Progesterone receptor in chicken bursa of Fabricius and thymus: evidence for expression in B-lymphocytes

Pasanen, Susanna; Ylikomi, Timo; Palojoki, Eeva; Syvälä, Heimo; Pelto‐Huikko, Markku; Tuohimaa, Pentti

doi:10.1016/s0303-7207(98)00086-0

Cited by 30 publications

(9 citation statements)

References 42 publications

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“…Estrogen and progesterone receptors are found on many immune cells including T-lymphocytes, B-lymphocytes, monocytes, and neutrophils. [14, 15] Potential effects on the immune system include the following: modulation of cellular activation levels (measured through CD38, CD25, CD69) which can impact both the number of lymphocytes infected with HIV and the rate of clearance of the infected cells[16]; disruption of the cytokine balance between TH1 and TH2 which diminishes the clearance of HIV infected cells[17]; and increased cellular senescence (measured through CD57, ki67, IDO). [18–20]…”

Section: Discussionmentioning

confidence: 99%

HIV disease progression by hormonal contraceptive method: secondary analysis of a randomized trial

Stringer

Levy²,

Sinkala³

et al. 2009

Aids

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Section: Discussionmentioning

confidence: 99%

HIV disease progression by hormonal contraceptive method: secondary analysis of a randomized trial

Stringer

Levy²,

Sinkala³

et al. 2009

Aids

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“…In mammals, the estrogen receptor (Koehler et al, 2005;Lamote et al, 2006) and androgen receptor (Sar et al, 1990;Benten et al, 2002) are present in various immune tissues. Reproductive steroid receptors are also present in lymphomyeloid tissues of birds (Sullivan et al, 1988;Pasanen et al, 1998) and fish (Slater and Schreck, 1993;Patino et al, 2000), as well as elasmobranch epigonal tissue (Squalus acanthias, Leucoraja erinacea; Engel, 2008).…”

Section: Discussionmentioning

confidence: 99%

Morphological relationships and leukocyte influence on steroid production in the epigonal organ‐ovary complex of the skate, Leucoraja erinacea

Lutton

Callard

2008

Journal of Morphology

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In elasmobranchs, a unique association exists between an immune tissue, the epigonal organ (EO), and the gonads. In this study, the histological and vascular relationships of the EO and ovarian follicles of the little skate, Leucoraja erinacea, were assessed. Perfusions of Evans blue dye and Batson's monomer showed a shared vascular pathway from the gonadal artery into the epigonal-ovary complex, with blood first entering the EO and then perfusing the ovarian follicles. Histological studies demonstrated direct cellular contact between epigonal leukocytes and the follicle wall (FW), as well as the presence of leukocytes between the steroidogenic theca and granulosa cells. In vitro analyses demonstrated that epigonal cells co-cultured with FW cells cause a dose-dependent inhibition of estrogen (E2) and testosterone (T) production. In contrast, conditioned media from epigonal leukocytes, stimulated or unstimulated with lipopolysaccharide (10 microg/ml), increase the production of E2 and T from FW cells of the ovaries. These studies provide a basis for further investigations of leukocyte secreted factors and cell contact modulation of follicular steroid production.

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“…The PR mRNA or the protein have been identified in human lymphocytes, human m ultiple myeloma cells, B cells, plasma cells and macrophages, as well as in murine hybridomas [38][39][40][41].…”

Section: Progesterone-mediated Immunomodulation In Pregnancy Reviewmentioning

confidence: 99%

Progesterone-Mediated Immunomodulation in Pregnancy: its Relevance to Leukocyte Immunotherapy of Recurrent Miscarriage

Szekeres-Barthó

2009

Immunotherapy

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Progesterone is crucial for the establishment and maintenance of pregnancy. Progesterone-regulated genes in the pregnant uterus control the development of endometrial receptivity as well as recruitment and differentiation of decidual NK cells, which in turn act on angiogenesis and trophoblast invasion. The link between progesterone and the immune system is established by lymphocyte progesterone receptors expressed in peripheral blood gammadelta T cells of pregnant women and in peripheral NK cells. Regulation of lymphocyte progesterone receptors is activation related, thus efficient recognition of fetal antigens is a requirement for the initiation of progesterone-dependent immunoregulatory mechanisms. Several immunological effects of progesterone are mediated by progesterone-induced blocking factor--the product of a progesterone-induced gene in lymphocytes. One part of unexplained recurrent miscarriages might have an immunological etiology. Immunization of the mothers with paternal or third-party leukocytes aims to correct the misregulated antifetal immune response. There are, however, serious concerns about this treatment, including the lack of information about the mode of action and possible adverse effects of the treatment, the failure to detect a significant effect of immunotherapy and the lack of a reliable generally accepted marker for patient selection. These concerns will be discussed in this review.

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Progesterone receptor in chicken bursa of Fabricius and thymus: evidence for expression in B-lymphocytes

Cited by 30 publications

References 42 publications

HIV disease progression by hormonal contraceptive method: secondary analysis of a randomized trial

HIV disease progression by hormonal contraceptive method: secondary analysis of a randomized trial

Morphological relationships and leukocyte influence on steroid production in the epigonal organ‐ovary complex of the skate, Leucoraja erinacea

Progesterone-Mediated Immunomodulation in Pregnancy: its Relevance to Leukocyte Immunotherapy of Recurrent Miscarriage

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