Progesterone-induced blocking factor (PIBF) influences the expression of membrane progesterone receptors (mPRs) on peripheral CD4+ T lymphocyte cells in normal fertile females

Rafiee, Mitra; Rezaei, Abbas; Alipour, Razieh; Sereshki, Nasrin; Motamedi, Narges; Naseri, Mohsen

doi:10.1007/s42000-021-00291-5

Cited by 11 publications

(11 citation statements)

References 37 publications

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“…The concentrations of the progesterone hormone in the three groups are consistent with the rate of stillborns in them. It is known that the survival of the fetus and increase the stillborn rate effect by hormone decrease [38]. This concentration difference between the three groups is due to the positive effect of high estrogen in female pregnant women compared to male pregnant women [45].…”

Section: Discussionmentioning

confidence: 92%

“…In normal pregnancies, the concentration of progesterone increases gradually with the progression of the pregnancy until it reaches its peak during the third stage of pregnancy, then begins to decline before birth, and the delay in its decline before birth leads to a case of delayed delivery from its natural time. Progesterone decreasing during the three stages of pregnancy result in stillborn [38].…”

Section: Discussionmentioning

confidence: 99%

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The Role of Hormones and Toxoplasma gondii Infection to Change the Secondary Sex Ratio

Al-Ardi

2022

eijs

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The secondary sex ratio (SSR) is affected by many factors, including the concentration of hormones and infection with some pathogens such as Toxoplasma gondii. This study aimed to evaluate the effect of hormone variability concentrations and toxoplasmosis infection on the secondary sex ratio. 150 pregnant women were selected, 60 infected with late toxoplasmosis (LT), 60 infected with early toxoplasmosis (ET) and 30 seronegative to toxoplasmosis. After tracking the birth outcomes of these women, we calculated SSR in each group. During the second and third trimesters of pregnancy, estrogen, testosterone, progesterone, TSH, T4 and T3 concentrations were measured. The results of the three groups were compared. The results showed that female births outpaced in LT group, with SSR equal to (0.9:1.45), while the number of male births was higher in ET group and seronegative groups, with SSR was (1.5:1; 1.3:1), respectively. The difference in hormones concentration was significant at P ≥ 0.05. In LT group, progesterone and estrogen increased significantly in male pregnant women than in female pregnant women. Testosterone increased significantly in male pregnant women in all study groups. TSH level was the highest among female pregnant women in the LT and seronegative groups. The superiority of male pregnant women in the concentration of T3 hormone in all groups was significant. Male pregnant women were significantly superior with T4 concentration in LT and seronegative groups. In conclusion, T. gondii has an indirect role in SSR. Important pregnancy hormones levels differ between male pregnant women and female pregnant women. In conclusion, T. gondii has an indirect role in SSR. Important pregnancy hormones levels differ between male pregnant women o and female pregnant women.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The Role of Hormones and Toxoplasma gondii Infection to Change the Secondary Sex Ratio

Al-Ardi

2022

eijs

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“…P 4 has systemic immunomodulatory effect that is realized through the membrane [ 68 , 152 ] and classical nuclear receptors [ 87 , 153 , 154 , 155 , 156 ] in immune cells. Immune cells express both membrane and nuclear PRs [ 157 , 158 ], and their expression profile depends on the type of immune cells, microenvironment, and other factors, which should be clarified in further studies.…”

Section: Discussionmentioning

confidence: 99%

Progesterone as an Anti-Inflammatory Drug and Immunomodulator: New Aspects in Hormonal Regulation of the Inflammation

Федотчева

Shimanovsky

2022

Biomolecules

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The specific regulation of inflammatory processes by steroid hormones has been actively studied in recent years, especially by progesterone (P4) and progestins. The mechanisms of the anti-inflammatory and immunomodulatory P4 action are not fully clear. The anti-inflammatory effects of P4 can be defined as nonspecific, associated with the inhibition of NF-κB and COX, as well as the inhibition of prostaglandin synthesis, or as specific, associated with the regulation of T-cell activation, the regulation of the production of pro- and anti-inflammatory cytokines, and the phenomenon of immune tolerance. The specific anti-inflammatory effects of P4 and its derivatives (progestins) can also include the inhibition of proliferative signaling pathways and the antagonistic action against estrogen receptor beta-mediated signaling as a proinflammatory and mitogenic factor. The anti-inflammatory action of P4 is accomplished through the participation of progesterone receptor (PR) chaperones HSP90, as well as immunophilins FKBP51 and FKBP52, which are the validated targets of clinically approved immunosuppressive drugs. The immunomodulatory and anti-inflammatory effects of HSP90 inhibitors, tacrolimus and cyclosporine, are manifested, among other factors, due to their participation in the formation of an active ligand–receptor complex of P4 and their interaction with its constituent immunophilins. Pharmacological agents such as HSP90 inhibitors can restore the lost anti-inflammatory effect of glucocorticoids and P4 in chronic inflammatory and autoimmune diseases. By regulating the activity of FKBP51 and FKBP52, it is possible to increase or decrease hormonal signaling, as well as restore it during the development of hormone resistance. The combined action of immunophilin suppressors with steroid hormones may be a promising strategy in the treatment of chronic inflammatory and autoimmune diseases, including endometriosis, stress-related disorders, rheumatoid arthritis, and miscarriages. Presumably, the hormone receptor- and immunophilin-targeted drugs may act synergistically, allowing for a lower dose of each.

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“…Progesterone-induced blocking factor (PIBF), a protein produced by progesterone-stimulated lymphocytes, has immunomodulatory effects on CD4 + T cells probably through membrane progesterone receptors (mPRs) [ 52 ]. It has recently been found that vitamin D may upregulate PIBF in activated human peripheral lymphocytes and it is likely that vitamin D and progesterone exert their anti-inflammatory including IL-6-suppressing effects synergistically through PIBF [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of vitamin D supplementation on oxidative stress and inflammatory biomarkers in pregnant women: a systematic review and meta-analysis of clinical trials

Motamed¹,

Nikooyeh

Anari

et al. 2022

BMC Pregnancy Childbirth

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Background Vitamin D deficiency, a common problem among pregnant women, is linked with maternal inflammation, oxidative stress and consequent adverse pregnancy outcomes. The aim of this systematic review was to evaluate the effect of vitamin D supplementation on oxidative stress and inflammatory biomarkers in pregnant women according to the PRISMA guidance. Methods Four databases including PubMed/MEDLINE, Scopus, Web of Science and Cochrane were used for searching papers published until 25th July 2022. Clinical trials that assessed 25-Hydroxyvitamin D (25(OH)D), inflammatory markers (including high sensitivity C-reactive protein (hs-CRP) and certain cytokines) and oxidative stress markers (including malondialdehyde (MDA), total antioxidant capacity (TAC) and glutathione (GSH)) in pregnant women, were included in this review. The primary search of three databases displayed 21571 records. After removing duplicates and irrelevant articles, 17 eligible RCTs included for more evaluation. Random effect model and Der Simonian-Laird method were used to pool the data of studies. Risk of bias assessed according to version 2 of the Cochrane risk-of-bias tool for randomized trials. Results According to the meta-analysis result, vitamin D supplementation caused a significant increase in the maternal circulating concentrations of 25(OH)D (SMD 2.07; 95%, CI 1.51, 2.63; p < 0.001), TAC (SMD 2.13, 95% CI 1.04 to 3.23, p < 0.001) and GSH (SMD 4.37, 95% CI 2.9 to 5.74, p < 0.001) as well as a significant decrease in the levels of MDA (SMD -0.46, 95% CI -0.87 to -0.05, p = 0.02). However, it had no significant impact on hs-CRP concentrations (SMD 0.24; 95% CI, -0.55, 1.03; p = 0.50). Conclusion In the present study, vitamin D supplementation led to increased levels of 25(OH)D, TAC and GSH and also decreased concentration of MDA. Nevertheless, because of low certainty of evidence, these findings have to be declared conservatively. Trial registration Registration code in PROSPERO website: CRD42020202600

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Progesterone-induced blocking factor (PIBF) influences the expression of membrane progesterone receptors (mPRs) on peripheral CD4+ T lymphocyte cells in normal fertile females

Cited by 11 publications

References 37 publications

The Role of Hormones and Toxoplasma gondii Infection to Change the Secondary Sex Ratio

The Role of Hormones and Toxoplasma gondii Infection to Change the Secondary Sex Ratio

Progesterone as an Anti-Inflammatory Drug and Immunomodulator: New Aspects in Hormonal Regulation of the Inflammation

The effect of vitamin D supplementation on oxidative stress and inflammatory biomarkers in pregnant women: a systematic review and meta-analysis of clinical trials

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