“…PGRMC1 localizes to endosomes, the endoplasmic reticulum (Nölte et al, 2000;Ahmed et al, 2010a), and the plasma membrane (Krebs et al, 2000), consistent with its highly conserved role in trafficking. In cancer, the best characterized trafficking target for PGRMC1 is the epidermal growth factor receptor (EGFR) tyrosine kinase (Ahmed et al, 2010a;Mir et al, 2012;Aizen and Thomas, 2015;Kabe et al, 2016), although PGRMC1 also increases plasma membrane pools of glucagon-like peptide-1 receptor and membrane progestin receptor a1, a plasma membrane progesterone receptor (Thomas et al, 2014;Zhang et al, 2014) that may be the target for PGRMC1-dependent progesterone signaling (Bashour and Wray, 2012;Peluso, 2013;Guo et al, 2016;Sun et al, 2016).…”