Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system

Jameela, S.R.; Kumary, T. V.; Lal, Arthur Vijayan; Jayakrishnan, A.

doi:10.1016/s0168-3659(97)00187-9

Cited by 175 publications

(109 citation statements)

References 22 publications

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“…Based on the R2 values (table 4); chitosan SDs followed Higuchi model, it means that the release for these preparations was mainly in the diffusion process [41]. While the release mechanism of PVPbased SD preparations of different used ratios (SD7-SD9), (according to the R2 value) was apparently based on korsmeyer-peppas models, and as it was mentioned before, the "n" value determined exactly what the mechanism was, and as it was indicated here that at all ratios the mechanism was "super case II "based release which means that at the beginning of the release, PVP wasn't completely hydrated and so the free release would be hindered and the initial release was slow, then the drug would be released freely after the complete hydration/relaxation of PVP.…”

Section: Discussionmentioning

confidence: 99%

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Obaidat

Al-Taani

Al-quraan

2017

Int J Pharm Pharm Sci

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Objective: Meloxicam is classified as class II corresponding to its high permeability and low solubility (12μg/ml). This study aims to compare the effect of selected polymers on stabilization of amorphous form, and dissolution of meloxicam by preparation of different solid dispersions using selected polymers (chitosan oligomers, polyvinylpyrrolidone K30, and polyethylene glycols).Methods: These solid dispersions were prepared using two different methods; solvent evaporation method for the two molecular weights chitosan carriers (16 and 11KDa) and polyvinylpyrrolidone-K30 and melting method for the two different molecular weights polyethylene glycol (4000 and 6000). The physicochemical properties of solid dispersions were analyzed using differential scanning calorimetry, Fourier transform infra-red analysis, Powder X-ray diffraction, and scanning electron microscopy. Selected dispersions were then compared to two selected marketed drugs (Mobic® and Moven®).Results: Best dissolution rates were obtained for both polyvinylpyrrolidone-K30 and polyethylene glycol 6000, followed by chitosan 16 kDa, chitosan 11 kDa, and polyethylene glycol 4000. Increasing polymeric ratio increased dissolution rate except for chitosan. Precipitation of the drug as amorphous form occurred in chitosan and polyvinylpyrrolidone-K30 dispersions, while no change in crystallinity obtained for polyethylene glycol dispersions. Failure of polyvinylpyrrolidone-K30 in the maintenance of stability during storage time was observed while re-crystallization occurred in chitosan-based dispersions, which ends with preferences to polyethylene glycol dispersions. After comparing the release of selected dispersions with the two selected polymers; all dispersions got a higher release than that of the two marketed drugs release. Conclusion:The dissolution profile of meloxicam has been increased successfully in a reproducible manner.

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Section: Discussionmentioning

confidence: 99%

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Obaidat

Al-Taani

Al-quraan

2017

Int J Pharm Pharm Sci

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“…Biopolymer micro and nanoparticles have been proposed as an alternative to encapsulate progesterone (JAMEELA et al, 1998;LEMOS-SENNA et al, 1998;MATSUMOTO et al, 1999;LATHA et al, 2000;SILVA et al, 2006;SALEM, 2010). It is worth noting that besides the controlled delivery, encapsulation also provides protection from premature degradation during handling and storage before use, enhancement of absorption and bioavailability, improved retention time inside the organism and improvement of intracellular penetration (KUMARI et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

et al. 2015

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The encapsulation of progesterone in poly (hydroxybutirate-co-hydroxyvalerate) (PHBV), poly (ε-caprolactone) (PCL), poly (L-lactic acid) (PLLA) nanoparticles and PHBV/PCL and PHBV RESUMO A encapsulação de progesterona em nanopartículas de poli (hidroxibutirato-co-hidroxivalerato) (PHBV), poli (ε-caprolactona) (PCL), poli (L-ácido lático) (PLLA) e em nanopartículas blenda de PHBV/PCL e PHBV

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“…Not more than two of the individual weights deviate from the average weight by more than the percentage, and none deviate by more than twice the percentage. The mean and standard deviation were determined and reported [20].…”

Section: Uniformity Of Weightmentioning

confidence: 99%

“…This solution was suitably diluted with glacial acetic acid and assayed for temozolomide content by measuring the absorbance at 330 nm. Temozolomide contents were calculated, using the standard calibration curve [20].…”

Section: Procedures For Drug Content Uniformity Testmentioning

confidence: 99%

Formulation and Evaluation of Implantable Drug Delivery System of Temozolomide by Using Hydrophilic Polymer

Sindhu¹,

Bhavya²,

P³

et al. 2017

Asian J Pharm Clin Res

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Objective: The present research study was carried out to formulate and evaluate the implants of temozolomide using hydrophilic polymer.Methods: Temozolomide implants were formulated using extrusion method with different grades of carbopol. The powdered blend was evaluated for micromeritic properties such as angle of repose, bulk density, tapped density, Carr's index, and Hausner's ratio. The formulated implants were analyzed for drug content uniformity, thickness, weight variation, and short-term stability study. In vitro release study of implants was performed using 0.1N hydrochloric acid, and it is maintained at 37°C±0.5°C. Results:In vitro release study demonstrated that the release rate of temozolomide from the implant matrix was a function of concentration of the polymer. As the concentration of polymer was increased, drug release from the matrix was extended. The release of drug from all implant formulations was found to be uniform and was extended over a period of 12 hrs. The implant formulations were found sterile, uniform in weight and size. The drug content was found to be in the range of 97.2-101.33%. Conclusion:Drug interaction studies revealed that there were no chemical interactions between temozolomide and polymers used in the study. Short-term stability studies of implants revealed that implants were stable, and there were no significant changes in the physical appearance and drug content of the implant formulations. The results of the study demonstrated that implantable drug delivery system of temozolomide can be formulated using hydrophilic polymer.

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Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system

Cited by 175 publications

References 22 publications

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

Formulation and Evaluation of Implantable Drug Delivery System of Temozolomide by Using Hydrophilic Polymer

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