Progesterone Receptor Expression Is an Independent Prognosticator in FIGO Stage I Uterine Leiomyosarcoma

Abstract

Hormone receptor expression is not informative of outcome in the analysis of uterine sarcomas of all stages and histologic types. PR expression identifies patients with longer survival in stage I leiomyosarcoma.

The mitosis‐specific marker phosphohistone‐H3 (PHH3) is an independent prognosticator in uterine smooth muscle tumours: an outcome‐based study

“…The mitotic index has been a significant prognostic parameter for LMS in some studies, but we found no significant association with outcome. This may be related to variables such as microscopic field diameters, counting methodology, cutoff points, and inaccuracy related to the presence of karyorrhectic nuclei.…”

“…Therefore, we believe that PHH3 has the potential to be a valuable additional prognosticator for stage I tumours. Similar observations have been made for the use of steroid hormone receptor expression in stage I LMS …”

“…57 Recently, a new nomogram system has been introduced for assessing the prognosis of LMS, but its power as a prognosticator remains to be validated. 67,68 The mitotic index has been a significant prognostic parameter for LMS in some studies, 48,49,52,55,56,[69][70][71] but we found no significant association with outcome. This may be related to variables such as microscopic field diameters, counting methodology, cutoff points, and inaccuracy related to the presence of karyorrhectic nuclei.…”

Efficacy of Hyperthermic Intraperitoneal Chemotherapy and Cytoreductive Surgery in the Treatment of Recurrent Uterine Sarcoma

“…9,28Y30 In LMS, higher mitotic rate and coagulative necrosis have been associated with lower survival, whereas higher ER or PR expression is associated with decreased risk of recurrence. 28,29 In our study, the highest mitotic rate (mean = 24/10 HPF) was observed in the conventional surgery group, but this group also had the highest expression of ER (64%) and PR (50%) when compared with the other groups. In ESS, mitotic rate has been considered the strongest prognostic factor.…”

Benign leiomyoma metastasizing to the lung: a case report and a brief review of the literature

“…Although the positivity of estrogen and progesterone receptors is considered to be an important feature for the diagnosis of uterine malignancy, [14] the mitotic activity was not evaluated on the lung specimen leading to the wrong diagnosis oh leiomyosarcoma initially. After pelvic surgery, due to the estrogen and progesterone positive receptors status of the lung nodules, we decided to use megestrol, according to previous experience.…”