variables and use of type of gonadotropins in this study.…”

Section: Specificity Sensitivitycontrasting

confidence: 54%

“…21 Despite this challenging possibility, there have been few studies that have sought to determine the normal distribution of P4 levels at 36 hours after an hCG trigger, or threshold P4 levels at this time point beyond which pregnancy is unlikely. [21][22][23]…”

Section: Articlementioning

confidence: 99%

“…Patients with a P4 rise (>12 ng/mL) on the day of OCR had lower pregnancy and implantation rates in this study. 20 Fernandez et al 23 performed a cohort study of 400 IVF/ICSI cycles, with a fresh embryo transfer on day 2or 3. They proposed a serum P4 level on percentile 90 as a threshold.…”

Section: Specificity Sensitivitymentioning

confidence: 99%

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The Association of Serum Progesterone Levels on Day of Oocyte Retrieval with Pregnancy Outcome

Garg

2022

EMJ Repro Health

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Aims and Objectives: To establish the level of serum progesterone (P4) on the day of oocyte retrieval beyond which it can affect the outcome of in vitro fertilisation (IVF), and to further establish the incidence of serum P4 rise in an agonist and antagonist cycle. Methods: This prospective observational cohort study was conducted from November 2020 to November 2021 at the Sarvodaya Fertility and IVF Centre, Delhi, India. For this study, the author recruited 352 couples with infertility who were treated with IVF/intracytoplasmic sperm injection-embryo transfer, of which 279 patients completed an IVF/intracytoplasmic sperm injection-embryo transfer cycle during the study period and were included in the final analysis. The standard gonadotropin-releasing hormone antagonist (fixed or variable) and long gonadotropin-releasing hormone agonist controlled ovarian stimulation protocols were used in all patients. Participants were recruited if they were undergoing controlled ovarian stimulation with all gonadotropins, recombinant follicle-stimulating hormone/urinary human menopausal gonadotropin, or recombinant luteinising hormone. The study population was sub-grouped into two groups according to their P4 level on day of oocyte retrieval (calculated according to receiver operating characteristics curve): Group A (p≤11.6 ng/dL; n=247 out of 27; 88.5%) and Group B (p>11.6 ng/dL; n=32 out of 279; 11.5%). Statistical analysis was performed with the Statistical Package for Social Sciences (SPSS) 17.0 version (IBM, New York City, New York, USA). Results: The percentage of patients with a rise in P4 on the day of oocyte retrieval were found significantly more in the antagonist protocol (13.3% [24 out of 181]) than in the agonist protocol (8.2% [8 out of 98]; p=0.04). Pregnancy rate was significantly higher in Group A (39.3% [97 out of 247]) compared with Group B (12.5% [4 out of 32]). The clinical pregnancy rate was also significantly higher in Group A (34.4% [85 out of 247]) compared with Group B (6.3% [2 out of 32]). Conclusion: Patients with higher levels of P4 (>11.6 ng/mL) were associated with lower pregnancy and clinical pregnancy rates.

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Section: Specificity Sensitivitycontrasting

confidence: 54%

Section: Articlementioning

confidence: 99%

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The Association of Serum Progesterone Levels on Day of Oocyte Retrieval with Pregnancy Outcome

Garg

2022

EMJ Repro Health

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“…( 35 ) reported that IVF fertilization rates were similar between different P levels (≤0.50 ng/ml, 0.5–1.5 ng/ml and >1.5 ng/ml), which confirmed that serum P levels did not affect IVF fertilization rates. A recent study using the 90th percentile of the distribution of serum P levels as a basis for grouping also showed that P levels had no negative effects on oocyte or embryo quality ( 36 ). Embryo implantation theory suggests a specific implantation window for embryo implantation.…”

Section: Discussionmentioning

confidence: 99%

Effect of serum progesterone levels on hCG trigger day on pregnancy outcomes in GnRH antagonist cycles

Zhang

Du²,

Wu³

et al. 2022

Front. Endocrinol.

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ObjectiveThe present study analyzed the effect of hCG trigger day progesterone (P) levels on the live birth rate (LBR) in the gonadotropin-releasing hormone (GnRH) antagonist protocol.Materials and methodsThis study was a single-center retrospective study. In vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles performed from January 2017 to December 2020 were included in the analysis. This study included people with a normal ovarian response to fresh embryo transfer of GnRH antagonist protocols. All cycles were divided into 2 groups by P level on the day of human chorionic gonadotropin (hCG) trigger, P<1.0 ng/ml and P≥1.0 ng/ml. The primary outcome measure was LBR.ResultA total of 867 cycles with P<1.0 ng/ml and 362 cycles with P≥1.0 ng/ml were included in the analysis. The clinical pregnancy rate (CPR) was higher in the P<1.0 ng/ml group than the P≥1.0 ng/ml group (44.9% vs. 37.6%, P=0.02). The early spontaneous abortion rate was comparable between the groups (14.4% vs. 14.7%, P=0.93). For live birth, the rate for the P<1.0 ng/ml group was 35.3%, which was significantly higher than the 29.0% in the P≥1.0 ng/ml group (P=0.03). After binary logistic regression analysis, the P level on the hCG trigger day (adjusted odds ratio=0.74, 95% CI=0.55-0.99, P=0.04) was an independent risk factor for LBR. For the P level on the hCG trigger day, the LBR was lower in the P≥1.0 ng/ml group compared to the P<1.0 ng/ml group.ConclusionFor normal ovarian response patients using the GnRH antagonist protocol, serum P≥1.0 ng/ml on the hCG trigger day resulted in a lower LBR than the P<1.0 ng/ml group. When P≥1.0 ng/ml, whole embryo freezing may be considered.

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“…However, to date, there are not many pieces of evidence that could suggest the predictive value of basal hormone levels in the evaluation of these patients. The most commonly used endocrinologic indicators of treatment success are follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), and progesterone (P4) levels [ 3 , 4 , 5 ], although no specific hormonal parameter for women affected by endometriosis is currently available to predict fertility prognosis.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach

Bila

Dotlić

Radjenović

et al. 2022

JPM

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The data regarding the role of progesterone (P4) in reproductive events of endometriosis patients are limited. This prospective study aimed to examine the predictive value of basal P4 serum levels for successful in vitro fertilization (IVF) in patients with primary infertility and endometriosis. The study included 73 patients divided according to endometriosis treatment (surgery vs. control—no treatment). The general data, basal hormonal status, and pregnancy rates were determined for every patient. Clinical pregnancy was achieved in 40.3% of patients, and more often in patients treated for endometriosis before IVF. The regression analysis showed that higher basal P4 serum levels were associated with achieving pregnancy through IVF. When regression was adjusted for the patient and IVF characteristics, higher basal P4 serum levels were associated with pregnancy achievement in both groups of women, along with the basal serum levels of FSH, LH, and AMH; EFI score; and stimulation protocol. The ROC analysis showed that the basal P4 serum level for successful IVF should be ≥0.7ng/mL. The basal P4 serum level cut-off for IVF success in endometriosis patients was determined for the first time. Constructed models for IVF success prediction emphasize the importance of determining the basal P4 serum levels for the personalized treatment of endometriosis-related infertility.

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Progesterone elevation on the day of oocyte retrieval and live birth rate after in vitro fertilisation treatment

Cited by 7 publications

References 25 publications

The Association of Serum Progesterone Levels on Day of Oocyte Retrieval with Pregnancy Outcome

The Association of Serum Progesterone Levels on Day of Oocyte Retrieval with Pregnancy Outcome

Effect of serum progesterone levels on hCG trigger day on pregnancy outcomes in GnRH antagonist cycles

Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach

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