Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch

Abstract

Background: This is the first report about a vaginal leiomyoma concomitant with an ovarian luteoma in a bitch. Case presentation: A 11-year-old intact female Labrador retriever was referred because of anuria, constipation and protrusion of a vaginal mass through the vulvar commissure. The bitch had high serum progesterone concentration (4.94 ng/ml). Because of the possibility of progesterone responsiveness causing further increase of the vaginal mass and since the bitch was a poor surgical candidate a 10 mg/kg aglepristone treatment was started SC on referral day 1. A computerized tomography showed a 12.7 × 6.5 × 8.3 cm mass causing urethral and rectal compression, ureteral dilation and hydronephrosis. A vaginal leiomyoma was diagnosed on histology. As serum progesterone concentration kept increasing despite aglepristone treatment, a 0.02 ng/mL twice daily IM alfaprostol treatment was started on day 18. As neither treatment showed remission of clinical signs or luteolysis, ovariohysterectomy was performed on referral day 35. Multiple corpora lutea were found on both ovaries. On histology a luteoma was diagnosed on the left ovary. P4 levels were undetectable 7 days after surgery. Recovery was uneventful and 12 weeks after surgery tomography showed a reduction of 86.7% of the vaginal mass. The bitch has been in good health and able to urinate without any complication ever since. Conclusions: This case demonstrates the importance of identifying progesterone related conditions as well as the importance of judiciously using a combined medical and surgical approach.

Surgical Management of Multiple Vaginal Fibroma in a Golden Retriever

“…No specific breed predisposition was reported for the condition, however few reports recorded certain breeds are spitz, Labrador retriever and non-descript breed of dogs. 6,7 The clinical signs were in congruence with the reports presented earlier like hard mass protruded from vaginal canal by Balamurugan and Sivasudharsan. 6 The size, position and number of vaginal fibroma mass requiring episiotomy for complete surgical removal of the mass maybe the first choice.…”

Hyperprogesteronism associated with adrenocortical tumours in two dogs

“…Hyperprogesteronemia has previously been reported in a bitch with ovarian luteoma, 9 and in women with ovarian Sertoli cell tumour, 10 granulosa cell tumour 11 and Leydig cell tumour 12 . In Case 1, we did not investigate a potential ovarian origin to the excessive production of progesterone, as no ovarian abnormalities were found on imaging.…”

Determination of estrogen receptor, progesterone receptor and epidermal growth factor receptor in canine vaginal tumors and vaginal fold prolapse: A preliminary study

“…Vaginal fold prolapse occurs due to the elevated levels of estrogens during the proestrus and estrous stages of the sexual cycle (Sontas et al, 2010;Anila et al, 2020). The development and growth of the vaginal masses are considered to be stimulated by ovarian steroids and growth factors (Zhao et al, 2003;Ferré-Dolcet et al, 2020). The stage of the estrous cycle can be interpreted by vaginal cytology.…”

“…However, the use of steroidal hormones receptor antagonists was reported as an alternative treatment option because the growth of these masses may be stimulated by ovarian steroids (Rollón et al, 2008;Sathya and Linn, 2014). Ferré-Dolcet et al (2020) reported a case of progesteronesensitive vaginal leiomyoma in which they emphasized the importance of identifying progesterone-related conditions in order to decide on effective treatment as a combined medical and surgical approach.…”