Progesterone-induced porphyria

Levit, Edithe J.; Nodine, John H.; Perloff, William H.

doi:10.1016/0002-9343(57)90133-x

Cited by 43 publications

(5 citation statements)

References 21 publications

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“…Of particular interest is the frequency with which attack of acute porphyria could be precipitated with either endogenously produced or exogenously administered progesterone (Levit, Nodine & Perloff, 1957). The relation of human porphyria to known changes in sex steroids and adrenal steroids is similar to the relationship of Harderian gland porphyrins with these steroids reported in the present experiments.…”

Section: Resultssupporting

confidence: 71%

Influences of Some Endocrine Glands and of Hormone Replacement on the Porphyrins of the Harderian Glands of Mice

Shirama¹,

Furuya²,

Takeo³

et al. 1981

Journal of Endocrinology

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There are marked sex differences in the Harderian gland of the C3H/He strain of mice. Female (but not male) glands contain large amounts of porphyrin, which are readily visible as solid depositions within the lumina. The histology and porphyrin content of the Harderian gland were examined in intact and in pregnant mice and in mice subjected to combinations of adrenalectomy, gonadectomy and administration of sex steroid hormones. In male mice, castration approximately doubled the amount of porphyrin in the Harderian gland. Castration plus adrenalectomy increased the levels over 30-fold, to levels similar to those found in female mice, although adrenalectomy alone produced no significant effect. Administration of testosterone to the male mice which had been castrated and adrenalectomized prevented the increases while progesterone treatment produced further increases in porphyrins. In intact females, the amount of porphyrin varied with the phase of the oestrous cycle; being lowest during metoestrus and highest during dioestrus. In ovariectomized-adrenalectomized females, the effects of administered sex hormones on the amount of porphyrin in the gland were the same as in males. In pregnant mice, the level was no significantly different from that in intact oestrous animals.

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Section: Resultssupporting

confidence: 71%

Influences of Some Endocrine Glands and of Hormone Replacement on the Porphyrins of the Harderian Glands of Mice

Shirama¹,

Furuya²,

Takeo³

et al. 1981

Journal of Endocrinology

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“…Acute intermittent porphyria attacks are triggered by different environmental, metabolic and hormonal factors that cause increased activity of ALAS (4,6,7). Symptoms of acute intermittent porphyria are rarely seen before puberty (8), but women of child-bearing age are more frequently and more severely affected than men by acute intermittent porphyria, especially in the luteal phase of the menstrual cycle (4,7,(9)(10)(11)(12)(13)(14). Female sex steroids, especially progesterone, are regarded as important precipitating factors in menstrual cycle-related acute intermittent porphyria (4).…”

Section: Introductionmentioning

confidence: 99%

Women with acute intermittent porphyria have a defect in 5α‐steroid production during the menstrual cycle

Innala

Bäckström

Sundström‐Poromaa

et al. 2012

Acta Obstet Gynecol Scand

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“…Women most commonly have premenstrual attacks due to endogenous progesterone [2]. Studies indicate that progesterone, either endogenous or exogenous, induce attacks of acute porphyria [3]. Progesterone has also been implicated in increased haem catabolism [4].…”

Section: Discussionmentioning

confidence: 99%

An Interesting Case of Acute Intermittent Porphyria Precipitated During Premenstrual Phase

Mathavan¹,

Ameen²,

Durai³

2018

J Hematol Thrombo Dis

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Acute intermittent porphyria is one of the rare, autosomal dominant, hereditary hepatic porphyria due to deficiency of enzyme Hydroxyl Methyl Bilane synthase (HMB synthase) in the haem synthesis pathway. The condition is characterized by acute abdominal pain and neuropsychiatric manifestations. One of the precipitating causes of AIP is menstruation due to high levels of progesterone. We report an interesting case of AIP precipitated during each cycle of menstruation.

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Progesterone-induced porphyria

Cited by 43 publications

References 21 publications

Influences of Some Endocrine Glands and of Hormone Replacement on the Porphyrins of the Harderian Glands of Mice

Influences of Some Endocrine Glands and of Hormone Replacement on the Porphyrins of the Harderian Glands of Mice

Women with acute intermittent porphyria have a defect in 5α‐steroid production during the menstrual cycle

An Interesting Case of Acute Intermittent Porphyria Precipitated During Premenstrual Phase

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