2008
DOI: 10.1159/000113758
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Progesterone Potentiates IP<sub>3</sub>-Mediated Calcium Signaling Through Akt/PKB

Abstract: The activity of cells critically depends on the control of their cytosolic free calcium ion (Ca2+) concentration. The objective of the present study was to identify mechanisms of action underlying the control of the gain of intracellular Ca2+ release by circulating gonadal steroid hormones. Acute stimulation of isolated neurons with progesterone led to IP3R-mediated Ca2+ transients that depend on the activation of the PI3 kinase/Akt/PKB signaling pathway. These resul… Show more

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Cited by 37 publications
(28 citation statements)
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“…This differential pattern of Ca 2+ signaling in ONHAs therefore potentially regulates gene expression (Hwang, et al, 2009, Koulen, et al, 2008) (Fig. 8) to adapt to changes in the astrocytic milieu and synaptic signaling, in accordance with the generally accepted view of astrocytes contributing critically to synaptic signaling and homeostasis (Dallerac, et al, 2013).…”
Section: Discussionsupporting
confidence: 77%
“…This differential pattern of Ca 2+ signaling in ONHAs therefore potentially regulates gene expression (Hwang, et al, 2009, Koulen, et al, 2008) (Fig. 8) to adapt to changes in the astrocytic milieu and synaptic signaling, in accordance with the generally accepted view of astrocytes contributing critically to synaptic signaling and homeostasis (Dallerac, et al, 2013).…”
Section: Discussionsupporting
confidence: 77%
“…It is thus reasonable to speculate that an enhanced activation of PI3K/Akt signaling resultant from redox-associated inactivation of PTEN is crucial to the pathophysiology of neurogenic hypertension via abnormal neuronal connections in RVLM of SHR. In addition, PI3K/Akt signaling may affect neuronal firing activity via the increase in open probability of calcium channels (26) and receptor trafficking of the excitatory ionotrophic glutamate receptors (11). Whether this redox-sensitive aberrant interplay between PI3K and PTEN on enhanced activation of PI3k/Akt signaling takes place in other brain nuclei involved in neural mechanism of hypertension, however, remains to be elucidated.…”
Section: Discussionmentioning
confidence: 99%
“…Downstream signalling of the PI3 kinase includes protein kinase PKB/Akt isoforms [29], which have been shown to be phosphorylated and thus presumably activated by LPS [28]. Akt/PKB regulates the transport across the cell membrane of diverse substances including glucose [30][31][32], amino acids [33][34][35], Ca 2+ [36], Na + [37], K + [38] and H + [39]. However, whether Akt1 activation is required for the effects of LPS on cell volume, ROS formation and Na + /H + exchanger activity, remained elusive.…”
Section: Introductionmentioning
confidence: 99%