Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators

Lancel, Marike; Faulhaber, Johannes; Holsboer, Florian; Rupprecht, Rainer

doi:10.1152/ajpendo.1996.271.4.e763

Cited by 104 publications

(100 citation statements)

References 19 publications

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“…Latency to non-REM sleep was arbitrarily defined as the 20th epoch of non-REM sleep and latency to REM sleep as the third epoch of REM sleep (Lancel et al, 1996). For each 2-h interval, total time spent in each vigilance state, average SWA within non-REM sleep, and average Tbr were computed.…”

Section: Assessment Of Sleep-wake Behavior and Brain Temperaturementioning

confidence: 99%

Clozapine Alters Sleep-Wake Behavior in Rats

Sorge

Pollmächer

Lancel

2004

Neuropsychopharmacol

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Clozapine is an atypical antipsychotic agent showing therapeutic efficacy superior to that of classical neuroleptics. Clozapine has strong sedative effects, but detailed studies on the drug influencing sleep in rodents are lacking. We studied the effects of clozapine on sleep and body temperature in rats. Clozapine (0, 2.5, and 7.5 mg/kg) was given i.p. to male Wistar rats at the beginning of the rest period. After administration of 7.5 mg/kg clozapine, animals were significantly more awake during the first 2 h postinjection. In parallel, the slow-wave activity (SWA) was suppressed. In the following 2 h non-REM sleep was markedly increased, whereas the SWA returned to baseline. At both doses clozapine decreased overall wakefulness and increased non-REM sleep on the first treatment day, which was associated with prolonged non-REM sleep episodes. These effects were transiently present even after subchronic treatment (7 days). After acute treatment, 7.5 mg/kg clozapine significantly reduced REM sleep and pre-REM sleep due to an increase in REM sleep latency and a reduction in the number of REM sleep episodes. Furthermore, clozapine produced a transient decrease in brain temperature that was followed by a moderate, but long-lasting elevation. To conclude, clozapine affected sleep-wake behavior in a way comparable to its effects in humans, suggesting that the rat is a suitable model for further studies on the underlying mechanisms.

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Section: Assessment Of Sleep-wake Behavior and Brain Temperaturementioning

confidence: 99%

Clozapine Alters Sleep-Wake Behavior in Rats

Sorge

Pollmächer

Lancel

2004

Neuropsychopharmacol

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“…33 These physiological processes are further affected by the remarkable fluctuations in immune and endocrine markers, especially inflammatory cytokines, progesterone, and estrogen, all of which have a substantial direct and indirect effect on sleep. [93][94][95][96][97][98][99][100] We assert that there is a need to identify pregnant women with insomnia, especially in early pregnancy, because insomnia could increase the risk of adverse outcomes to the mother and to the developing fetus. 33 The methods used to validate the ISQ (sleep diaries and/or actigraphy) are more commonly used than PSG when diagnosing insomnia, as well as when ascertaining sleep in pregnant women.…”

mentioning

confidence: 99%

Identifying Insomnia in Early Pregnancy: Validation of the Insomnia Symptoms Questionnaire (ISQ) in Pregnant Women

Okun

Buysse

Hall

2015

Journal of Clinical Sleep Medicine

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Study Objectives: Although a substantial number of pregnant women report symptoms of insomnia, few studies have used a validated instrument to determine the prevalence in early gestation. Identifi cation of insomnia in pregnancy is vital given the strong connection between insomnia and the incidence of depression, cardiovascular disease, or immune dysregulation. The goal of this paper is to provide additional psychometric evaluation and validation of the Insomnia Symptom Questionnaire (ISQ) and to establish prevalence rates of insomnia among a cohort of pregnant women during early gestation. Methods: The ISQ was evaluated in 143 pregnant women at 12 weeks gestation. The internal consistency and criterion validity of the dichotomized ISQ were compared to traditional measures of sleep from sleep diaries, actigraphy, and the Pittsburgh Sleep Quality Index using indices of sensitivity, specifi city, positive and negative predictive value (PPV, NPV), and likelihood ratio (LR) tests. Results: The ISQ identifi ed 12.6% of the sample as meeting a case defi nition of insomnia, consistent with established diagnostic criteria. Good reliability was established with Cronbach α = 0.86. The ISQ had high specifi city (most > 85%), but sensitivity, PPV, NPV, and LRs varied according to which sleep measure was used as the validating criterion. Conclusions: Insomnia is a health problem for many pregnant women at all stages in pregnancy. These data support the validity and reliability of the ISQ to identify insomnia in pregnant women. The ISQ is a short and cost-effective tool that can be quickly employed in large observational studies or in clinical practice where perinatal women are seen. 1 Among the many sleep complaints associated with pregnancy, diffi culty initiating or maintaining sleep or unrefreshing sleep, are the most frequently reported issues .1,2 Collectively these sleep symptoms comprise only one aspect of clinical insomnia. According to diagnostic criteria for insomnia, one must have: (1) a diffi culty initiating or maintaining sleep, and/or unrefreshing sleep despite adequate opportunity for sleep; (2) the duration of the sleep complaint is at least 1 mo; and (3) complaints of significant impairment in social, occupational, or daily functioning. 3,4 Insomnia is associated with activation of the stress system resulting in autonomic hyperarousa l. 5,6 It is also linked to various morbidities including depressi on.7-12 Emerging evidence implicates autonomic hyperarousal as a pathway through which the risk of depression is augmen ted. 13 This association is particularly relevant for pregnant women because there is evidence that depression is associated with an increased risk for preterm birth ( PTB), 14 and prenatal depression negatively impairs maternal-child bonding and neurocognitive develo pment.14-17 Having a simple diagnostic tool to identify clinical insomnia in pregnant women could be a fi rst step in reducing the incidence of depression, autonomic hyperarousal, as well as adverse pregnancy outcomes, such as PT...

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“…P4 easily crosses the BBB and activates inhibitory interneurons and limits excitatory activity [47][48][49][50][51][52][53] by gamma-aminobutyric acid (GABA)-mediated inhibition and by reducing the excitability of kainate receptors, [54][55][56][57] thereby attenuating and modulating neural responses. These effects could account for the short-term PFR reductions reported previously and response profile sharpening in sham and TBI brains that we report here.…”

Section: Short-term Effects Of P4 On Response Profiles In the Injuredmentioning

confidence: 99%

Progesterone sharpens temporal response profiles of sensory cortical neurons in animals exposed to traumatic brain injury.

et al. 2016

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Traumatic brain injury (TBI) initiates a cascade of pathophysiological changes that are both complex and difficult to treat. Progesterone (P4) is a neuroprotective treatment option that has shown excellent preclinical benefits in the treatment of TBI, but these benefits have not translated well in the clinic. We have previously shown that P4 exacerbates the already hypoactive upper cortical responses in the short-term post-TBI and does not reduce upper cortical hyperactivity in the long term, and we concluded that there is no tangible benefit to sensory cortex firing strength. Here we examined the effects of P4 treatment on temporal coding resolution in the rodent sensory cortex in both the short term (4 d) and long term (8 wk) following impactacceleration-induced TBI. We show that in the short-term postinjury, TBI has no effect on sensory cortex temporal resolution and that P4 also sharpens the response profile in all cortical layers in the uninjured brain and all layers other than layer 2 (L2) in the injured brain. In the long term, TBI broadens the response profile in all cortical layers despite firing rate hyperactivity being localized to upper cortical layers and P4 sharpens the response profile in TBI animals in all layers other than L2 and has no long-term effect in the sham brain. These results indicate that P4 has long-term effects on sensory coding that may translate to beneficial perceptual outcomes. The effects seen here, combined with previous beneficial preclinical data, emphasize that P4 is still a potential treatment option in ameliorating TBI-induced disorders.

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Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators

Cited by 104 publications

References 19 publications

Clozapine Alters Sleep-Wake Behavior in Rats

Clozapine Alters Sleep-Wake Behavior in Rats

Identifying Insomnia in Early Pregnancy: Validation of the Insomnia Symptoms Questionnaire (ISQ) in Pregnant Women

Progesterone sharpens temporal response profiles of sensory cortical neurons in animals exposed to traumatic brain injury.

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