Progesterone transcriptionally regulates the beta 2-adrenergic receptor gene in pregnant rat myometrium.

Vivat, Valérie; Cohen‐Tannoudji, Joëlle; Revelli, Jean‐Pierre; Muzzin, Patrick; Giacobino, J P; Maltier, J. P.; Legrand, Chantal

doi:10.1016/s0021-9258(18)42394-0

Cited by 56 publications

(3 citation statements)

References 24 publications

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“…5 Progesterone and its related progestin have both an indirect and a direct, concentration-dependent relaxant effect on spontaneous myometrial contractile activity. [6][7][8] Progesterone is thought to modulate potassium channel activity. Potassium channels are widely expressed on the myocyte membrane surface 9 ; specifically, adenosine triphosphate-sensitive potassium channels (K ATP ), large conductance channel (BK Ca ), intermediate conductance channel (IK Ca ), voltage-operated channel (K V ), and small conductance channel (SK Ca ) are all present in pregnant myometrium.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Progesterone on Myometrial Contractility, Potassium Channels, and Tocolytic Efficacy

et al. 2009

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Section: Introductionmentioning

confidence: 99%

The Effect of Progesterone on Myometrial Contractility, Potassium Channels, and Tocolytic Efficacy

et al. 2009

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“…It is well documented the influence of sexual hormones on β2-ARs' expression in the myometrium. In specific, progesterone, through the control of the transcription rate of β2-AR gene in latepregnant rats, may increase the density of the receptors' expression [163,164]. In guinea pig, estradiol markedly upregulated the β2-AR density, while progesterone influenced β2-AR to a minor intensity [165].…”

Section: β3-ar In the Myometrium And Pregnancymentioning

confidence: 96%

Inside the Biology of the β3-Adrenoceptor

Pasha,

Tondo,

Favre

et al. 2024

Biomolecules

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Since the first discovery in 1989, the β3-adrenoceptor (β3-AR) has gained great attention because it showed the ability to regulate many physiologic and metabolic activities, such as thermogenesis and lipolysis in brown and white adipose tissue, respectively (BAT, WAT), negative inotropic effects in cardiomyocytes, and relaxation of the blood vessels and the urinary bladder. The β3-AR has been suggested as a potential target for cancer treatment, both in adult and pediatric tumors, since under hypoxia its upregulation in the tumor microenvironment (TME) regulates stromal cell differentiation, tumor growth and metastases, signifying that its agonism/antagonism could be useful for clinical benefits. Promising results in cancer research have proposed the β3-AR being targeted for the treatment of many conditions, with some drugs, at present, undergoing phase II and III clinical trials. In this review, we report the scientific journey followed by the research from the β3-Ars’ discovery, with focus on the β3-Ars’ role in cancer initiation and progression that elects it an intriguing target for novel antineoplastic approaches. The overview highlights the great potential of the β3-AR, both in physiologic and pathologic conditions, with the intention to display the possible benefits of β3-AR modulation in cancer reality.

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“…correlations between B -adrenergic receptors (B -AR) and gonadal steroid receptors have been found in human breast cancers, 10,11 rat cerebral cortex , 12 rodent myometrium ,13,14 hamster myocytes , 15 and bovine ovaries 16. Moreover , prolonged ẞ2 -AR stimulation upregulated uterine ER in immature rats¹7 and progesterone selectively upregulated B2 -AR in the myometrium of pregnant rats by increasing the rate of transcription of the B2-AR gene.¹18 gene.¹ 18 gene.¹ Cellular responses to many neurotransmitters wane quickly despite repeated exposure of target cells to the stimulus . This phenomenon , termed desensitization , has been particularly well studied regarding B-AR and has been attributed to various mechanisms , such as sequestration or internalization of B -AR , alteration in the functioning of B -AR that uncouples the Gprotein , or modifications in B -AR biosynthesis and/ or breakdown that affect the receptor concentrations 19.…”

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confidence: 99%

Down-regulation of β-adrenergic receptors and up-regulation of estrogen and progesterone receptors induced in the reproductive system of female veal calves by dietary clenbuterol

Re,

Badino,

Novelli

et al. 1995

ajvr

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SUMMARY Effects induced by long-term administration of clenbuterol at anabolic dosages (20 µg/kg of body weight for 40 days) on β-adrenergic receptor (β-ar) subtypes, estrogen receptors (er), and progesterone receptors (PgR) in the reproductive system of female veal calves were investigated. Clenbuterol treatment induced a significant (P < 0.01) down-regulation of β-ar subtypes (β1-ar, β2-ar, myometrial high-affinity β2-ar, and ovarian low-affinity β2-ar). On the other hand, a significant (P < 0.01) increase of uterine and ovarian er and PgR receptors was observed in treated calves. Treatment did not affect dissociation constant values of β-ar, er, or PgR. In similar manner, clenbuterol did not significantly modify distribution of er and PgR in the various tissues of the genital tract. In fact, these receptors were significantly (P < 0.05) more concentrated in the uterus than in the vagina in treated and untreated calves. Data indicated that prolonged clenbuterol exposure induced homologous β-ar down-regulation (down-regulation of its specific receptors) and heterologous er and PgR up-regulation (up-regulation of different types of receptors, not specifically bound by clenbuterol) in the genital tract of veal calves. Modification of the receptorial status could be reasonably related to the pathologic changes observed in long-term treated calves (eg, hydrometra, dilatation of uterine glands, cystic ovaries). The increased concentrations of er and PgR suggested the possible existence of subcellular mechanisms regulated by repeated β-adrenergic stimulation.

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Progesterone transcriptionally regulates the beta 2-adrenergic receptor gene in pregnant rat myometrium.

Cited by 56 publications

References 24 publications

The Effect of Progesterone on Myometrial Contractility, Potassium Channels, and Tocolytic Efficacy

The Effect of Progesterone on Myometrial Contractility, Potassium Channels, and Tocolytic Efficacy

Inside the Biology of the β3-Adrenoceptor

Down-regulation of β-adrenergic receptors and up-regulation of estrogen and progesterone receptors induced in the reproductive system of female veal calves by dietary clenbuterol

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