Progesterone skin cream and measurements of absorption

CEU Managing Menopausal Symptoms After the Women's Health Initiative

“…In contrast, the human body is unable to metabolize wild yam cream, despite the similarities between the two compounds. 29 Although effective, progestin-only products have not been widely used due to concerns about safety. Use of these products may be associated with an increased risk of thromboembolic disease 30 and could theoretically increase the risk of breast cancer.…”

“…Although wild yam and progesterone creams share similar properties, progesterone is a derivative of cholesterol and, therefore, readily bioavailable. In contrast, the human body is unable to metabolize wild yam cream, despite the similarities between the two compounds 29 . Although effective, progestin‐only products have not been widely used due to concerns about safety.…”

The dangers of compounded bioidentical hormone replacement therapy

“…13 There is only very scant data available, but the current evidence has failed to show any endometrial protection from progesterone creams or gels. 16 There is also a concern with the bioidentical oral preparations, as there may be inconsistencies in the quantities of estradiol and other estrogen preparations in compounded preparations. This can lead to an increased risk of venous thromboembolism, as well as increasing the risk of endometrial cancer.…”