Progesterone, reproduction, and psychiatric illness

Standeven, Lindsay R.; McEvoy, Katherine; Osborne, Lauren M.

doi:10.1016/j.bpobgyn.2020.06.001

Cited by 30 publications

(23 citation statements)

References 170 publications

(149 reference statements)

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“…Progesterone is usually administered to treat premenstrual syndrome at 200-400 mg daily for 2 weeks by vaginal or oral administration (19). Furthermore, 200 mg progesterone is usually administered vaginally daily or 250 mg/week through intramuscular injection for weeks to prevent preterm birth (20). All patients in group A received a dose of 20 mg progesterone from 3 days before surgery to the operation day.…”

Section: The Use Of Progesteronementioning

confidence: 99%

Does Progesterone Affect Perioperative Blood Loss during Posterior Spinal Fusion Surgeries in Female Patients with Adolescent Idiopathic Scoliosis?: a retrospective study

Jiao

Tan

Wang

et al. 2022

Preprint

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Background: Menstruation is considered a contraindication for elective surgery for higher operative blood loss. Progesterone is often used to postpone menstruation to avoid surgery during menstruation. This study aimed to explore whether using progesterone to postpone menstruation affects perioperative blood loss in female patients with adolescent idiopathic scoliosis (AIS) who underwent posterior spinal fusion (PSF) surgery. Methods: A retrospective study was performed for female patients diagnosed with AIS who underwent PSF surgery between March 2013 and January 2021. Patients with irregular menstruation or before menarche,who used tranexamic acid, who underwent Schwab grade III–VI osteotomywere excluded. Patients scheduled to undergo PSF surgery from 2 days before menstruation to 3 days after menstruation were treated with progesterone preoperatively. The patients were divided into two groups according to progesterone use (group A, progesterone injection group; group B, control group). Demographic and surgical data including intraoperative blood loss (IBL), normalized blood loss (NBL), total blood loss (TBL), transfusion rate, perioperative complications, postoperative hospital stay,and preoperative coagulation function data. Results:Group A included 41 patients, while group B included 165. The two groups were matched for age, height, weight, operation time, Risser sign, correction rate, mean curve Cobb angle, bending Cobb angle, and number of internal fixations, number of fused levels (all P >0.05). Regarding coagulation function, no significant difference was found between thrombin time, activated partial thromboplastin time, fibrinogen, prothrombin time and platelet count. IBL, NBL and TBL were higher in group A; however, the difference was nonsignificant. Transfusion rate, perioperative complications, and postoperative hospital stay were not statistically different between groups. Conclusion: Intramuscular injection of progesterone to postpone menstruation did not affect perioperative blood loss in female AIS patients who underwent PSF surgery. Furthermore, it did not increase the incidence of perioperative complications or prolong postoperative hospital stay. Therefore, it may be a safe method for AIS patients to undergo PSF surgery as scheduled.

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Section: The Use Of Progesteronementioning

confidence: 99%

Does Progesterone Affect Perioperative Blood Loss during Posterior Spinal Fusion Surgeries in Female Patients with Adolescent Idiopathic Scoliosis?: a retrospective study

Jiao

Tan

Wang

et al. 2022

Preprint

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“…5 It is unclear if the variance in allopregnanolone levels influences mood or if it is an individual's reaction to the variation that affects mood. 7 Little is known about progesterone's other metabolites and/or synthetic progesterone. 6…”

Section: Estrogen and Progesterone's Impact On The Brainmentioning

confidence: 99%

Depressive symptoms in perimenopause

Mariño¹

2022

WHC

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“…During late pregnancy, a reduction in progesterone contributes to the progression of parturition and the initiation of lactation [ 2 ]. Progesterone influences the cellular metabolism [ 3 ] and mood symptoms [ 4 ]. Moreover, during pregnancy, estradiol is produced by the placenta, inducing various effects on the immune system and the brain [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Possible Stress–Neuroendocrine System–Psychological Symptoms Relationship in Pregnant Women during the COVID-19 Pandemic

Gizzi

Mazzeschi

Delvecchio

et al. 2022

IJERPH

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The COVID-19 pandemic induced long-term damages that weigh on the national health systems of various countries in terms of support and care. This review aimed to highlight the mental health impact of the COVID-19 pandemic in pregnant women. We first report data on the immune system physiopathology and the main viral infections in pregnancy, including COVID-19. Then, the attention is focused on the main factors that affect the mental health of pregnant women during the COVID-19 pandemic, such as (1) the fear of being infected and transmitting the infection to the fetus, (2) the cancellation of checkups and pre-child courses, and (3) confinement and the inability to have close friends or a partner at the time of delivery or in the first days after delivery, as well as family tensions. Because of all this, pregnant women find themselves in a stressful condition independent of the pregnancy, and thus experience anxiety, depression, insomnia, hostility, delirium, and an alteration of the mother–baby relationship. Several studies have shown an involvement of the hypothalamic–pituitary–adrenal axis and the hypothalamic–pituitary–thyroid axis in response to the pandemic. We propose a possible involvement of the neuroendocrine system as a mediator of the psychological symptoms of pregnant women induced by COVID-19-related stress.

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Progesterone, reproduction, and psychiatric illness

Cited by 30 publications

References 170 publications

Does Progesterone Affect Perioperative Blood Loss during Posterior Spinal Fusion Surgeries in Female Patients with Adolescent Idiopathic Scoliosis?: a retrospective study

Does Progesterone Affect Perioperative Blood Loss during Posterior Spinal Fusion Surgeries in Female Patients with Adolescent Idiopathic Scoliosis?: a retrospective study

Depressive symptoms in perimenopause

Possible Stress–Neuroendocrine System–Psychological Symptoms Relationship in Pregnant Women during the COVID-19 Pandemic

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